Intimate relation between genic expression of scavenger receptor CD36 and transcription factor SREBP2

Bernal-López, María Rosa; Llorente‐Cortés, Vicenta; Gómez-Huelgas, Ricardo; Badimon, Lina; Tinahones, Francisco J.

doi:10.1016/j.procbio.2010.03.009

Cited by 1 publication

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyperinsulinemia is related to an up-regulation of SREBPs [ 25 ], which could conflict with our results, but we previously showed that SREBP2 controls the expression of some LDL receptor genes, such as CD36 gene expression. A strong relation between SREBP2 and CD36 was found in FV but not in OPA [ 26 ]. Sampson et al [ 27 ] showed that diabetic subjects with good glycemic control had higher CD36 expression, which could reflect a post-transcriptional efficiency of this receptor and thus there would be greater metabolism of oxLDL in these patients.…”

Section: Discussionmentioning

confidence: 99%

Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes

Rosa

Llorente‐Cortés

Grech

et al. 2012

Cardiovasc Diabetol

View full text Add to dashboard Cite

The aims of this study were to check whether different biomarkers of inflammatory, apoptotic, immunological or lipid pathways had altered their expression in the occluded popliteal artery (OPA) compared with the internal mammary artery (IMA) and femoral vein (FV) and to examine whether glycemic control influenced the expression of these genes. The study included 20 patients with advanced atherosclerosis and type 2 diabetes mellitus, 15 of whom had peripheral arterial occlusive disease (PAOD), from whom samples of OPA and FV were collected. PAOD patients were classified based on their HbA1c as well (HbA1c ≤ 6.5) or poorly (HbA1c > 6.5) controlled patients. Controls for arteries without atherosclerosis comprised 5 IMA from patients with ischemic cardiomyopathy (ICM). mRNA, protein expression and histological studies were analyzed in IMA, OPA and FV. After analyzing 46 genes, OPA showed higher expression levels than IMA or FV for genes involved in thrombosis (F3), apoptosis (MMP2, MMP9, TIMP1 and TIM3), lipid metabolism (LRP1 and NDUFA), immune response (TLR2) and monocytes adhesion (CD83). Remarkably, MMP-9 expression was lower in OPA from well-controlled patients. In FV from diabetic patients with HbA1c ≤6.5, gene expression levels of BCL2, CDKN1A, COX2, NDUFA and SREBP2 were higher than in FV from those with HbA1c >6.5.The atherosclerotic process in OPA from diabetic patients was associated with high expression levels of inflammatory, lipid metabolism and apoptotic biomarkers. The degree of glycemic control was associated with gene expression markers of apoptosis, lipid metabolism and antioxidants in FV. However, the effect of glycemic control on pro-atherosclerotic gene expression was very low in arteries with established atherosclerosis.

show abstract

Section: Discussionmentioning

confidence: 99%