This study explored the roles of coping motives and frequency of heavy drinking episodes on the association between intolerance of uncertainty (IU) dimensions (i.e., prospective IU and inhibitory IU) and alcohol problems in a crowdsourced sample of adults (N = 375) of current drinkers. Serial mediation results indicated that there was a significant positive indirect effect of inhibitory IU on alcohol problems via coping motives and heavy drinking episodes. Unexpectedly, prospective IU had significant negative effects on frequency of heavy drinking episodes and alcohol problems. Implications of the study findings are discussed.