Intolerance to cosmetics as key to the diagnosis in a patient with allergic contact dermatitis caused by propylene glycol contained in a topical medication

Hernández, Noelia; Hernández, Z.; Liuti, Federica; Borrego, Leopoldo

doi:10.1111/cod.12689

Cited by 2 publications

(2 citation statements)

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“…Propylene glycol (PG) is a humectant and solvent commonly found in cosmetics, food 1,2 and medicaments, particularly in topical and gel preparations. 3 Over the years, there has been an increase in the number of personal care products (PCP) containing PG. 4 PG is a known cause of allergic contact dermatitis (ACD) and was deemed 'Allergen of the Year' by the American Contact Dermatitis Society in 2018.…”

Section: Introductionmentioning

confidence: 99%

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Allergic contact dermatitis from propylene glycol: A case series from Australia

2023

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Background Propylene glycol (PG) is used in a variety of cosmetics, food and pharmaceuticals. PG is a known sensitizer but also irritating when patch tested (PT). Objectives The aims were to investigate the frequency of contact sensitization to PG and to identify cases of allergic contact dermatitis (ACD). Methods A retrospective study was performed on patients PT at the Skin Health Institute (SHI), Victoria, Australia to PG 5% pet. and PG 10% aq. between 1 January 2005 and 31 December 2020. Results In all, 6761 patients were PT to PG and 21 (0.31%) reacted. Of those 21 individuals, 9 (42.9%) had a relevant reaction. 75% of relevant positive reactions were in patients PT to PG 10% aq. The most common source of PG exposure was topical medicaments (77.8% of relevant reactions) and moisturizers, with the largest group being topical corticosteroids. Conclusion Contact sensitization to PG in the patch test population remains uncommon, although it is possible that testing with concentrations of 5%–10% PG did not identify all reactions. Topical corticosteroids were the most important cause. Patients with suspected contact dermatitis to topical corticosteroids should be PT to PG.

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Section: Introductionmentioning

confidence: 99%

“…Propylene glycol (PG) is a humectant and solvent commonly found in cosmetics, food 1,2 and medicaments, particularly in topical and gel preparations 3 . Over the years, there has been an increase in the number of personal care products (PCP) containing PG 4 …”

Section: Introductionmentioning

confidence: 99%