Intoxicação espontânea por Baccharis coridifolia (Compositae) em ovinos

Rozza, Daniela Bernadete; Raymundo, Djeison Lutier; Corrêa, Ana Grasielle Dionísio; Leal, Juliano de Souza; Seitz, A.; Driemeier, David; Colodel, Edson Moleta

doi:10.1590/s0100-736x2006000100005

Cited by 18 publications

(32 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Spontaneous poisoning by B. coridifolia occurs frequently in cattle (Rissi et al 2005) occasionally in sheep (Rozza et al 2006) and rarely in horses (Alda et al 2009) Isolated reports of spontaneous outbreaks involving B. megapotamica var. weirii have been reported in cattle (Driemeier et al 2000) sheep (Pedroso et al 2010) and buffaloes (Oliveira-Filho et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

et al. 2012

View full text Add to dashboard Cite

Pesq. Vet. Bras. 32(5):383-390, maio 2012 383 RESUMO.-[Intoxicação experimental por Baccharis megapotamica var. weirii em búfalos.] As partes aéreas verdes de Baccharis megapotamica var. weirii foram administradas oralmente a cinco búfalos da raça Murrah de 6-8 meses de idade nas doses de 1, 3, 4, 5 e 10g/kg de peso corporal (pc) (~1-10mg de tricotecenos macrocíclicos/kg/ pc). A planta usada no experimento foi colhida numa fazenda onde um surto recente de intoxicação espontânea por essa planta havia ocorrido. Nos búfalos deste experimento, os sinais clínicos apareceram 4-20 horas e 4 búfalos morreram 18-49 horas após a ingestão da planta. Os sinais clíni-cos consistiram de apatia, anorexia, diarreia aquosa, febre, cólica, salivação, tremores musculares, inquietação, respiração laboriosa, atonia ruminal e desidratação. Five male 6-8 month-old Murrah buffalo calves were orally dosed with the fresh aerial parts of Baccharis megapotamica var. weirii at doses of 1, 3, 4, 5 and 10g/kg body weight (bw) (~1-10mg macrocyclic trichothecenes/kg/bw). The B. megapotamica used for the experiment was harvested on a farm where a recent spontaneous outbreak of poisoning caused by such plant had occurred. Clinical signs appeared 4-20 hours and 4 buffaloes died 18-49 hours after the ingestion of the plant. Clinical signs were apathy, anorexia, and watery diarrhea, fever, colic, drooling, muscle tremors, restlessness, laborious breathing and ruminal atony, and dehydration. The most consistent gross ϐindings were restricted to the gastrointestinal (GI) tract consisted of varying degrees of edema and reddening of the mucosa of the forestomach. Histopathological ϐindings consisted of varying degrees of necrosis of the epithelial lining of the forestomach and of lymphocytes within lymphoid organs and aggregates. Fibrin thrombi were consistently found in sub-mucosal vessels of the forestomach and in the lumen of hepatic sinusoids. It is suggested that dehydration, septicemia and disseminated intravascular coagulation participate in the pathogenesis of the intoxication and play a role as a cause of death. A subsample of B. megapotamica var. weirii was frozen-dried and ground and analyzed using UHPLC (Ultra High Performance Liquid Chromatography) with high resolution Time of Flight mass spectrometry and tandem mass spectrometry, it was shown that the plant material contained at least 51 different macrocyclic trichothecenes at a total level of 1.1-1.2mg/g. About 15-20% of the total trichothecenes contents was found to be monosaccharide conjugates, with two thirds of these being glucose conjugates and one third constituted by six aldopentose conjugates (probably xylose), which has never been reported in the literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In Brazil, three major toxic plants affecting livestock with pathologic alterations in the digestive tract are Baccharis coridifolia in sheep and bovines (Rozza et al 2006), B. megapotamica var. megapotamica and var.…”

Section: Discussionmentioning

confidence: 99%

Pathological aspects of experimental poisoning of goats by Stryphnodendron fissuratum pods (Fabaceae)

et al. 2013

Self Cite

View full text Add to dashboard Cite

Stryphnodendron fissuratum Mart. (Fabaceae) is an importantly toxic plant for livestock in Central-Western Brazil. Despite the recently published clinical descriptions of the poisoning, the gross and histopathological lesions of the disease needed to be better characterized. For this reason the pods of S. fissuratum were given orally to 10 young goats. The goats that received single doses of 10 g/kg, 20 g/kg and 40 g/kg and 4 fractioned doses of 5 g/kg, died poisoned. One goat that received a single dose of 10 g/kg recovered. Only those animals that received one dose of 5 g/kg did not become ill. At post mortem examination, the main lesions were associated with the digestive system and consisted of broken up epithelium and congestion of the mucosa of forestomachs and abomasum. Widespread areas of erosion and ulcerations were observed at the reticula and abomasal mucosa. Int these areas, the main lesions were neutrophil infiltration, vacuolization of the epithelial lining, swelling and dissociation of cells with cytoplasmic eosinophilia, pyknosis, karyorrhexis and nuclear karyolysis. In the central nervous system, the main lesions were identified in the brain of goats that received 20 g/kg and 40 g/kg of pods and consisted of spongiosis of the brainstem white matter. Based on these results, it was proved that the pods of S. fissuratum are acutely toxic for goats under the conditions of this experiment. The poisoning was characterized by damage to the organs of the digestive system and the central nervous system. Poisonous plants, rumen necrosis, spongiosis

show abstract

“…Outras plantas capazes de produzir quadros semelhantes tais como B. coridifolia (Tokarnia et al 2000), Eupatorium tremulum (Lucioli et al 2007) e Baccharidastrum triplinervium (Langohr et al 2005) não foram encontradas na propriedade em que ocorreram as mortes. Os achados clíni-cos e patológicos observados nesses cordeiros foram comparáveis aos descritos nas intoxicações naturais em bovinos e ovinos por B. coridifolia (Rissi et al 2005, Rozza et al 2006) e em bovinos por B. megapotamica var. weirii (Driemeier et al 2000), ou ainda nas intoxicações experimentais em ovinos por B. megapotamica var.…”

Section: Discussionunclassified

“…larmente como "mio-mio", é uma das mais importantes plantas tóxicas do Rio Grande do Sul (Tokarnia et al 2000, RietCorrea & Méndez 2007, mas também ocorre em Santa Catarina, Paraná e São Paulo (Barros 1998, Tokarnia et al 2000. Enquanto a intoxicação natural por B. coridifolia foi descrita em bovinos, ovinos e equinos (Rissi et al 2005, Rozza et al 2006, Alda et al 2009), a doença espontânea causada por Baccharis megapotamica foi registrada em bovinos importados do Uruguai (Driemeier et al 2000) para o Rio Grande do Sul. As duas variedades da planta, B. megapotamica var.…”

Section: Introductionunclassified

See 1 more Smart Citation

Intoxicação por Baccharis megapotamica var. weiriiem ovinos

et al. 2010

Self Cite

View full text Add to dashboard Cite

As intoxicações por Baccharis coridifolia afetam especialmente animais de fazenda famintos ou curiosos e que não haviam tido contato prévio com a planta. B. coridifolia ocorre usualmente em terrenos secos de coxilhas no Rio Grande do Sul e estados ou países vizinhos. Uma forma indistinguível e esporádica da doença tem sido associada com a ingestão de Baccharis megapotamica que ocorre em áreas úmidas. Relata-se a intoxicação natural de quatro cordeiros após ingestão de Baccharis megapotamica var. weirii. A doença foi observada em uma propriedade localizada em Barra do Ribeiro, Rio Grande do Sul. O rebanho era composto por 220 ovinos, os quais eram mantidos em área de pastagem nativa sem qualquer suplementação. Uma rápida doença clínica caracterizada por anorexia, cólica, diarréia e desidratação causou a morte de três cordeiros em um período de 8 a 24 horas, o outro foi encontrado morto. A necropsia revelou alterações significativas no rúmen, no qual havia edema de serosa e hemorragias equimóticas na submucosa. Microscopicamente, o rúmen apresentou edema de submucosa, além de edema, tumefação, vacuolização e necrose de mucosa. O diagnóstico foi fundamentado nos achados clínicos, patológicos e epidemiológicos.

show abstract

Intoxicação espontânea por Baccharis coridifolia (Compositae) em ovinos

Cited by 18 publications

References 2 publications

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

Pathological aspects of experimental poisoning of goats by Stryphnodendron fissuratum pods (Fabaceae)

Intoxicação por Baccharis megapotamica var. weiriiem ovinos

Contact Info

Product

Resources

About