Intoxication par la metformine : mécanismes de toxicité et prise en charge

Fourrier, F.; Seidowsky, Alexandre

doi:10.1016/j.reaurg.2010.05.011

Cited by 5 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, they need to be confirmed in further studies before they can be generalized to an unselected population of patients with less-specific suspected or known infection. Third, as it is impossible to determine the precise cause of hyperlactatemia in the context of infection, we did not account for the potential for treatment-related hyperlactatemia in the analyses of our results, such as metformin overdose [ 75 ] or β 2 mimetic administration [ 76 ]. Finally, lactatemia measurements were performed with ICU devices as part of local management protocols [ 77 ], primarily to avoid mismeasurement due to the time of transport to the laboratory: our results therefore require confirmation with laboratory-based analytical devices for lactatemia measurements but are nevertheless representative of a real-world clinical situation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Goutay

Perche

Toussaint

et al. 2021

Critical Care Research and Practice

View full text Add to dashboard Cite

Objective. Our primary aim was to assess selected metabolic dysfunction parameters, both independently and as a complement to the SOFA score, as predictors of short-term mortality in patients with infection admitted to the intensive care unit (ICU). Methods. We retrospectively enrolled all consecutive adult patients admitted to the eight ICUs of Lille University Hospital, between January 2015 and September 2016, with suspected or confirmed infection. We selected seven routinely measured biological and clinical parameters of metabolic dysfunction (maximal arterial lactatemia, minimal and maximal temperature, minimal and maximal glycaemia, cholesterolemia, and triglyceridemia), in addition to age and the Charlson’s comorbidity score. All parameters and SOFA scores were recorded within 24 h of admission. Results. We included 956 patients with infection, among which 295 (30.9%) died within 90 days. Among the seven metabolic parameters investigated, only maximal lactatemia was associated with higher risk of 90-day hospital mortality in SOFA-adjusted analyses (SOFA-adjusted OR, 1.17; 95%CI, 1.10 to 1.25; p < 0.001 ). Age and the Charlson’s comorbidity score were also statistically associated with a poor prognosis in SOFA-adjusted analyses. We were thus able to develop a metabolic failure, age, and comorbidity assessment (MACA) score based on scales of lactatemia, age, and the Charlson’s score, intended for use in combination with the SOFA score. Conclusions. The maximal lactatemia level within 24 h of ICU admission is the best predictor of short-term mortality among seven measures of metabolic dysfunction. Our combined “SOFA + MACA” score could facilitate early detection of patients likely to develop severe infections. Its accuracy requires further evaluation.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Goutay

Perche

Toussaint

et al. 2021

Critical Care Research and Practice

View full text Add to dashboard Cite

show abstract

“…In the absence of overdose or intoxication, the side effects of metformin are usually minor, consisting of digestive disorders: dyspepsia, nausea, vomiting. Exceptional cases of pancreatitis and rhabdomyolysis have been reported [3]. Lactic acidosis still the most important and dangerous side effect of acute and chronic metformin use, its mortality can reach up 50% [4,5].…”

Section: Introductionmentioning

confidence: 99%

Fatal Metformin Poisoning: Adolescent Case Report

Halhoul,

Bousseaden,

Assioui

et al. 2023

austinpediatr

View full text Add to dashboard Cite

Metformin is a biguanide oral hypoglycemic agent used for non-insulin dependent diabetes mellitus. Lactic acidosis still the most important and dangerous side effect of acute and chronic metformin use, its mortality can reach up 50%. Metformin poisoning in children remains rare and is very rarely reported in the literature. The curative treatment is based on early extrarenal purification by haemodialysis or haemodiafiltration. However, the prognosis of high doses of metformin can be fatal. We are reporting the case of a 14-year-old female patient who intentionally overdosed on metformin, resulting in lactic acidosis and death.

show abstract

Produit de contraste iodé et metformine

Legeay¹,

Faure²

2023

Actualités Pharmaceutiques

View full text Add to dashboard Cite

Intoxication par la metformine : mécanismes de toxicité et prise en charge

Cited by 5 publications

References 28 publications

Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Fatal Metformin Poisoning: Adolescent Case Report

Produit de contraste iodé et metformine

Contact Info

Product

Resources

About