Intoxications aiguës par des produits phytosanitaires chez l’enfant

Leveau, Philippe

doi:10.1016/j.arcped.2016.04.021

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Some clinical patterns (toxidromes) are suggestive of the drug class: cholinergic crisis for organophosphate or carbamate insecticides; neurological syndrome for rodenticides; digestive and respiratory syndrome for herbicides. Treatment is symptomatic and only a few patients are treated with an antidote: atropine and pralidoxime for organophosphate insecticides, or vitamin K for anticoagulant rodenticides [ 10 ]. The long-term consequences of pesticide poisoning may include organ damage, long-term disability, or even death.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Emergency Department Management in Acute Poisoning—A 2-Year Retrospective Study

Corlade-Andrei

Nedelea

Ionescu

et al. 2023

JPM

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(1) Background: Poisonings in children are common reasons for addressing ED and can potentially have serious complications. Our research aims to review risk factors leading to poisoning in children. (2) Methods: A retrospective review of all pediatric poisoning cases addressing the Children’s emergency department of St Mary Hospital over a two-year period was performed. (3) Results: We collected data on 797 children admitted for acute poisoning. The highest incidence identified was in the 12–18 and 1–3-year-old age groups. The distribution of voluntary versus unintentional poisonings was relatively balanced: 50.19% versus 47.43% (for some cases the type of intoxication remained unknown). Exposure to the toxic substance by ingestion was significant compared to the other routes, with an incidence of 87.1%. Acute poisoning happened at home in 70.4% of cases. A known risk factor before reaching the ED was present in 13.04%. (4) Conclusions: Our study showed a greater risk for acute poisoning in children between 1–3 years of age, and adolescents over 12 years. Identifying and documenting epidemiological aspects and other variables is important for establishing preventive measures and for therapeutic conduct. Adequate risk stratification and preventive measures involving closer supervision of minors or cognitive-behavioral programs can prevent voluntary intoxication.

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Section: Discussionmentioning

confidence: 99%

Pediatric Emergency Department Management in Acute Poisoning—A 2-Year Retrospective Study

Corlade-Andrei

Nedelea

Ionescu

et al. 2023

JPM

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“…This is the major differential diagnosis for OP poisoning, which is clinically indistinguishable from carbamate toxicity, and the treatment approach is essentially the same as observed for OP poisoning. Oxime is not indicated due to the spontaneous hydrolysis of the carbamate-cholinesterase binding, but pralidoxime is recommended when atropine treatment is poorly effective or ineffective [9].…”

Section: Discussionmentioning

confidence: 99%

Acute Pesticide Poisoning in Children: A Review of 50 Cases

Khalsi

Trablesi

Belhadj

et al. 2018

IJT

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Background: Pesticide poisoning is very common in Tunisia. Various factors are involved in the analysis of the clinical presentations and the severity of this condition. Major factors are the chemical nature of the pesticides and the quantity entered the body. Methods: This is a retrospective study, reporting the pediatric cases that presented to us with signs and symptoms of pesticide poisoning. Fifty cases pesticide poisoning were admitted to the hospital between January 2013 and October 2016. Results: A total of 50 pediatric cases were included in this study with the mean age of 3 years and 4months. The poisoning was accidental in 49 cases and self-inflicted in one, with the mode being oral (N=45), respiratory (N=2) and cutaneous (N=3). The average duration of hospital care for these patients was 2 hours and 30 minutes (range: 30 min-24 hr). The clinical manifestations of poisoning noted were due to muscarinic and nicotinic receptors inhibition. Upon clinical examination, 29 patients had no pesticide in the gastric lavage fluid and urine and demonstrated no abnormal cholinesterase activity. The therapeutic management was mainly symptomatic with antidote medications prescribed (atropine and oxime). All patients had favorable outcomes and no death occurred. Conclusion: This study demonstrated the frequency of pesticide poisoning in a pediatric setting and the importance of early management. Optimal therapeutic approaches were evaluated, demonstrating that prevention still remains the best solution in such cases.

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“…Magnesium sulfate can be used for managing the poisoning with organophosphorus pesticides 64 and aluminum phosphide 65 . Pralidoxime and vitamin K are antidotes of organophosphorus insecticides and anticoagulant rodenticides, respectively 66 . 1,8-Naphthalic anhydride is a potential antidote against fungicides 67 .…”

Section: Introductionmentioning

confidence: 99%

Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria

Syromyatnikov

Nesterova

Smirnova

et al. 2021

Sci Rep

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The population of bumble bees and other pollinators has considerably declined worldwide, probably, due to the toxic effect of pesticides used in agriculture. Inexpensive and available antidotes can be one of the solutions for the problem of pesticide toxicity for pollinators. We studied the properties of the thiazine dye Methylene blue (MB) as an antidote against the toxic action of pesticides in the bumble bee mitochondria and found that MB stimulated mitochondrial respiration mediated by Complex I of the electron transport chain (ETC) and increased respiration of the mitochondria treated with mitochondria-targeted (chlorfenapyr, hydramethylnon, pyridaben, tolfenpyrad, and fenazaquin) and non-mitochondrial (deltamethrin, metribuzin, and penconazole) pesticides. MB also restored the mitochondrial membrane potential dissipated by the pesticides affecting the ETC. The mechanism of MB action is most probably related to its ability to shunt electron flow in the mitochondrial ETC.

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Intoxications aiguës par des produits phytosanitaires chez l’enfant

Cited by 5 publications

References 25 publications

Pediatric Emergency Department Management in Acute Poisoning—A 2-Year Retrospective Study

Pediatric Emergency Department Management in Acute Poisoning—A 2-Year Retrospective Study

Acute Pesticide Poisoning in Children: A Review of 50 Cases

Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria

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