Intra-abdominal Candida infection during acute necrotizing pancreatitis has a high prevalence and is associated with increased mortality

Abstract

Given the impact of Candida infection on mortality to acute necrotizing pancreatitis and the apparent benefit from antimycotic chemotherapy, the data argue for an early fungicide chemotherapeutic intervention.

Prevention and therapy of fungal infection in severe acute pancreatitis: A prospective clinical study

“…Before routine administration of prophylactic antibiotics for SAP, the proportion of fungi was 7 % in the bacteria spectrum of SAP infection [9] . After that, the incidence of fungal infection in SAP has increased to 12-41 % [2,3,5,6,8,[10][11][12][13][14] , which has become an important cause for death and mutilation by SAP [3,5,6,8,[10][11][12][13][14] . Since lack of specific manifestations, unrecongizability of symptoms, a long time for fungal cultivation, and apparent relevance between the fungal infection and prognosis, active and effective measures to prevent SAP deep fungal infection will contribute to further decreasing the mortality of SAP.…”

Practice Guidelines in Acute Pancreatitis

“…This risk appears to correlate with prolonged use of antibiotic therapy (62)(63)(64). While the prevalence of fungal infection among patients with necrotizing pancreatitis in recent studies has been 9% (range 8-35%) (62,64,65,91,110,119,187), it remains unclear whether mortality is significantly higher when there is superimposed fungal infection. Some reports indicate a greater mortality (63,65,91,116), whereas others do not (62,64,115,119,187).…”

The Intricate Nature of SERS: Real‐Life Applications and Challenges

“…In the last decades, SERS was used to identify: DNA bases [58], a wide range of explosives and trace materials [59], food additives [60], therapeutic agents [61], different species of pathogenic and nonpathogenic bacteria [62][63][64], protozoa [65], fungi [66,67], and their spores [68], respectively. Furthermore, as previously described, vibrational spectroscopy can be used to study the uniqueness of microorganisms.…”

“…For example, various pathogens such as Candida albicans, C. glabrata, and C. tropicalis isolated from blood cultures have been rapidly identified [66]. Rapid diagnosis of infections caused by fungi from Candida genus is extremely important, since intra-abdominal infections caused by these fungi lead to high mortality rates [67]. Yang and Irudayaraj [69] were able to easily identify A. niger and F. verticillioides pathogenic fungi from apple surface, using FT-Raman spectroscopy.…”