Technical failure (TF) continues to have a significant impact on the success of pancreas transplantation. We assessed risk factors for TF in 1,115 pancreas transplants performed at a single center between 1998–2011. The relationships of donor and recipient factors, surgical approach, allo-sensitization and matching, and immunosuppressive agents were correlated with risk of TF. In a multivariable model, donor BMI ≥30, donor Cr ≥2.5, donor age >50, and preservation time >20 hours were associated with TF. Bladder drainage of exocrine secretions was protective. We incorporated these factors in a Composite Risk Model and tested its ability to predict TF in comparison to existing models (pDRI). In the Composite Risk Model, the presence of one risk factor did not significantly increase risk of TF, but two or more risk factors in combination were predictive. The analysis also identifies many factors that were not predictive of TF, including previous transplants, immunosuppressive agent selection, and almost all recipient demographic parameters. While the model suggests that two or more risk factors predict TF, strategies to reduce preservation time may mitigate some of this risk.