Intra-abdominal vagal blocking (VBLOC therapy): Clinical results with a new implantable medical device

Camilleri, Michael; Toouli, James; Herrera, Miguel F.; Kulseng, Bård; Kow, Lilian; Pantoja, Juan Pablo; Mårvik, Ronald; Johnsen, Gjermund; Billington, Charles J.; Moody, Frank G.; Knudson, Mark B.; Tweden, Katherine S.; Vollmer, Mark C.; Wilson, Richard; Anvari, Mehran

doi:10.1016/j.surg.2008.03.015

Cited by 142 publications

(123 citation statements)

References 14 publications

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“…A high-frequency alternating electric current impulse generated by an implanted generator blocks the branches of vagal nerve. The electrodes are placed near the vagal nerves in the gastroesophageal junction (24).…”

Section: Discussionmentioning

confidence: 99%

Gastric stimulation in treatment in type 2 diabetes mellitus

Zonča¹,

Hoppe²,

Cambal³

et al. 2014

BLL

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Metabolic surgery is a dynamic fi eld providing a wide range of new techniques. The aim of our paper is to inform about gastric electrostimulation in the treatment of type 2 diabetes mellitus. Gastric electrostimulation in type 2 diabetes mellitus treatment is performed by means of implanting Tantalus system (Metacure). When triggered by food intake, the Tantalus system generates signals for the stomach to contract. Early after the food intake, thus before the stomach distends completely, the system increases spontaneous stomach contractions. Via afferent vagal signals, these increased contractions are evaluated by the central nervous system as a sign that satiety has been reached. Three pairs of electrodes connected with a stimulator are implanted laparoscopically. The system comes equipped with a battery as well. Laparoscopically implanted system of stomach electrostimulation presents a simple and easily regulated system without disturbing the integrity of gastrointestinal tract. It is a reversible system. In accord with preliminary results, Tantalus offers a safe and effective treatment of type 2 diabetes mellitus by reducing other cardiometabolical risky factors. The operation safety is comparable with that of similar minimally invasive surgical techniques. In order to improve our understanding of diabetes mellitus pathophysiology as well as of effects of gastric electrostimulation, more trials need to be performed. The surgical diabetes treatment represents an interesting chance for patients and it might become a common technique in the future (Fig. 1, Ref. 29). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Gastric stimulation in treatment in type 2 diabetes mellitus

Zonča¹,

Hoppe²,

Cambal³

et al. 2014

BLL

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“…A recent study in humans examining a device that intermittently blocks vagal nerve activity at the gastrooesophageal junction (VBLOC) [27] found that the device appeared to lower PP response to sham feeding. Furthermore, greater weight loss occurred in individuals with a PP meal response <25 pg/ml compared to a response >25 pg/ ml.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Polypeptide Meal Response May Predict Gastric Band-Induced Weight Loss

et al. 2011

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“…Studies in animal models showed that intermittent highfrequency electrical stimulation of the vagus can induce reversible inhibition of flow of signals via the nerve [38]. Initial human studies showed that the technique can induce a significant weight loss in obese subjects [39] and the electrical stimulation was then further refined [40], leading to a prospective, multicenter, randomized double-blind, controlled trial (sponsored by EnteroMedics). The treatment group received biphasic pulses, at a frequency of 5000 Hz and amplitude of 3-8 mA, alternating between 5 min on and 5 min off, delivered for at least 9 h a day.…”

Section: Vblock Therapy Systemmentioning

confidence: 99%

Gastric Electrical Stimulation for Obesity

Chiu

Soffer

2015

Curr Gastroenterol Rep

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Obesity is a growing health problem worldwide with a major impact on health and healthcare expenditures. Medical therapy in the form of diet and pharmacotherapy has limited effect on weight. Standard bariatric surgery is effective but is associated with morbidity and mortality, creating an unmet need for alternative therapies. One such therapy, the application of electrical stimulation to the stomach, has been studied extensively for the last two decades. Though pulse parameters differ between the various techniques used, the rationale behind this assumes that application of electrical current can interfere with gastric motor function or modulate afferent signaling to the brain or both. Initial studies led by industry failed to show an effect on body weight. However, more recently, there has been a renewed interest in this therapeutic modality with a number of concepts being evaluated in large human trials. If successful, this minimally invasive and low-risk intervention would be an important addition to the existing menu of therapies for obesity.

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Intra-abdominal vagal blocking (VBLOC therapy): Clinical results with a new implantable medical device

Cited by 142 publications

References 14 publications

Gastric stimulation in treatment in type 2 diabetes mellitus

Gastric stimulation in treatment in type 2 diabetes mellitus

Pancreatic Polypeptide Meal Response May Predict Gastric Band-Induced Weight Loss

Gastric Electrical Stimulation for Obesity

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