Intra‐adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases

Ide, Hisamitsu; Lu, Yuming; Ono, Masaya; Tokairin, Takuo; Okada, Hiroshi; Horie, Shigeo

doi:10.1111/iju.13515

Cited by 2 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two main types of ACTH‐positive steroidogenic cells have been described in humans with PBMAH: large cells filled with lipid droplets called clear cells or spongiocytic cells, and small dense eosinophilic cells called compact cells. 9 , 10 , 11 , 12 In our dog, 1 cell type was similar to human compact cells with positive staining for ACTH and a second type, similar to human spongiocytic cells positive for ACTH and negative for 3βHSD. Although colabelling with ACTH and 3βHSD antibodies was not confirmed in compact cells, it appears that the areas of the adrenal tissues positive for ACTH also expressed 3βHSD but not synaptophysin, indicating that they likely correspond to adrenocortical tissue.…”

Section: Discussionsupporting

confidence: 67%

“…Immunostaining for ACTH was present in the adrenal cortex in our case as it occurs in humans with PBMAH. 9 , 10 , 11 , 12 Although both adrenal cortices had a macroscopic micronodular appearance, the histological evaluation was compatible with diffuse hyperplasia. This apparent discrepancy between the micronodular macroscopic appearance of the adrenal glands and the pattern of diffuse hyperplasia observed histologically could be explained by a lack of atrophy of the internodular adrenocortical tissue.…”

Section: Discussionmentioning

confidence: 90%

“…Previous case reports confirmed the expression, secretion and paracrine action of ACTH on PBMAH in humans with clinical or subclinical CS. 9 , 10 , 11 , 12 Surprisingly, these patients have low or suppressed ACTH concentrations, suggesting that not all forms of ACTH‐dependent adrenal hyperplasia have increased circulating ACTH concentrations. 11 This report describes the first case of CS in a dog caused by primary bilateral nodular adrenocortical hyperplasia associated with abnormal expression of intra‐adrenocortical ACTH.…”

Section: Discussionmentioning

confidence: 97%

“… 9 , 10 At present, few cases of CS caused by intra‐adrenal ACTH production by steroidogenic cells in PBMAH have been reported in humans. 9 , 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cushing's syndrome caused by intra‐adrenocortical adrenocorticotropic hormone in a dog

Arias

Castillo

Louiset

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

A 13‐year‐old Labrador retriever was diagnosed with Cushing's syndrome (CS) caused by primary bilateral nodular adrenocortical hyperplasia with adrenocorticotropic hormone (ACTH) expression. The pituitary origin of CS was ruled out by suppression of plasma ACTH concentration and absence of a proliferative lesion on histological evaluation of the pituitary gland using periodic acid‐Schiff (PAS) staining, reticulin staining, and immunostaining for ACTH. A pheochromocytoma also was found at necropsy examination. On histological evaluation of both adrenal glands, at the junction of the fascicular and glomerular zones, multiple cell clusters distributed in both hyperplastic adrenal cortices expressed ACTH, whereas the pheochromocytoma cells did not. These results indicate that a disease similar to primary bilateral macronodular adrenocortical hyperplasia in humans also occurs in dogs, with intra‐adrenocortical expression of ACTH, glucocorticoids excess, and clinical signs of CS. Therefore, the term ACTH‐independent could be inappropriate in some cases of bilateral adrenocortical hyperplasia and suppressed plasma ACTH concentration in dogs.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

“… 9 , 10 At present, few cases of CS caused by intra‐adrenal ACTH production by steroidogenic cells in PBMAH have been reported in humans. 9 , 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cushing's syndrome caused by intra‐adrenocortical adrenocorticotropic hormone in a dog

Arias

Castillo

Louiset

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

Adrenal Hemangioma: A Case of Retroperitoneal Tumor

Iwamoto

Shimokihara

Kawahara

et al. 2018

Case Reports in Medicine

View full text Add to dashboard Cite

Introduction Adrenal hemangioma is a rare disease, with only some 60 cases reported previously. Due to the difficulty of the preoperative diagnosis of adrenal hemangioma, almost all of the cases were diagnosed by a histopathological analysis of surgical specimens. Case Presentation A 52-year-old man was referred to our department for further examination of his left retroperitoneal tumor. He had received hemodialysis due to chronic renal failure resulting from membranous nephropathy. Computed tomography revealed a mass around his left hilum. Magnetic resonance imaging (MRI) and positron-emission tomography (PET)-CT were unable to confirm or deny malignancy, and tumor markers, including CEA and CA19-9, showed slight elevation. His tumor grew from 38 mm to 54 mm in diameter in 7 months of follow-up. We therefore planned retroperitoneal tumor resection with left nephrectomy. Histopathologically, hyperplastic small vessels with hemorrhaging and denaturation were seen. The endothelial cells showed no variants or division of the nucleus. Based on this diagnosis, no further therapy was performed. He has had no recurrence in the eight months since the surgery. Conclusion We herein report a rare case of adrenal hemangioma.

show abstract

Intra‐adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases

Cited by 2 publications

References 3 publications

Cushing's syndrome caused by intra‐adrenocortical adrenocorticotropic hormone in a dog

Cushing's syndrome caused by intra‐adrenocortical adrenocorticotropic hormone in a dog

Adrenal Hemangioma: A Case of Retroperitoneal Tumor

Contact Info

Product

Resources

About