Intra- and Inter-Scanner Reliability of Voxel-Wise Whole-Brain Analytic Metrics for Resting State fMRI

Zhao, Na; Yuan, Lijun; Jia, Xize; Zhou, Xinchun; Deng, Xin‐Ping; He, Hongjian; Zhong, Jianhui; Wang, Jue; Zang, Yu‐Feng

doi:10.3389/fninf.2018.00054

Cited by 77 publications

(84 citation statements)

References 34 publications

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“…Significantly lower fluctuation in EO than in EC was found in the bilateral PSMC, SMA, paracentral lobule, thalamus, and primary auditory cortex (P < 0.05, corrected). All these results were highly consistent with previous studies [17,[22][23][24][25][26]. For mfALFF ( Fig 2E) and zfALFF ( Fig 2F), the pattern of difference between EO and EC was generally similar with that of mPerAF, zPerAF, mALFF, and zALFF, except for that in the frontal pole and PSMC.…”

Section: Paired T-test Between Eo and Ec For Peraf Alff And Falffsupporting

confidence: 92%

“…1) We first provided detailed formation of PerAF by using simulated data. 2) We applied PerAF (mPerAF) to detect voxel-level differences between two resting states (eyes open [EO] vs. eyes closed [EC]) because the differences between EO and EC have been consistently reported in previous RS-fMRI studies [17,[22][23][24][25][26]. 3) We further assessed the test-retest reliability of PerAF (mPerAF).…”

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confidence: 99%

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Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level

et al. 2020

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The amplitude of low-frequency fluctuation (ALFF) measures resting-state functional magnetic resonance imaging (RS-fMRI) signal of each voxel. However, the unit of blood oxygenation level-dependent (BOLD) signal is arbitrary and hence ALFF is sensitive to the scale of raw signal. A well-accepted standardization procedure is to divide each voxel's ALFF by the global mean ALFF, named mALFF. Although fractional ALFF (fALFF), a ratio of the ALFF to the total amplitude within the full frequency band, offers possible solution of the standardization, it actually mixes with the fluctuation power within the full frequency band and thus cannot reveal the true amplitude characteristics of a given frequency band. The current study borrowed the percent signal change in task fMRI studies and proposed percent amplitude of fluctuation (PerAF) for RS-fMRI. We firstly applied PerAF and mPerAF (i.e., divided by global mean PerAF) to eyes open (EO) vs. eyes closed (EC) RS-fMRI data. PerAF and mPerAF yielded prominently difference between EO and EC, being well consistent with previous studies. We secondly performed test-retest reliability analysis and found that (PerAF � mPerAF � mALFF) > (fALFF � mfALFF). Head motion regression (Friston-24) increased the reliability of PerAF, but decreased all other metrics (e.g. mPerAF, mALFF, fALFF, and mfALFF). The above results suggest that mPerAF is a valid, more reliable, more straightforward, and hence a promising metric for voxel-level RS-fMRI studies. Future study could use both PerAF and mPerAF metrics. For prompting future application of PerAF, we implemented PerAF in a new version of REST package named RESTplus. OPEN ACCESS Citation: Jia X-Z, Sun J-W, Ji G-J, Liao W, Lv Y-T, Wang J, et al. (2020) Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level. PLoS ONE 15(1): e0227021. https://doi.org/10.synchronization of the BOLD signals between any pair of brain regions, FC analysis cannot directly measure the regional spontaneous brain activity of a specific voxel per se. Another widely used RS-fMRI measurement, ALFF [2], can be adopted on this purpose, as it provides direct characterization of the spontaneous brain activity at each voxel. However, since BOLD signal has arbitrary units, ALFF is sensitive to the scale of the raw BOLD signal and cannot be directly applied to subsequent group-level statistical analysis.An approach to deal with such a scaling effect is to normalize the raw amplitude value by the global mean amplitude, i.e., the averaged amplitude value across all voxels in the brain [2][3][4]. However, such manipulation assumes that the BOLD signal of all voxels has the same scaling value. In fact, many factors affect the scaling value, including spatial inhomogeneity, brain tissue composition, and brain lesions. Standardization at single voxel level may be helpful to reduce such effects.Another voxel-level metric, namely fractional ALFF (fALFF), had been proposed to normalize ALFF [5]. The fALFF is a ratio of the ALFF within a spec...

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Section: Paired T-test Between Eo and Ec For Peraf Alff And Falffsupporting

confidence: 92%

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confidence: 99%

Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level

et al. 2020

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“…For example, the default mode network can be determined in literally each subject. Among the studies of between-condition comparison within a single group of subjects, differences between EO and EC resting conditions are significantly consistent across studies using FFT-ALFF (Yan et al, 2009;Liu et al, 2013;Zou et al, 2015;Zhao et al, 2018). Most clinical studies correspond to betweengroup comparison.…”

Section: Similarity Of Spatial Pattern Of Wavelet-amplitude Of Low-frmentioning

confidence: 70%

Higher Sensitivity and Reproducibility of Wavelet-Based Amplitude of Resting-State fMRI

et al. 2020

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“…Based on our previous research's methods and acquisition of the brain MRI data, MRI data will be firstly preprocessed and analyzed by SPM12 software performing on MATLAB 8.6 (Math works, Inc., Natick, MA, USA),Brain Voyager QXsoftware (Brain Innovation, The Netherlands) [56]. And then, for accurately investigate the different cerebral responses, including regional homogeneity (ReHo) [57], tract-based spatial statistics (TBSS) [58,59], amplitude of low-frequency fluctuation (ALFF) [60], and functional connectivity (FC) will be used in this study. Finally, correlation analysis will be processed between clinical data and MRI image data.…”

Section: Mri Data Analysismentioning

confidence: 99%

The central mechanism of tadalafil vs Chaihu-Shugan-San capsule for psychogenic erectile dysfunction: a magnetic resonance imaging study protocol of a randomized placebo-controlled trial

Ren

Zhang

et al. 2019

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Background: Erectile dysfunction (ED) affects many adult men worldwide. Many studies on the brain of psychogenic ED have shown significant cerebral functional changes and reduced volume of gray matter and white matter microstructural alterations in widespread brain regions. We design this study to provide both an enhanced level of evidence of central mechanism research and an evidence-based treatment option for patients suffering from psychogenic ED. Furthermore, we also aim to provide a new evidence as well as an innovation of the clinical treatment in psychogenic ED. Method and Analysis: This study is designed as a multi-center, three-arms, randomized trial. From the perspective of psychogenic ED, we will divide patients into three groups, which are placebo group, tadalafil group and CHSGS group. 135 patients will be randomly allocated to receive placebo, CHSGS capsule or tadalafil oral pharmacotherapy. After the period of 4-week treatment, the outcome of primary assessment changes in the IIEF-5, EHS and QEQ total scores from baseline. Secondary assessments include the SEAR, HAMA-14, HAMD-17 scores, response rate of the patients and their partners. Apart from brain MRI from baseline, we will also attach great importance to other changes in the follow-up four weeks. Discussion: We expect that the results of this trial can provide both an enhanced level of evidence for central mechanism research and an evidence-based treatment option for patients suffering from ED, as well as to provide an innovation of the clinical treatment in psychogenic ED.

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Intra- and Inter-Scanner Reliability of Voxel-Wise Whole-Brain Analytic Metrics for Resting State fMRI

Cited by 77 publications

References 34 publications

Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level

Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level

Higher Sensitivity and Reproducibility of Wavelet-Based Amplitude of Resting-State fMRI

The central mechanism of tadalafil vs Chaihu-Shugan-San capsule for psychogenic erectile dysfunction: a magnetic resonance imaging study protocol of a randomized placebo-controlled trial

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