Intra‐ and interday reproducibility of high‐flow‐mediated constriction response in young adults

Ostrem, Joseph D.; Evanoff, Nicholas G.; Ryder, Justin R.; Dengel, Donald R.

doi:10.1111/cpf.12399

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…In fact, peripheral ED is always associated with coronary ED [6]. However, the FMD test has numerous limitations, as changes in the brachial artery caliber are reduced, and numerous technical measures are required to give this method better reproducibility [132]. In order to increase the FMD's reproducibility, additional precautions by the operator should be required.…”

Section: Sglt-2 Inhibitorsmentioning

confidence: 99%

Innovative Treatments to Counteract Endothelial Dysfunction in Chronic Kidney Disease Patients

Marrone,

Cornali,

Di Lauro

et al. 2024

Biomedicines

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In chronic kidney disease (CKD) patients, several risk factors contribute to the development of endothelial dysfunction (ED), which can be described as an alteration in the cell structure or in the function of the endothelium. Among the well-known CKD-related risk factors capable of altering the production of endothelium-derived relaxing factors, we include asymmetric dimethylarginine increase, reduced dimethylarginine dimethylamine hydrolase enzyme activity, low-grade chronic systemic inflammation, hyperhomocysteinemia, oxidative stress, insulin resistance, alteration of calcium phosphorus metabolism, and early aging. In this review, we also examined the most important techniques useful for studying ED in humans, which are divided into indirect and direct methods. The direct study of coronary endothelial function is considered the gold standard technique to evaluate if ED is present. In addition to the discussion of the main pharmacological treatments useful to counteract ED in CKD patients (namely sodium–glucose cotransporter 2 inhibitors and mineralocorticoid receptor antagonist), we elucidate innovative non-pharmacological treatments that are successful in accompanying the pharmacological ones. Among them, the most important are the consumption of extra virgin olive oil with high intake of minor polar compounds, adherence to a plant-dominant, low-protein diet (LPD), an adaptive physical activity program and, finally, ketoanalogue administration in combination with the LPD or the very low-protein diet.

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Section: Sglt-2 Inhibitorsmentioning

confidence: 99%

Innovative Treatments to Counteract Endothelial Dysfunction in Chronic Kidney Disease Patients

Marrone,

Cornali,

Di Lauro

et al. 2024

Biomedicines

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show abstract

“…Future Development and Emerging Approaches-Assessment of high-flow mediated constriction (H-FMC) and low flow-mediated constriction (L-FMC) responses has recently been proposed as a complement to FMD to better discriminate endothelial activation at baseline from true endothelial dysfunction with the combined assessment of vasodilator and vasoconstrictor capacity and their composite endpoint, the vasoactive range (VAR). [141][142][143] H-FMC response has been referred to as the slight reduction in diameter seen immediately after the release of occlusion in some subjects; for the calculation of total brachial artery reactivity, it has been suggested to use the minimum diameter after the release of occlusion as the alternative "baseline" diameter and this parameter has shown an association with cardiovascular diseases. 144 In L-FMC, the constriction response is calculated as the change from the baseline diameter of the lowest diameter during occlusion (usually monitored in around 1 minute time interval before the release of occlusion).…”

Section: Plaque Elasticity and Kinematicsmentioning

confidence: 99%

The Ultrasound Window Into Vascular Ageing: A Technology Review by the VascAgeNet COST Action

Bianchini

Guala

Golemati

et al. 2023

J of Ultrasound Medicine

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Non‐invasive ultrasound (US) imaging enables the assessment of the properties of superficial blood vessels. Various modes can be used for vascular characteristics analysis, ranging from radiofrequency (RF) data, Doppler‐ and standard B/M‐mode imaging, to more recent ultra‐high frequency and ultrafast techniques. The aim of the present work was to provide an overview of the current state‐of‐the‐art non‐invasive US technologies and corresponding vascular ageing characteristics from a technological perspective. Following an introduction about the basic concepts of the US technique, the characteristics considered in this review are clustered into: 1) vessel wall structure; 2) dynamic elastic properties, and 3) reactive vessel properties. The overview shows that ultrasound is a versatile, non‐invasive, and safe imaging technique that can be adopted for obtaining information about function, structure, and reactivity in superficial arteries. The most suitable setting for a specific application must be selected according to spatial and temporal resolution requirements. The usefulness of standardization in the validation process and performance metric adoption emerges. Computer‐based techniques should always be preferred to manual measures, as long as the algorithms and learning procedures are transparent and well described, and the performance leads to better results. Identification of a minimal clinically important difference is a crucial point for drawing conclusions regarding robustness of the techniques and for the translation into practice of any biomarker.

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Intra‐ and interday reproducibility of high‐flow‐mediated constriction response in young adults

Abstract: These data are supportive of H-FMC being reproducible in young adults and included in future FMD studies. The impact of H-FMC on future CVD risk and development warrants evaluation.

Cited by 2 publications

References 28 publications

Innovative Treatments to Counteract Endothelial Dysfunction in Chronic Kidney Disease Patients

Innovative Treatments to Counteract Endothelial Dysfunction in Chronic Kidney Disease Patients

The Ultrasound Window Into Vascular Ageing: A Technology Review by the VascAgeNet COST Action

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