Intra- and interobserver reproducibility of pancreatic perfusion by computed tomography

Garcia, Tiago Severo; Engelholm, J.-L.; Vouche, Michaël; Hirakata, Vânia Naomi; Leitão, Cristiane Bauermann

doi:10.1038/s41598-019-42519-w

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Perfusion CT is a promising technique for assessing tissue viability, biology and detecting small tumors [93][94][95][96][97]. Kinetic modeling of the dynamic acquisition provides quantitative physiological metrics like blood volume (BV), blood flow (BF), time to peak (TTP) and time-attenuation curves (TAC) to detect microvascular changes.…”

Section: Perfusion Ctmentioning

confidence: 99%

Advanced imaging techniques for chronic pancreatitis

Parakh

Tirkes

2019

Abdom Radiol

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MRI and MRCP play an important role in the diagnosis of chronic pancreatitis (CP) by imaging pancreatic parenchyma and ducts. MRI/MRCP is more widely used than computed tomography (CT) for mild to moderate CP due to its increased sensitivity for pancreatic ductal and gland changes; however, it does not detect the calcifications seen in advanced CP. Quantitative MR imaging offers potential advantages over conventional qualitative imaging, including simplicity of analysis, quantitative and population-based comparisons, and more direct interpretation of detected changes. These techniques may provide quantitative metrics for determining the presence and severity of acinar cell loss and aid in the diagnosis of chronic pancreatitis. Given the fact that the parenchymal changes of CP precede the ductal involvement, there would be a significant benefit from developing an MRI/MRCP based, more robust diagnostic criteria combining ductal and parenchymal findings. Among cross-sectional imaging modalities, multi-detector CT (MDCT) has been a cornerstone for evaluating chronic pancreatitis (CP) since it is ubiquitous, assesses primary disease process, identifies complications like pseudocyst or vascular thrombosis with high sensitivity and specificity, guides therapeutic management decisions, and provides images with isotropic resolution within seconds. Conventional MDCT has certain limitations and is reserved to provide predominantly morphological (e.g. calcifications, organ size) rather than functional information. The emerging applications of radiomics and artificial intelligence is poised to extend the current capabilities of MDCT. In this review article, we will review advanced imaging techniques by MRI, MRCP, CT and ultrasound.Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. https://www.springer.com/aamterms-v1 (*)

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Section: Perfusion Ctmentioning

confidence: 99%

Advanced imaging techniques for chronic pancreatitis

Parakh

Tirkes

2019

Abdom Radiol

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“…CT perfusion imaging of the pancreas is a dynamic technique for discerning information on pancreatic vascularity and disease process [1] . Miles et al [2] initially demonstrated the feasibility of pancreatic perfusion studies using dynamic CT and described the principle advantage of combining functional information and high spatial detail in a single study.…”

Section: Introductionmentioning

confidence: 99%

Normative CT perfusion parameters of pancreas in relation to the age and gender

Karegowda¹,

Kadavigere²,

Shenoy³

2021

Int. J. Radiol. Diagn. Imaging

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A variety of inflammatory and neoplastic lesions of pancreas can be characterized and prognosticated by perfusion CT (Computed Tomography). Knowing the normal perfusion values is essential before such values could be interpreted as abnormal. The aim of this study was to obtain a normative data of the perfusion parameters of normal pancreatic parenchyma with respect to the age and gender. Materials and Methods: Total 33 subjects underwent perfusion CT of pancreas. The perfusion parameters like BF (Blood-Flow), PEI (Peak Enhancement Index), TTP (Time to Peak) and BV (Blood-Volume) were obtained by placing an ROI (Region of Interest) on normal pancreas. Descriptive statistics of the perfusion values was tabulated and relationship of perfusion characteristics with age and sex of the subjects were calculated applying Pearson's correlation coefficient. Results: 18 subjects were males and 15 were females. 4 subjects belonged to 20-40 age group, 18 belonged to 40-60 age group and 11 belonged to 60-80 age group. BF fell within a range of 11.0 to 161.2 ml100gm -1 min -1 (Mean ± SD=69.12 ± 36.96), PEI ranged from 23.70 to 165.0HU (Mean ± SD=51.82 ± 26.51), BV ranged from 7.8 to 321.5 ml100gm -1 (Mean ± SD=52.31 ± 54.97) and TTP ranged from 8.0 to 58.30s (Mean ± SD=20.16 ± 9.08). BF showed a negative correlation with the patient's age (r = -.252) on applying the Pearson's correlation coefficient, indicating parenchymal perfusion of the normal pancreas declining with age (p>0.05). The PEI showed a negative correlation with patient's age (P>0.05) and BV and TTP showed appositive correlation with the patient's age (P>0.05). No statistically significant differences were observed in perfusion values of normal pancreatic parenchyma between men and women. Conclusion:Though not statistically significant, a tendency of BF and PEI to reduce with age, BV and TTP to increase with age was observed which require studies with large sample size to determine the true significance.

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“…[11] Some studies have assessed normal values of pancreatic perfusion by CT. [12,13] Pancreatic perfusion impairments have been evaluated in pancreatic [12,[14][15][16][17][18] and hepatic [19] diseases, and modifications of pancreatic perfusion after oncologic therapy have been reported. [20] Satisfactory intra-observer reproducibility of pancreatic perfusion parameters measured by CT, such as time to peak (TTP), blood flow (BF), and blood volume (BV) has already been shown, [21] although experience in performing the readings is essential. erefore, the aim of this study is to compare quantitatively the pancreatic perfusion by CT in T2DM and non-diabetic subjects.…”

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Decrease in Pancreatic Perfusion of Patients with Type 2 Diabetes Mellitus Detected by Perfusion Computed Tomography

Garcia

Engelholm

Vouche

et al. 2021

JCIS

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Objectives: The objectives of the study was to compare pancreatic perfusion by computed tomography in type 2 diabetes and non-diabetic subjects. Material and Methods: In this case–control study, 17 patients with type 2 diabetes and 22 non-diabetic controls were examined with a dynamic 192-slices perfusion computed tomography for estimating pancreatic perfusion parameters. Results: Thirty-nine patients were included (22 with Type 2 diabetes mellitus [T2DM]), with a mean age of 64 years. There were significant differences in some pancreatic perfusion parameters in patients with and without type 2 diabetes. Blood volume (BV) was lower in pancreatic head (with T2DM: 14.0 ± 3.4 vs. without T2DM: 16.1 ± 2.4 mL/100 mL; P = 0.033), pancreatic tail (with: 14.4 ± 3.6 vs. without: 16.8 ± 2.5 mL/100 mL; P = 0.023), and in whole pancreas (with: 14.2 ± 3.2 vs. without: 16.2 ± 2.5 mL/100 mL; P = 0.042). Similar behavior was observed with mean transit time (MTT) in pancreatic head (with: 7.0 ± 1.0 vs. without: 7.9 ± 1.2 s; P = 0.018), pancreatic tail (with: 6.6 ± 1.3 vs. without: 7.7 ± 0.9 s; P = 0.005), and in whole pancreas (with: 6.8 ± 1.0 vs. without: 7.7 ± 0.9 s; P = 0.016). BV in head, tail, and whole pancreas had negative correlations with age (head r: –0.352, P = 0.032; tail r: –0.421, P = 0.031; whole pancreas r: –0.439, P = 0.007), and fasting plasma glucose (head r: –0.360, P = 0.031; tail r: –0.483, P = 0.003; whole pancreas r: –0.447, P = 0.006). In a multivariate linear regression model, HbA1c was independently associated with decrease in BV in whole pancreas (β: –0.884; CI95%: –1.750 to –0.017; P = 0.046). Conclusion: Pancreatic BV and MTT were significantly lower in patients with type 2 diabetes. BV was decreased with older age and poorer glycemic control.

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Intra- and interobserver reproducibility of pancreatic perfusion by computed tomography

Cited by 4 publications

References 37 publications

Advanced imaging techniques for chronic pancreatitis

Advanced imaging techniques for chronic pancreatitis

Normative CT perfusion parameters of pancreas in relation to the age and gender

Decrease in Pancreatic Perfusion of Patients with Type 2 Diabetes Mellitus Detected by Perfusion Computed Tomography

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