Intra- and Interpolyelectrolyte Complexes of Polyampholytes

Kudaibergenov, Sarkyt E.; Nuraje, Nurxat

doi:10.3390/polym10101146

Cited by 48 publications

(34 citation statements)

References 155 publications

(190 reference statements)

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“…At the point of definite charge asymmetry ( f N + > f N − or f N + < f N − ), a globule is divided into two parts, with a pearl‐like chain connecting double‐stranded helical conformations on both ends (Figure 7). The pH‐induced collapse and phase diagrams for the IDPs show that collapse takes place at the isoelectric point (IEP), caused by intrapolyelectrolyte complexation between the oppositely charged sequences within single macromolecules, occurring in both synthetic‐based random and block polyampholytes 26 …”

Section: Structural and Behavioral Similarity Between Synthetic Polyamentioning

confidence: 99%

Synthetic and natural polyampholytes: Structural and behavioral similarity

Kudaibergenov

2020

Polymers for Advanced Techs

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The ability of synthetic polyampholytes to adopt globular, coil, helix, and stretched conformations and to exhibit coil–globule, helix–coil, liquid–liquid, sol–gel phase transitions with respect to internal (structure, composition, charge distribution, hydrophobicity, hydrophilicity, and so forth) and external factors (pH, temperature, ionic strength, thermodynamic quality of solvents, and so forth) is very important in duplicating the structural hierarchy of proteins. In this review, the structural and behavioral similarities between synthetic and natural polymers are analyzed, primarily concentrating on synthetic polyampholytes, amphoteric polypeptides, and intrinsically disordered proteins (IDPs) in order to demonstrate the close relationship. The application aspects of polyampholytes and future opportunities are briefly outlined.

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Section: Structural and Behavioral Similarity Between Synthetic Polyamentioning

confidence: 99%

Synthetic and natural polyampholytes: Structural and behavioral similarity

Kudaibergenov

2020

Polymers for Advanced Techs

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“…Advances in polymer synthesis have enabled the preparation of “patchy” charged polymers containing neutral, zwitterionic, or ampholytic co-monomers. In combination with protein patchiness, this provides a rich design space to develop advanced polyelectrolyte complex materials [43,159]. In particular, the use of patchy polyampholytes and polyelectrolytes has great potential for protein-containing coacervates as the polymer component can potentially be tuned to match the protein surface chemistry [160].…”

Section: Discussionmentioning

confidence: 99%

Macro- and Microphase Separated Protein-Polyelectrolyte Complexes: Design Parameters and Current Progress

2019

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Protein-containing polyelectrolyte complexes (PECs) are a diverse class of materials, composed of two or more oppositely charged polyelectrolytes that condense and phase separate near overall charge neutrality. Such phase-separation can take on a variety of morphologies from macrophase separated liquid condensates, to solid precipitates, to monodispersed spherical micelles. In this review, we present an overview of recent advances in protein-containing PECs, with an overall goal of defining relevant design parameters for macro- and microphase separated PECs. For both classes of PECs, the influence of protein characteristics, such as surface charge and patchiness, co-polyelectrolyte characteristics, such as charge density and structure, and overall solution characteristics, such as salt concentration and pH, are considered. After overall design features are established, potential applications in food processing, biosensing, drug delivery, and protein purification are discussed and recent characterization techniques for protein-containing PECs are highlighted.

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“…One of the unique fundamental property of polyampholytes is the so called isoelectric effect, which takes place at the IEP [28,37,38,39,40,41,42]. Therefore, the feasibility of utilizing such a phenomenon for polyampholyte cryogels was tested.…”

Section: Complexation Of Polyampholyte Cryogels With Transition Mementioning

confidence: 99%

“…In contrast, the synthetic polyampholyte cryogels are specific multifunctional objects and have excellent acid–base or anionic–cationic character as well as demonstrate adequate swelling-deswelling, and collapsing behavior in response to external factors such as temperature, pH, ionic strength, metal ions, the nature and charge of low-molecular-weight anions and cations, the mixture of water–organic solvent, and so forth. Some fundamental properties discovered for water-soluble polyampholytes, such as the antipolyelectrolyte effect and the isoelectric effect [37] were clearly demonstarted in the case of polyampholyte cryogels. The antipolyelectrolyte effect that is related to the unfolding of amphoteric macromolecules at the isoelectric point (IEP) upon addition of low-molecular-weight salts was shown for polyampholyte cryogels (see Figure 6).…”

Section: Comparative Analysis Of Polyampholyte Cryogels With Noniomentioning

confidence: 99%

Physicochemical, Complexation and Catalytic Properties of Polyampholyte Cryogels

Kudaibergenov

2019

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Polyampholyte cryogels are a less considered subject in comparison with cryogels based on nonionic, anionic and cationic precursors. This review is devoted to physicochemical behavior, complexation ability and catalytic properties of cryogels based on amphoteric macromolecules. Polyampholyte cryogels are able to exhibit the stimuli-responsive behavior and change the structure and morphology in response to temperature, pH of the medium, ionic strength and water–organic solvents. Moreover, they can uptake transition metal ions, anionic and cationic dyes, ionic surfactants, polyelectrolytes, proteins, and enzymes through formation of coordination bonds, hydrogen bonds, and electrostatic forces. The catalytic properties of polyampholyte cryogels themselves and with immobilized metal nanoparticles suspended are outlined following hydrolysis, transesterification, hydrogenation and oxidation reactions of various substrates. Application of polyampholyte cryogels as a protein-imprinted matrix for separation and purification of biomacromolecules and for sustained release of proteins is demonstrated. Comparative analysis of the behavior of polyampholyte cryogels with nonionic, anionic and cationic precursors is given together with concluding remarks.

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Intra- and Interpolyelectrolyte Complexes of Polyampholytes

Cited by 48 publications

References 155 publications

Synthetic and natural polyampholytes: Structural and behavioral similarity

Synthetic and natural polyampholytes: Structural and behavioral similarity

Macro- and Microphase Separated Protein-Polyelectrolyte Complexes: Design Parameters and Current Progress

Physicochemical, Complexation and Catalytic Properties of Polyampholyte Cryogels

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