Intra‐arterial chemotherapy for head and neck cancer

Abstract

Although it would appear that there is no difference in outcomes for intra‐arterial (IA) versus intravenous cisplatin chemoradiotherapy, one must consider the technique by which the tumors were infused. The authors used the less effective method of bilateral infusion in 58% of patients compared to <5% by us. This large difference could have affected the outcome thus leaving the value of IA cisplatin infusion in question.

Late follow‐up of the randomized radiation and concomitant high‐dose intra‐arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer

“…As Robbins et al 19 commented in 2010, a limitation of this study is that the prognostic marker human papillomavirus (HPV) status was unknown for many of the patients. Even though its relation in oropharyngeal tumors with improved prognosis gains more evidence, at the time of design of the RADPLAT trial, this issue was of less significance.…”

Cerebral infarction after intraarterial and intravenous chemoradiotherapy for head and neck cancer: A retrospective analysis using a Japanese inpatient database

“…7 A Japanese guideline has referred to intraarterial CRT as one of the feasible treatment options for advanced unresectable maxillary sinus cancer. 5,8 Although the treatment indication for intraarterial CRT is still a matter of debate, [9][10][11] intraarterial CRT has led to significantly better local control in patients with a large tumor (>30 mL) not extending across the midline. 5,8 Although the treatment indication for intraarterial CRT is still a matter of debate, [9][10][11] intraarterial CRT has led to significantly better local control in patients with a large tumor (>30 mL) not extending across the midline.…”

“…Maxillary sinus cancer is considered a good candidate for intraarterial CRT because the feeding artery is usually the maxillary artery, which is accessible transfemorally, and also because the frequency of metastasis is relatively low. 10 Known side effects of chemotherapy (both arterial and venous) include renal, hematological, mucosal, otologic, cardiac/pulmonary, and neurological complications. 10 Known side effects of chemotherapy (both arterial and venous) include renal, hematological, mucosal, otologic, cardiac/pulmonary, and neurological complications.…”

“…Maxillary sinus cancer is considered a good candidate for intraarterial CRT because the feeding artery is usually the maxillary artery, which is accessible transfemorally, and also because the frequency of metastasis is relatively low. 5,8 Although the treatment indication for intraarterial CRT is still a matter of debate, [9][10][11] intraarterial CRT has led to significantly better local control in patients with a large tumor (>30 mL) not extending across the midline. 10 Known side effects of chemotherapy (both arterial and venous) include renal, hematological, mucosal, otologic, cardiac/pulmonary, and neurological complications.…”

Intra-arterial chemoradiotherapy for head and neck cancer

“…They were expected to have a good prognosis even if they received less-intensive therapy. It is, therefore, possible that patient selection and catheterization methodology influenced the results of this trial (57). Although RADPLAT was beneficial for patients with relatively large tumours (≥30 cm 3 ) not extending across the midline in the subgroup analysis (35,58), no follow-up on RADPLAT was undertaken worldwide, except Japan, due to the results of the Dutch trial.…”