Intra-arterial infusion of 5-fluorouracil plus granulocyte–macrophage colony-stimulating factor (GM-CSF) and chemoembolization with melphalan in the treatment of disseminated colorectal liver metastases

Müller, H; Nakchbandi, W; Chatzissavvidis, I; Vàlek, Vlatimil

doi:10.1053/ejso.2001.1193

Cited by 13 publications

(4 citation statements)

References 48 publications

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“…125,126 More recently, granulocyte macrophage colony-stimulating factor (GM-CSF) injection via a hepatic artery followed by chemoembolization was performed for patients with liver metastases of colorectal cancer and uveal melanoma. [127][128][129] In these studies, GM-CSF was administered intraarterially to enhance local anti-tumor immune responses and reduce systemic side effects. Therefore, locoregional cytokine injections using interventional oncology techniques may be better tolerated in patients and may enhance anti-tumor responses during CAR T cell therapy.…”

Section: Adjuvant Strategies For Car T Cells Via Interventional Oncology Techniquesmentioning

confidence: 99%

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Kawakami

Ghosn

Cheema

et al. 2022

Molecular Therapy - Oncolytics

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Adoptive cell therapy with chimeric antigen receptors (CAR) T cells has proven effective for hematologic malignancies, but success in solid tumors has been impeded by poor intratumoral infiltration, exhaustion of effector cells from antigen burden, and an immunosuppressive tumor microenvironment. Results from recent clinical trials and preclinical studies lend promising evidence of locoregional approaches for CAR T cell delivery, priming the tumor microenvironment, and performing adjuvant therapies that sustain T cell activity. Interventional oncology is a subspeciality of interventional radiology where imaging guidance is used to perform percutaneous and catheter-directed procedures for localized, non-surgical therapy or interrogation of solid tumors. Interventional oncology provides unique synergies with immunotherapy, which has been well-studied to improve treatment efficacy while reducing toxicities associated with systemic treatment. Besides aiding in CAR T cell delivery, priming, or the stimulation of the tumor microenvironment to promote effector survival and function, interventional oncology can also aid in the monitoring of treatment response through selective, multiplex tumor sampling and catheter-based venous sampling. This review presents an overview of interventional oncology, its various procedures, and its potential for advancing CAR T cell immunotherapy of solid tumors.

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Section: Adjuvant Strategies For Car T Cells Via Interventional Oncology Techniquesmentioning

confidence: 99%

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Kawakami

Ghosn

Cheema

et al. 2022

Molecular Therapy - Oncolytics

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“…Metastases confined to the liver are very common in the course of colorectal disease: 60-70% of all patients with colorectal carcinoma will develop liver metastases during their life, and only around 10% of all cases are resectable [15,29]. Right now, systemic chemotherapy is commonly used in the case of disseminated and unresectable metastases, and results have been improved in recent years with the use of new cytostatics, such as irinotecan or oxaliplatin, and new protocols.…”

Section: Colorectal Liver Metastasesmentioning

confidence: 99%

Curative and palliative aspects of regional chemotherapy in combination with surgery

Müller¹,

Hilger

2003

Support Care Cancer

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Many attempts have been made in the last two decades to improve the outcome of patients with advanced or metastasised solid tumours. In particular, combined-modality treatment strategies combining surgery with more localised therapies, e.g. radiotherapy, or systemic therapies such as chemotherapy have yielded promising data. The aim of regional chemotherapy is to improve locoregional cytostatic drug concentrations by achieving greater local efficacy and to diminish systemic side effects by reducing plasma drug levels. Highly qualified and experienced exponents of regional chemotherapy can complement surgical measures by applying multimodal strategies, because of their high efficacy in terms of tumour mass reduction without

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“…For patients who were not candidates for administration of melphalan via IHP, we hypothesized that melphalan could be administered by hepatic artery infusion. Infusion of melphalan into the hepatic artery has been evaluated in animal studies and used for treatment of liver metastases from ovarian and colon cancer . To our knowledge hepatic artery infusion of melphalan has not been described for the treatment of ocular melanoma metastases.…”

Section: Introductionmentioning

confidence: 99%

“…Infusion of melphalan into the hepatic artery has been evaluated in animal studies 20,21 and used for treatment of liver metastases from ovarian and colon cancer. [22][23][24] To our knowledge hepatic artery infusion of melphalan has not been described for the treatment of ocular melanoma metastases. We sought to determine the safety and feasibility of hepatic artery infusional delivery of melphalan in patients with unresectable liver metastases that had contraindications to IHP.…”

mentioning

confidence: 99%

Hepatic artery infusion of melphalan in patients with liver metastases from ocular melanoma

Boone

Perkins

Bandi

et al. 2018

Journal of Surgical Oncology

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Intra-arterial infusion of 5-fluorouracil plus granulocyte–macrophage colony-stimulating factor (GM-CSF) and chemoembolization with melphalan in the treatment of disseminated colorectal liver metastases

Cited by 13 publications

References 48 publications

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Curative and palliative aspects of regional chemotherapy in combination with surgery

Hepatic artery infusion of melphalan in patients with liver metastases from ocular melanoma

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