Intra-arterial injection of acrylic cement as a complication of percutaneous vertebroplasty

Mozaffar, Mohammad; Radpay, Mohammad Reza; Zirakzadeh, Hatef; Nabavizadeh, Pooneh; Sobhiye, Mohammad Reza; Langroudi, Rouzbeh Motiei

doi:10.1016/j.jvs.2012.04.010

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…Since a loss of C/EBPβ promotes EMT in mammary epithelial cells [ 33 ], it is tempting to speculate that augmentation of C/EBPβ in miR-155 KO mice, as we have found, might also contribute to an attenuation of fibrosis in our model. The regulation of fibrosis by miR-155 likely occurs at multiple levels, and it is not restricted to NASH-fibrosis; for example, we also found a reduction of carbon-tetrachloride induced-fibrosis in miR-155 deficient mice [ 56 ]. In addition to miR-155, numerous other microRNAs can affect liver fibrosis, including miR-122.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis

et al. 2015

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Background & AimMicroRNAs (miRs) regulate hepatic steatosis, inflammation and fibrosis. Fibrosis is the consequence of chronic tissue damage and inflammation. We hypothesized that deficiency of miR-155, a master regulator of inflammation, attenuates steatohepatitis and fibrosis.MethodsWild type (WT) and miR-155-deficient (KO) mice were fed methionine-choline-deficient (MCD) or -supplemented (MCS) control diet for 5 weeks. Liver injury, inflammation, steatosis and fibrosis were assessed.ResultsMCD diet resulted in steatohepatitis and increased miR-155 expression in total liver, hepatocytes and Kupffer cells. Steatosis and expression of genes involved in fatty acid metabolism were attenuated in miR-155 KO mice after MCD feeding. In contrast, miR-155 deficiency failed to attenuate inflammatory cell infiltration, nuclear factor κ beta (NF-κB) activation and enhanced the expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and monocyte chemoattractant protein-1 (MCP1) in MCD diet-fed mice. We found a significant attenuation of apoptosis (cleaved caspase-3) and reduction in collagen and α smooth muscle actin (αSMA) levels in miR-155 KO mice compared to WTs on MCD diet. In addition, we found attenuation of platelet derived growth factor (PDGF), a pro-fibrotic cytokine; SMAD family member 3 (Smad3), a protein involved in transforming growth factor-β (TGFβ) signal transduction and vimentin, a mesenchymal marker and indirect indicator of epithelial-to-mesenchymal transition (EMT) in miR-155 KO mice. Nuclear binding of CCAAT enhancer binding protein β (C/EBPβ) a miR-155 target involved in EMT was significantly increased in miR-155 KO compared to WT mice.ConclusionsOur novel data demonstrate that miR-155 deficiency can reduce steatosis and fibrosis without decreasing inflammation in steatohepatitis.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis

et al. 2015

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“…We have read with keen interest the paper by Mozaffar et al on "Intra-arterial injection of acrylic cement as a complication of percutaneous vertebroplasty." 1 The authors state that this is the first report of intra-arterial embolization of cement. In 2009, however, we had published a case report of peripheral arterial embolization of cement during revision spine surgery.…”

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confidence: 86%

Regarding "Intra-arterial injection of acrylic cement as a complication of percutaneous vertebroplasty"

Kakisis

Soultanis

2013

Journal of Vascular Surgery

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“…PMMA subcutaneous injections local complications are nodules, filler migration and granulomas. Mostly described following percutaneous vertebroplasty systemic complications include pulmonary embolism, 2 pulmonary embolism with ARDS, 3 ventricular perforation, 4 intracardiac embolism, 5 aortic embolism, 6 renal embolism 7 and deep vein thrombosis. 8 Our patient never had fever.…”

Section: Shock Following Subcutaneous Injections Of Polymethylmethacrmentioning

confidence: 99%

Shock following subcutaneous injections of polymethylmethacrylate

et al. 2015

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Intra-arterial injection of acrylic cement as a complication of percutaneous vertebroplasty

Cited by 12 publications

References 8 publications

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis

Regarding "Intra-arterial injection of acrylic cement as a complication of percutaneous vertebroplasty"

Shock following subcutaneous injections of polymethylmethacrylate

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