Intra-arterial interleukin-12 gene delivery combined with chemoembolization: anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model

Xia, Xiangwen; Li, Xin; Gao, Feng; Zheng, Chuansheng; Liang, Huimin; Zhou, Guofeng

doi:10.1177/0284185113480072

Cited by 15 publications

(6 citation statements)

References 30 publications

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“…Secondary HCC, also known as metastatic HCC, refers to the invasion and metastasis of malignant tumors originated from multiple organs to the liver. Primary HCC is more common, refers to the malignant tumor originated from the liver epithelial or mesenchymal tissue [11] . At present, the pathogenesis of primary HCC is not clear and its risk factors mainly include hepatitis B virus infection, liver cirrhosis, family history of cancer, alcoholism, bad eating habits and so on [12] .…”

Section: Resultsmentioning

confidence: 99%

Effects of Ginsenosides on Microvascular and Immune Microenvironment and Prognosis of Hepatocellular Carcinoma

Wang¹,

Cai²,

Li³

et al. 2021

ijps

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Wang et al.: Effects of Ginsenosides on Hepatocellular CarcinomaTo investigate the effects of ginsenosides on the microvascular and immune microenvironment of hepatocellular carcinoma rats and analyzes the relationship on the prognosis of patients with hepatocellular carcinoma. 60 patients with hepatocellular carcinoma were collected and randomly divided into control and treatment group in our hospital from January 2018 to January 2020 and clinical symptoms improvement and adverse reactions were compared and analyzed. 60 rats were randomly divided into ginsenoside, control and model group. The immune cell infiltration and microvascular density were detected and analyzed. In animal studies, the infiltration of cluster of differentiation 3 + , cluster of differentiation 4 + , cluster of differentiation 8 + and forkhead box P3 + T lymphocytes increased significantly while the transforming growth factor beta 1 value decreased significantly after treatment with ginsenoside. Clinically, the patients in the treatment group showed significant improvement in their conscious symptoms and higher treatment efficiency while the adverse reactions such as decrease of white blood cell, decrease of hemoglobin, decrease of platelet, nausea and vomiting and low fever than that of in control group. In hepatocellular carcinoma model, ginsenosides induced lymphocyte infiltration and inhibited tumor angiogenesis to exert anti-tumor effects. And ginsenoside has both anti-tumor and quality of life effects and has good efficacy in the treatment of advanced primary hepatocellular carcinoma.

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Section: Resultsmentioning

confidence: 99%

Effects of Ginsenosides on Microvascular and Immune Microenvironment and Prognosis of Hepatocellular Carcinoma

Wang¹,

Cai²,

Li³

et al. 2021

ijps

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show abstract

“…The VX2 tumor model is frequently used by interventional radiologists for studies of liver, [5][6][7] kidney, 20 uterine, 21 and lung 22 tumors. The rabbit VX2 liver tumor model in particular has been extensively used in research regarding various aspects of liver cancer and is commonly recognized as the liver tumor inoculation model for liver cancer.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

Cheng¹,

Zhang²,

Wang³

et al. 2022

Diagn Interv Radiol

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“…The VX2 cell line was originally derived from a rabbit carcinosarcoma but closely resembles human HCC from a biological standpoint ( Nass et al, 2017 ) and thus serves as a useful model for the study of imaging ( Kim et al, 2014 ) and treatments ( Xia et al, 2013 ) of HCC. Currently, the VX2 rabbit liver tumor model is usually produced via laparotomy or ultrasound-guided inoculation.…”

Section: Discussionmentioning

confidence: 99%

Intravoxel incoherent motion diffusion-weighted imaging and shear wave elastography for evaluating peritumoral liver fibrosis after transarterial chemoembolization in a VX2 rabbit liver tumor model

Cheng

Yang

et al. 2022

Front. Physiol.

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In this study, we sought to evaluate changes in peritumoral fibrosis after transarterial chemoembolization (TACE) in a rabbit VX2 liver tumor model using intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) and ultrasound shear wave elastography (SWE). A total of 20 rabbits underwent implantation of VX2 tumor tissues in the left lobe of the liver. The rabbits were randomly divided into an experimental group (n = 10) or a control group (n = 10). Those in the experimental group were treated with an emulsion of lipiodol and pirarubicin through a microcatheter 2–3 weeks after implantation; those in the control group were treated with sterile water. Compared with the control group, the true diffusion coefficient (D) and pseudodiffusion coefficient (D*) values in liver tissues were significantly lower (p < 0.05 for all) and liver stiffness values (LSV) (10.58 ± 0.89 kPa) were higher in the experimental group (7.65 ± 0.86 kPa; p < 0.001). The median stage of liver fibrosis based on METAVIR scores was 1 (1,1) in the control group and 2 (2,3) in the experimental group (Z = 4.15, p < 0.001). D, D*, and LSV were significantly correlated with pathologic staining in the assessment of liver fibrosis (r = −0.54 p = 0.015; r = −0.50, p = 0.025; r = 0.91, p < 0.001; respectively). These data suggest that TACE aggravates liver injury and liver fibrosis, especially surrounding the tumor, in a rabbit VX2 liver tumor model. IVIM DWI and SWE can be used to evaluate the change in liver fibrosis.

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Intra-arterial interleukin-12 gene delivery combined with chemoembolization: anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model

Abstract: Intra-arterial interleukin-12 gene therapy combined with TACE has a potent anti-tumor effect in rabbit VX2 liver cancer in comparison with TACE alone.

Cited by 15 publications

References 30 publications

Effects of Ginsenosides on Microvascular and Immune Microenvironment and Prognosis of Hepatocellular Carcinoma

Effects of Ginsenosides on Microvascular and Immune Microenvironment and Prognosis of Hepatocellular Carcinoma

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

Intravoxel incoherent motion diffusion-weighted imaging and shear wave elastography for evaluating peritumoral liver fibrosis after transarterial chemoembolization in a VX2 rabbit liver tumor model

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