Intra-arterial treatment with 90Y microspheres for hepatocellular carcinoma: 4 years experience at the Ghent University Hospital

Abstract

Following a strict workup before admitting patients to radioembolization with TheraSphere, we found good clinical tolerance in the vast majority of patients. Radiological response assessment yielded an overall response rate of 50%, when evaluated early following treatment. Urine analysis showed consistently only low activities of (90)Y excreted in the urine.

90Y ‐PET imaging: Exploring limitations and accuracy under conditions of low counts and high random fraction

“…Microspheres are blocked in the capillaries and deliver the therapeutic effect of 90 Y ionizing radiations ( β − disintegration) locally (E β max = 2.2 MeV, maximum range in water: 11 mm). 1 SIRT is indicated in nonresectable liver cancer with or without portal vein thrombosis, which makes it a good alternative to liver directed procedures such as transarterial chemoembolization. 2,3 There is considerable interest in performing SIRT dosimetry.…”

Radioembolisation of hepatocellular carcinoma patients using 90Y-labelled microspheres: towards a diffusion of the technique?

“…In conclusion, the study presented by Lambert et al in this issue [1] appears to provide key data regarding the feasibility, efficacy and safety of radioembolisation using 90 Y-labelled glass microspheres in HCC patients. Although the implementation of this new therapeutic approach is more complex, its safety profile appears superior to that of 131 I-Lipiodol, on account of the prior diagnostic angiography performed to identify patients at risk of developing pulmonary or gastroduodenal complications.…”

“…The trial performed by Lambert et al and published in the current issue of the European Journal of Nuclear Medicine and Molecular Imaging [1] is the third European feasibility study on the use of glass microspheres in the setting of HCC, while most of the other studies were conducted by a few North American teams with substantial experience in this research area. Their report confirms that this technique may be utilised by teams with no prior experience in the use of microspheres, without major complications and with comparable efficacy results.…”

90Y Radioembolization: Multimodality Imaging Pattern Approach with Angiographic Correlation for Optimized Target Therapy Delivery

“…Failure to identify providing intra-arterial therapies for liver tumors (1,2,4,5,7,13,19,20). Radioembolization and the integration of combination therapies have improved response rates and the survival of patients with liver neoplasms (21)(22)(23)(24).…”