Intra-articular glucocorticoid injections in patients with juvenile idiopathic arthritis in a Singapore hospital

Leow, Olivia Min Yi; Lim, Lee Kean; Ooi, Pei Ling; Ang, Elizabeth; Son, Mary Beth F.

doi:10.11622/smedj.2014066

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…Ravelli et al (8) reported that 52% of children achieved remission in injected joints, similar to Neidel et al (9) and Cuncha et al (10) who reported full remission of joint inflammation in 58-82% and more than 50% of large joints of children enrolled in their study. As TH has a lower solubility compared to TA, its absorption from the injected joint is slower, thereby maintaining synovial levels for a longer period, which may account for its enhanced efficacy (2,11,12). The results obtained by Zulian et al (13) clearly showed that after 6 months 81.4% of joints injected with TH and 53.3% of joints injected with TA had no sign of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease of unknown cause, most common in childhood and a significant cause of disability in children (1). Various therapeutic options have been recommended to control inflammation and prevent permanent loss of joint function (2). The intraarticular steroids (IASs) are a commonly used option for the treatment in children with JIA with a small number of affected joints as well as an effective way to reduce and/or avoid the use of systemic drugs, to treat an arthritis flare in children already maintained on second-line agents (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Ćosićkić

Alić

Suljendić

et al. 2021

Sanamed

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Aim: To evaluate the therapeutic response to triamcinolone acetonide (TA) and triamcinolone hexacetonide (TH) injections in the knee of children with JIA. Material and methods: 46 joints of 42 children undergoing intra-articular injections were randomly treated with either TH or TA depending on the availability of the drug. A good response was defined as the decrease in articular score of 60% from the base-line and the ultrasound absence of synovitis. Clinical, laboratory variables were noted to examine possible predictive factors of the result. Results: Of 42 children with JIA, the most common was the oligoarticular persistent form in 24 (57.1%) children. Six-month remission was observed in 21.4% of children, TA vs. TH: 36.8% vs. 8.7% (p = 0.02). The absence of signs of knee inflammation within 12 months was found in 23.8% of children, after the application of TA vs. TH: 31.6% vs. 17.4% (p = 0.28). However, long-term, a twenty-four-month remission was achieved in 52.4% of children-in twice as many children after TH (69.9%) than after TA application (31.6%) (p = 0.03). A statistically significant correlation was observed between articular score values and duration of remission after TH application, (r = 0.56, p = 0.006; 95%CI: 0.145-0.80). Two children developed side effects in the form of subcutaneous atrophy at the site of injection, one girl developed transient crystal synovitis after TH applications. Conclusion: This study has shown that intraarticular steroid injections are safe for the treatment of joint inflammation in JIA, and TA is effective in short-term follow-up where TH is an optimum choice in long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Ćosićkić

Alić

Suljendić

et al. 2021

Sanamed

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“…This is supported by an audit on intra-articular steroid injections performed in JIA patients in NUH. (4) The audit showed that joint injections were performed only once in 80.8% of patients with good clinical response and that no incidence of septic arthritis or avascular necrosis was recorded. Physiotherapy and occupational therapy complement therapeutic effort to achieve complete disease quiescence, enabling the child to have a normal life and function.…”

mentioning

confidence: 99%

Paediatric rheumatology: a subspecialty in its infancy that is making leaps and bounds

Ooi¹

2014

smedj

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Paediatric rheumatology is an exciting field exploding with new knowledge of autoimmune and autoinflammatory conditions and how to treat them. It is, however, a relatively new subspecialisation in Asia. There is thus a great need to educate the public and medical community about paediatric rheumatic diseases so that children with such conditions are given the highest possibility of achieving normal function in their daily lives.

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Comment on “Hip involvement in children with enthesitis-related arthritis (ERA) is associated with poor outcomes in adulthood”

2022

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Intra-articular glucocorticoid injections in patients with juvenile idiopathic arthritis in a Singapore hospital

Cited by 9 publications

References 21 publications

Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Paediatric rheumatology: a subspecialty in its infancy that is making leaps and bounds

Comment on “Hip involvement in children with enthesitis-related arthritis (ERA) is associated with poor outcomes in adulthood”

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