Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

Jørgensen, Anette; Stengaard‐Pedersen, Kristian; Simonsen, Ole; Pfeiffer-Jensen, Mogens; Eriksen, Christian; Bliddal, Henning; Pedersen, Niels Wisbech; Bødtker, Søren; Hørslev‐Petersen, Kim; Snerum, Lennart; Egund, Niels; Frimer-Larsen, Helle

doi:10.1136/ard.2009.118042

Cited by 79 publications

(59 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They participated in a multicenter RCT study examining the eYcacy and safety of Wve intra-articular hyaluronan injections at Aarhus University Hospital [14]. Inclusion criteria were among others moderate to severe disease activity with a Lequesne index score of¸10, CRP in normal range and negative IgM-RF.…”

Section: Patientsmentioning

confidence: 99%

Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

et al. 2011

View full text Add to dashboard Cite

The innate immune system contributes to the development of rheumatoid arthritis (RA). A potent contributor to such processes is the complement system. The complement system is known to be activated in the inflammatory phases of osteoarthritis (OA). The lectin pathway of the complement system is activated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or one of the three ficolins in collaboration with MBL-associated serine proteases (MASPs). We assessed the lectin pathway in plasma and synovial fluid (SF) of 27 RA patients and 30 OA patients by measuring MBL, MASP-2, MASP-3, M-ficolin, and H-ficolin. The concentration for all 5 proteins was significantly higher in plasma than in SF (P < 0.001) and the concentration in paired plasma and SF samples correlated in both RA and OA (significance levels between <0.001 and 0.02). The ratio of SF/plasma concentration was for all proteins significantly elevated in RA compared with OA patients (all P < 0.001). The M-ficolin concentration correlated with the neutrophils in both plasma (P = 0.01) and SF (P < 0.001) of RA, and in plasma of 78 controls (P = 0.03). To our knowledge, this is the first report on these proteins in SF, except for MBL where our results are in contrast to the one previous publication. The results support an important physiological role of the neutrophils in determining the M-ficolin levels in both RA and healthy adults. We suggest that quantifications of white blood cells should be included in future clinical investigations of M-ficolin.

show abstract

Section: Patientsmentioning

confidence: 99%

Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The efficacy of hyaluronan viscosupplementation has been analyzed in numerous randomized controlled trials, and overall there is consistency of positive clinical benefit in terms of pain relief and improved function [131][132][133][134] with few deleterious side effects. However, statistically significant clinical benefit has not always been shown and duration of improvement appears to be one year or less [135,136]. While hyaluronan viscosupplementation may not be sufficient by itself to treat articular cartilage degeneration, it may offer promise in conjunction with exogenous cell based therapies, by enhancing the pro-chondrogenic environment within the joint.…”

Section: Induced Pluripotent Stem Cell (Ipsc)-derived Chondrogenic Cellsmentioning

confidence: 99%

The Potential of Human Embryonic Stem Cells for Articular Cartilage Repair and Osteoarthritis Treatment

Fisher

Ferrari²,

Li³

et al. 2012

Rheumatol Curr Res

View full text Add to dashboard Cite

Osteoarthritis is a debilitating joint disease present in epidemic proportions worldwide. Osteoarthritis results from degeneration of the articular cartilage of the joint surfaces due to acute trauma, or chronic wear and tear. Due to limited ability of cartilage to repair itself, and lack of available treatments, there is an urgent need for development of approaches to repair articular cartilage damage due to injury or osteoarthritic disease. Cell-based repair strategies are among the most promising of these approaches. Various adult cell sources for cartilage repair are proposed including autologous adult chondrocytes as well as adult Mesenchymal Stem Cells (MSC). Disadvantages such as destructive harvest protocols; poor proliferation, and particularly for MSC, considerable cellular heterogeneity, have limited success of these cell types for cartilage repair. Chondrogenic cells derived from human embryonic stem cells (hESC) offer a highly proliferative cell source, which when directed into the chondrogenic lineage, could provide an ideal source of cells for cartilage repair. Chondrogenic cells derived from human induced pluripotent stem cells (iPSC) offer additional advantages for patient-specific therapy. Recently protocols have been established for directed differentiation of hESC into the chondrogenic lineage. Harnessing the potential of hESC-derived chondrogenic cells will require comprehensive testing of their efficacy for in vivo cartilage repair, as well as considerations of safety and immunogenicity of the cells. Use of pro-chondrogenic factors and/or bioactive scaffolds may assist in optimizing cartilage repair by chondrogenic cells. Repair of cartilage damage in osteoarthritis is a special challenge because of the widespread damage and presence of signals and stressors which disrupt normal joint homeostasis. Particular promise in cell-based repair of osteoarthritis may be provided by chondrogenic progenitor cells which may mimic endogenous repair responses. This review discusses the current status of cell-based cartilage repair strategies and in particular the potential role of hESC-derived chondrocytes or chondroprogenitor cells for treatment of articular cartilage damage due to injury and osteoarthritis.

show abstract

“…The results were found to be no better than placebo (LOE Ib). [65] There have been a number of trials performed in our country on this subject. In one of these, five consecutive weeks of IHA administration in patients with knee OA was evaluated, and the results were also found to be no better than placebo (LOE Ib).…”

Section: Nonselective and Selective Nonsteroidal Antiinflammatory Drumentioning

confidence: 99%

Evidence-Based Recommendations for the Management of Knee Osteoarthritis: A Consensus Report of the Turkish League Against Rheumatism

et al. 2012

View full text Add to dashboard Cite

Amaç: Diz osteoartriti (OA) sık görülen ve neden olduğu ağrı ve sakatlık sonucunda sosyoekonomik yük bindiren bir hastalıktır. Türkiye Romatizma Araştırma ve Savaş Derneği (TRASD) OA tedavisi ile uğraşan hekimlere günlük klinik uygulamalarında yardımcı olmak amacıyla, uzman görüşleri ile desteklenmiş, ulusal "diz osteoartrit tedavisinde kanıta dayalı önerileri" hazırlamak için bir proje başlatmıştır. Objectives: Knee osteoarthritis (OA) is a common disease which causes pain, disability and great socioeconomic burden as a result. Turkish League Against Rheumatism (TLAR) initiated a project to prepare national, "evidence-based recommendations for the management of knee osteoarthritis" supported by expertopinion in order to assist the physicians who are interested in knee OA in their daily clinical practice. Gereç ve yöntemler: Materials and methods:The expert committee was composed of 25 academicians, 23 of whom were physical medicine and rehabilitation (PM&R) specialists (three also had rheumatology subspeciality) and two were orthopedic surgeons. At the first meeting, the previous guidelines were discussed, and 2008 Osteoarthritis Research Society International (OARSI) recommendations were decided to be taken as the fundamental template for national recommendations. Databases of the Pubmed, Embase, Cochrane, and Turkish Medical Index were used to search the literature, and this was carried out for the period between 2009-2010 for international publications since studies up to 2009 were present in the 2010 OARSI update. No limit was applied for searching of national publications. The selected relevant publications were graded according to evidence level and quality, and were sent to the members who were then asked to suggest propositions according to their experiences, knowledge, and review of the literature. After amalgamation and editing of new proposals, Delphi rounds were started. After five Delphi rounds, the propositions on which the members were in consensus, were discussed with regard to evidence and the "strength of recommendation" was determined by measuring on visual analog scale (VAS) for each proposal at the final meeting.Results: Nineteen propositions (one for general principles, nine for nonpharmacologic treatments, seven for pharmacologic treatments, and two for surgical treatments) were accepted as the "TLAR Evidence-Based Recommendations for the Management of Knee OA" in consensus as a result of Delphi rounds. Conclusion:Evidence-based recommendations for the management of knee OA were developed by TLAR for the first time in our country. The recommendations should be updated regularly according to new evidence and insights. It is expected that physicians who are interested in knee OA will benefit greatly from this report in their daily clinical practice.

show abstract

Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

Cited by 79 publications

References 31 publications

Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

The Potential of Human Embryonic Stem Cells for Articular Cartilage Repair and Osteoarthritis Treatment

Evidence-Based Recommendations for the Management of Knee Osteoarthritis: A Consensus Report of the Turkish League Against Rheumatism

Contact Info

Product

Resources

About