Intra-Articular Injection of an Extracellular Vesicle Isolate Product to Treat Knee Osteoarthritis in an Athlete

Abstract

The patient is a 51 years old athlete with a 2 ½ yr. history of increasing left medial and patella-femoral knee pain. He had previously failed two arthroscopic procedures, a hyaluronic acid and PRP injections. MRI and arthroscopy indicated Kellgren-Lawrence grade three arthritis in the medial femoraltibial and patellofemoral areas of the knee joint. He underwent a single injection of bone marrow-derived mesenchymal stem cell EVIP (ExoFlo Direct Biologics, St. Louis MO) containing active growth factors (over 800) and exosomes (0ver 10 Billion per cc). Within two weeks he had returned to normal activities. At six-month follow-up he feels his overall improvement is 75%. His improvement at six-month follow-up in BPI was 96%, ODI 84% and LEFS 59%. There were no complications with the injection.