Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management

Wen, Juan; Li, Huimin; Dai, Huan; Hua, Shu; Long, Xing; Li, Huang; Ivanovski, Sašo; Xu, Chun

doi:10.1016/j.mtbio.2023.100597

Cited by 39 publications

(27 citation statements)

References 198 publications

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“…[4][5][6] Consequently, this leads to reduced mobility and a subsequent decrease in the quality of life, and a substantial economic burden due to ongoing costs of treatment. 7 OA, a prevalent age-related degenerative disease, affected over 595 million individuals globally in 2020. Generally, it exhibits a higher prevalence among women as compared to men.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment

Nah,

Sobha,

Saravanakumar

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment

Nah,

Sobha,

Saravanakumar

et al. 2024

Biomater. Sci.

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“…The former, direct therapeutic biomaterials, possess an array of remarkable attributes, encompassing minimal toxicity, remarkable biocompatibility and biodegradability, streamlined structure, and economical production costs. [21] Drug delivery systems accelerate drug to penetrate biological barriers, promote drug to target lesion sites, extend drug half-life, increase pharmacodynamic of drug, and achieve precise and on-demand Tailoring biomaterials ameliorate inflammatory bone loss. Inflammatory diseases induce bone loss, which is amended by the delivery system, nanodecoy, photothermal agent, gas donor, scaffold, membrane, enzyme, scavenger, and biomimetic biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon us more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, we list the advances of biomaterials for ameliorating inflammatory bone loss. Additionally, we summarize the advantages and disadvantages of various biomaterials‐mediated strategies. Finally, we analyze the challenges and perspectives of biomaterials. This review aims to provide new possibilities for developing more advanced biomaterials towards inflammatory bone loss.This article is protected by copyright. All rights reserved

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“…40 More importantly, nanostructure-based drug carriers can improve the efficacy of the intra-articular injection by controlling the drug release, extending the drug retention time, and enhancing the drug penetration into the joint tissues. 28,41 In this study, a HA−peptide conjugate, HA−FmocFF polymer, was synthesized and coassembled with Cur. Interestingly, FmocFF-modified HA displayed a vesicular structure, as shown in Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, intra-articular administration is less frequent because the delivery system is able to consistently release the drug . More importantly, nanostructure-based drug carriers can improve the efficacy of the intra-articular injection by controlling the drug release, extending the drug retention time, and enhancing the drug penetration into the joint tissues. , …”

Section: Introductionmentioning

confidence: 99%

Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy

Zhang

Wei

et al. 2023

Biomacromolecules

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes endless pain and poor quality of life in patients. Usage of a lubricant combined with anti-inflammatory therapy is considered a reasonable and effective approach for the treatment of RA. Herein, inspired by glycopeptides, a peptidedecorated hyaluronic acid was synthesized, and the grafted Fmocphenylalanine-phenylalanine-COOH (FmocFF) peptide self-assembled with β-sheet conformations could induce the folding of polymer molecular chains to form a vesicle structure in aqueous solution. The hydrophobic anti-inflammatory drug curcumin (Cur) could be embedded in the vesicle walls through π−π interactions with the FmocFF peptide. Furthermore, the inflammation suppression function of the Cur-loaded vesicles both in vitro and in vivo was demonstrated to be an effective treatment for RA therapy. This work proposes new insights into the folding and hierarchical assembly of glycopeptide mimics, providing an efficient approach for constructing intelligent platforms for drug delivery, disease therapy, and diagnostic applications.

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Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management

Cited by 39 publications

References 198 publications

Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment

Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy

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