“…Most of the studies reviewed here, however, did not discuss the use of antibiotic prophylaxis [6,8,9,11,12,14,16,22,24,[26][27][28] or reported that either all [10,17,25] or none [13] of the infected patients received it. Wieck et al [18] attempted to address the issue of the use of antibiotic prophylaxis by performing a randomized, placebocontrolled, double-blinded trial of 437 patients, and they found no deep infections, although the sample size was small.…”