Intra-articular urokinase in rheumatoid arthritis.

Fibrinolysis is down-regulated in mouse collagen-induced arthritis, but its normalization does not alleviate the course of disease

“…There are some case reports of RA treatments with uPA [40,41] or heparin [42], with either positive or no effect of such treatment. In light of our study, further attempts of exogenous supplementation of plasminogen activators appear to be ungrounded.…”