Intra-gastrically administration of Stevia and particularly Nano-Stevia reversed the hyperglycemia, anxiety, and memory impairment in streptozotocin-induced diabetic rats

Khakpai, Fatemeh; Naseroleslami, Maryam; Moheb-Alian, Marzieh; Ghanimati, Elham; Abdollah-pour, Faezeh; Niri, Neda Mousavi

doi:10.1016/j.physbeh.2023.114100

Cited by 7 publications

(2 citation statements)

References 58 publications

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“…This is mainly due to the glycosides content [ 2 ]. Stevia leaf glycosides are calorie-free and have a nearly zero glycemic index, making them suitable for individuals with diabetes and those aiming to lose weight [ 3 , 4 ]. Stevia sugar is widely used in the food and beverage industries as well as for its antibacterial and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

In vitro propagation of Indonesian stevia (Stevia rebaudiana) genotype using axenic nodal segments

Jadid,

Anggraeni,

Ramadani

et al. 2024

BMC Res Notes

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Objective The high industrial demand for Stevia cultivation (Stevia rebaudiana) has increased due to its high stevioside content derived from the leaves. However, the low germination rate makes the cultivation of the plant become the main obstacle. Therefore, an efficient cultivation technique is required. This present work aims to analyze the effect of five combinations of Kinetin (Kin) and benzyladenine (BA) on stevia micropropagation using nodal segment explants. Results The micropropagation of stevia was performed using Murashige and Skoog (MS) medium supplemented with BA and Kin. We analyzed different organogenesis and callogenesis responses. In addition, the number of shoots and root formed during in vitro culture were also observed. Our results demonstrated that all treatments with Kin, both alone and in combination with BA, resulted in the development of callus on all nodal segment explants. Explants treated in MS with 1 mg L−1 BA exhibited the best average of shoot number (36.27). In contrast, the treatment without PGR resulted in the best root formation (2.6). The overall results suggested that different combination of BA and Kin resulted in distinct organogenesis responses, where 1 mg L−1 of BA was potentially used for boosting the number of shoots in micropropagation of stevia accession Mini.

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Section: Introductionmentioning

confidence: 99%

In vitro propagation of Indonesian stevia (Stevia rebaudiana) genotype using axenic nodal segments

Jadid,

Anggraeni,

Ramadani

et al. 2024

BMC Res Notes

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show abstract

“…Finalmente, la Stevia (Stevia rebaudiana Bertoni) es un edulcorante natural y saludable que se ha utilizado como alternativa al azúcar debido a sus propiedades edulcorantes sin calorías y bajo índice glucémico (Khakpai et al, 2023), siendo su nivel de dulzor de 300 veces más dulce que la sacarosa. Además, la stevia es considerado un bioedulcorante con importantes propiedades funcionales y bajo en calorías, con efectos beneficiosos para la salud, incluyendo la regulación de los niveles de glucosa en sangre y la reducción de la presión arterial, por lo que se puede evitar enfermedades con la diabetes, la obesidad y el sobrepeso (Putnik et al, 2020).…”

Section: Introductionunclassified

Desarrollo de una bebida nutritiva a partir de lactosuero, zumo de naranja (citrus sinensis) y zanahoria (daucus carota) edulcorada con stevia (stevia rebaudiana b.)

2023

Ñawparisun - RIC

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La presente investigación describe el proceso de desarrollo de una bebida nutritiva a partir de lactosuero, zumos de naranja y zanahoria edulcorada con stevia. Aplicando para el proceso de formulación el Diseño de Box-Behnken. Para el análisis sensorial se realizó a los 03 tratamientos que tuvieron mejores características fisicoquímicas, empleando escala hedónica de 1 a 5 puntos. A la bebida con mayor aceptabilidad se evaluó la vida ito en función al pH, utilizando el método de pruebas acelerada a temperaturas de 4ºC, 20ºC, 30ºC. Se encontró que la adición del porcentaje de lactosuero y zumo de zanahoria no influye significativamente en el pH y °Brix, mientras que el zumo de naranja influye sobre el porcentaje de acidez. El tiempo de vida útil en función al pH fue a 4 ºC (95.58 días), 20 ºC (5.36 días) y 30ºC (52.60 días). La bebida con mayor aceptabilidad sensorial contiene 50% de zumo de naranja, 20% de lactosuero y 7.5% de zumo de zanahoria siendo su composición 0.53% de proteína, 0.02% de grasa, 0.17% de carbohidratos, 0.54% de ceniza y presentó ausencia de Escherichia coli.

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Nano-Stevia reduces the liver injury caused by streptozotocin (STZ)-induced diabetes in rats by targeting PEPCK/GCK genes, INSR pathway and apoptosis

Mousavi-Niri,

Khakpai,

Moheb-Alian

et al. 2023

J Diabetes Metab Disord

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Intra-gastrically administration of Stevia and particularly Nano-Stevia reversed the hyperglycemia, anxiety, and memory impairment in streptozotocin-induced diabetic rats

Cited by 7 publications

References 58 publications

In vitro propagation of Indonesian stevia (Stevia rebaudiana) genotype using axenic nodal segments

In vitro propagation of Indonesian stevia (Stevia rebaudiana) genotype using axenic nodal segments

Desarrollo de una bebida nutritiva a partir de lactosuero, zumo de naranja (citrus sinensis) y zanahoria (daucus carota) edulcorada con stevia (stevia rebaudiana b.)

Nano-Stevia reduces the liver injury caused by streptozotocin (STZ)-induced diabetes in rats by targeting PEPCK/GCK genes, INSR pathway and apoptosis

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