Intra-Golgi transport

Mirоnоv, Alexander A.; Beznoussenko, Galina V.

doi:10.1007/978-3-211-76310-0_21

Cited by 12 publications

(19 citation statements)

References 67 publications

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“…Currently, there are four main models of intracellular transport: (1) the vesicular model (VM); (2) the compartment (cisterna) maturation—progression model (CMPM); (3) the diffusion model (DM; Supplementary Figure S1D); and (4) the kiss-and-run model (KARM), which exists as symmetric and asymmetric variants (Figure 1). These models have been well-described in the past (Rabouille et al, 1995; Bannykh and Balch, 1997; Glick et al, 1997; Mironov et al, 1997, 1998a,b; Pelham and Rothman, 2000; Beznoussenko and Mironov, 2002; Luini et al, 2008; Mironov and Beznoussenko, 2008, 2011, 2012; Glick and Nakano, 2009; Pfeffer, 2010; Glick and Luini, 2011; Mironov, 2014). These models are based on three main principles: dissociation, progression, and diffusion (Figure 2; Supplementary Figures S1A–C, S2).…”

Section: Introductionmentioning

confidence: 92%

“…Megacargoes cannot diffuse along narrow intercisternal connections (Beznoussenko et al, 2014). Also, the concentrating of albumin (Beznoussenko et al, 2014) and large cargo aggregates that cannot diffuse along the intermediate compartment (Claude, 1970; Sabesin and Frase, 1977; Bonfanti et al, 1998; see below) do not support the DM (Mironov and Beznoussenko, 2008, 2012; Mironov et al, 2013).…”

Section: Intra-golgi Transportmentioning

confidence: 99%

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Models of Intracellular Transport: Pros and Cons

Mirоnоv

Beznoussenko

2019

Front. Cell Dev. Biol.

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Intracellular transport is one of the most confusing issues in the field of cell biology. Many different models and their combinations have been proposed to explain the experimental data on intracellular transport. Here, we analyse the data related to the mechanisms of endoplasmic reticulum-to-Golgi and intra-Golgi transport from the point of view of the main models of intracellular transport; namely: the vesicular model, the diffusion model, the compartment maturation–progression model, and the kiss-and-run model. This review initially describes our current understanding of Golgi function, while highlighting the recent progress that has been made. It then continues to discuss the outstanding questions and potential avenues for future research with regard to the models of these transport steps. To compare the power of these models, we have applied the method proposed by K. Popper; namely, the formulation of prohibitive observations according to, and the consecutive evaluation of, previous data, on the basis on the new models. The levels to which the different models can explain the experimental observations are different, and to date, the most powerful has been the kiss-and-run model, whereas the least powerful has been the diffusion model.

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Section: Introductionmentioning

confidence: 92%

Section: Intra-golgi Transportmentioning

confidence: 99%

Models of Intracellular Transport: Pros and Cons

Mirоnоv

Beznoussenko

2019

Front. Cell Dev. Biol.

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“…The demonstration that most cargoes are depleted in COPI vesicles (for example, a 3-fold depletion of biosynthetic transmembrane proteins (type I/II/III) from entering budding COPI vesicles is observed [ 5 , 6 ]; reviewed in details in [ 3 ]) and that cargo aggregates that are incompatible with the size of COPI vesicles are transported through the Golgi apparatus (GA) [ 7 ] has allowed the rejection of the vesicular model. Although Orci et al .…”

Section: Introductionmentioning

confidence: 99%

The Kiss-and-Run Model of Intra-Golgi Transport

Mirоnоv

Beznoussenko

2012

IJMS

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The Golgi apparatus (GA) is the main station along the secretory pathway. Mechanisms of intra-Golgi transport remain unresolved. Three models compete with each other for the right to be defined as the paradigm. The vesicular model cannot explain the following: (1) lipid droplets and aggregates of procollagen that are larger than coatomer I (COPI)-dependent vesicles are transported across the GA; and (2) most anterograde cargoes are depleted in COPI vesicles. The compartment progression/maturation model has the following problems: (1) most Golgi-resident proteins are depleted in COPI vesicles; (2) there are no COPI vesicles for the recycling of the resident proteins in the trans-most-Golgi cisterna; and (3) different proteins have different rates of intra-Golgi transport. The diffusion model based on permanent inter-cisternal connections cannot explain the existence of lipid, ionic and protein gradients across the Golgi stacks. In contrast, the kiss-and-run model has the potential to explain most of the experimental observations. The kiss-and-run model can be symmetric when fusion and then fission occurs in the same place, and asymmetric when fusion takes place in one location, whereas fission takes place in another. The asymmetric kiss-and-run model resembles the carrier maturation mechanism, and it can be used to explain the transport of large cargo aggregates.

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“…Likewise, Mironov et al (2013) compared different models of intra-Golgi transport from the point of view of their ability to explain existing experimental facts. In their view, the kiss-and-run (KAR) model they had proposed in 2008 (Mironov and Beznoussenko 2008) has the highest potential for the explanation of the majority of experimental observations. The review by Machamer (2013) provided a very timely discussion of the transport of large cargo-procollagen and lipoprotein particles or coronaviruses-within the Golgi cisternal stack.…”

Section: The Golgi Apparatusmentioning

confidence: 99%

The Histochem Cell Biol conspectus: the year 2013 in review

Taatjes

Roth

2014

Histochem Cell Biol

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Herein, we provide a brief synopsis of all manuscripts published in Histochem Cell Biol in the year 2013. For ease of reference, we have divided the manuscripts into the following categories: Advances in Methodologies; Molecules in Health and Disease; Organelles, Subcellular Structures and Compartments; Golgi Apparatus; Intermediate Filaments and Cytoskeleton; Connective Tissue and Extracellular Matrix; Autophagy; Stem Cells; Musculoskeletal System; Respiratory and Cardiovascular Systems; Gastrointestinal Tract; Central Nervous System; Peripheral Nervous System; Excretory Glands; Kidney and Urinary Bladder; and Male and Female Reproductive Systems. We hope that the readership will find this annual journal synopsis of value and serve as a quick, categorized reference guide for "state-of-the-art" manuscripts in the areas of histochemistry, immunohistochemistry, and cell biology.

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Intra-Golgi transport

Cited by 12 publications

References 67 publications

Models of Intracellular Transport: Pros and Cons

Models of Intracellular Transport: Pros and Cons

The Kiss-and-Run Model of Intra-Golgi Transport

The Histochem Cell Biol conspectus: the year 2013 in review

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