Intra-individual Open Comparison of Burst-Suppression-Isoflurane-Anaesthesia Versus Electroconvulsive Therapy in the Treatment of Severe Depression

Engelhardt, W.; Carl, G.; Hartung, E.

doi:10.1097/00132586-199312000-00059

Cited by 12 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessments indicated cognitive improvement in the ISO group vs. declines in ECT group after treatment. Subsequent work by Engelhardt [11] demonstrated similar antidepressant effect with a combined series of ISO treatments followed by ECT. A small open-label report by Carl, et al [12] also suggested similar antidepressant efficacy of deep ISO anesthesia compared to ECT.…”

Section: Introductionmentioning

confidence: 83%

Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression

et al. 2013

View full text Add to dashboard Cite

BackgroundMany patients have serious depression that is nonresponsive to medications, but refuse electroconvulsive therapy (ECT). Early research suggested that isoflurane anesthesia may be an effective alternative to ECT. Subsequent studies altered drug, dose or number of treatments, and failed to replicate this success, halting research on isoflurane's antidepressant effects for a decade. Our aim was to re-examine whether isoflurane has antidepressant effects comparable to ECT, with less adverse effects on cognition.MethodPatients with medication-refractory depression received an average of 10 treatments of bifrontal ECT (n = 20) or isoflurane (n = 8) over 3 weeks. Depression severity (Hamilton Rating Scale for Depression-24) and neurocognitive responses (anterograde and retrograde memory, processing speed and verbal fluency) were assessed at Pretreatment, Post all treatments and 4-week Follow-up.ResultsBoth treatments produced significant reductions in depression scores at Post-treatment and 4-week Follow-up; however, ECT had modestly better antidepressant effect at follow-up in severity-matched patients. Immediately Post-treatment, ECT (but not isoflurane) patients showed declines in memory, fluency, and processing speed. At Follow-up, only autobiographical memory remained below Pretreatment level for ECT patients, but isoflurane patients had greater test-retest neurocognitive score improvement.ConclusionsOur data reconfirm that isoflurane has an antidepressant effect approaching ECT with less adverse neurocognitive effects, and reinforce the need for a larger clinical trial.

show abstract

Section: Introductionmentioning

confidence: 83%

Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In this paper we have presented a method which should aid in this kind of long-term treatment. The method is also well applicable in treatment of mental depression by means of BS anesthesia [11]. In the initial evaluation it proved to compare well with segmentation based on visual inspection, however, the tuning and evaluation of the algorithm should continue during its experimental clinical use.…”

Section: Discussionmentioning

confidence: 98%

Adaptive segmentation of burst-suppression pattern in isoflurane and enflurane anesthesia

Lipping

Jäntti

Yli‐Hankala

et al. 1995

J Clin Monitor Comput

View full text Add to dashboard Cite

In this paper a developed novel algorithm for adaptive segmentation of Burst-suppression EEG is presented. The algorithm can detect bursts, suppression and artifacts, dividing the signal into corresponding segments. A compact representation of burst-suppression EEG, useful in monitoring long-term recordings, is presented. In the second part of the paper the burst-suppression patterns of isoflurane and enflurane anesthesia are compared. It is found that bursts as well as suppression segments are shorter in enflurane anesthesia while the coefficient of variability of the segment lengths is similar for the two anesthetics.

show abstract

“…Brief deep isoflurane anesthesia has been shown to produce rapid antidepressant effects in both double-blind and open-label clinical studies [11][12][13][14] . The clinical observations have been, however, partially inconsistent (see 15,16 ), which has reduced the interest to thoroughly evaluate isoflurane as an alternative for ECT and ketamine.…”

Section: Introductionmentioning

confidence: 99%

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila

Ryazantseva

Popova

et al. 2016

Preprint

View full text Add to dashboard Cite

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β).Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus.We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.

show abstract

Intra-individual Open Comparison of Burst-Suppression-Isoflurane-Anaesthesia Versus Electroconvulsive Therapy in the Treatment of Severe Depression

Cited by 12 publications

References 0 publications

Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression

Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression

Adaptive segmentation of burst-suppression pattern in isoflurane and enflurane anesthesia

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Contact Info

Product

Resources

About