Intra/Inter‐Particle Energy Transfer of Luminescence Nanocrystals for Biomedical Applications

Liu, Ching-Ping; Cheng, Shih-Hsun; Chen, Nai-Tzu; Lo, Leu‐Wei

doi:10.1155/2012/706134

Cited by 9 publications

(6 citation statements)

References 75 publications

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“…Interesting probes are based on self-illuminating QDs, using fluorescence resonance energy transfer (FRET) from bioluminescent proteins conjugated to the QD [118,119]. However, potential toxicity due to heavy metal ions has to be taken into account and may be detrimental for their use in clinical bio-imaging [120] and limit their use to in vitro and diagnostic assays.…”

Section: Quantum Dotsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Section: Quantum Dotsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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“…The NIR-emitting QDs comprise II -VI, IV -VI, and III -V compounds, such as CdSe, CdTe, HgTe, PbS, PbSe, PbTe, InAs, InP, and GaAs, as well as alloys of these materials, and core@shell structures, which can allow the emission tuning further and alter the fluorescence lifetimes. Interesting probes are based on self-illuminating QDs, using fluorescence resonance energy transfer (FRET) from bioluminescent proteins conjugated to the QD [118,119] . However, the potential toxicity due to heavy metal ions has to be taken into account and may be detrimental for their use in clinical bioimaging [120] and limit their use to in vitro and diagnostic assays.…”

Section: Quantum Dotsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…For the study of singlet oxygen generating abilities of ClAlTSPc in the presence of UCNPs, the latter were embedded in fiber in order to stabilise the UCNPs luminescence. UCNPs act as nanotransducers, absorbing NIR light and transferring the energy to ClAlTSPc [25] through Förster resonance energy transfer (FRET).…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Behaviour and Singlet Oxygen Production of Aluminium Phthalocyanine in the Presence of Upconversion Nanoparticles

et al. 2015

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NaYF4:Yb/Er/Gd upconversion nanoparticles (UCNP) were synthesised and the photoemission stabilised by embedding them in electrospun fibers. The photophysical behaviour of chloro aluminium tetrasulfo phthalocyanine (ClAlTSPc) was studied in the presence of UCNPs when the two are mixed in solution. The fluorescence quantum yield value of ClAlTSPc decreased in the presence of UCNPs due to the heavy atom effect of UCNPs. This effect also resulted in increase in triplet quantum yields for ClAlTSPc in the presence of UCNPs. The fluorescence lifetimes for UCNPs were shortened at 658 nm in the presence of ClAlTSPc when the former was embedded in fiber and suspended in a dimethyl sulfoxide solution of the latter. A clear singlet oxygen generation by ClAlTSPc though Förster resonance energy transfer was demonstrated using a singlet oxygen quencher, 1,3-diphenylisobenzofuran.

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Intra/Inter‐Particle Energy Transfer of Luminescence Nanocrystals for Biomedical Applications

Cited by 9 publications

References 75 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Fluorescence Behaviour and Singlet Oxygen Production of Aluminium Phthalocyanine in the Presence of Upconversion Nanoparticles

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