Intra-lesional amphotericin B—Worth a try, maybe for lots of things, but we need more data!

Malík, Richard; Krockenberger, M. B.; O'Brien, Carolyn

doi:10.1016/j.jfms.2009.02.007

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Feline sino-orbital fungal infections may eventually benefit from this intra-lesional orbital approach, although, due to the limited retrobulbar space and proximity of the meninges and optic nerve, care should be taken in order to avoid toxicity and iatrogenic damage. 67 In the present case, systemic amphotericin B administration was chosen as the last option, due to high MIC values. However, it should be emphasised that favourable MIC values have been shown to be poorly predictive of the in vivo response for itraconazole and posaconazole, which were used in this case.…”

Section: Treatment Optionsmentioning

confidence: 97%

Invasive Mould Infections of the Naso-Orbital Region of Cats: A Case InvolvingAspergillus Fumigatusand an Aetiological Review

Giordano¹,

Gianella

Bò³

et al. 2010

Journal of Feline Medicine and Surgery

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Section: Treatment Optionsmentioning

confidence: 97%

Invasive Mould Infections of the Naso-Orbital Region of Cats: A Case InvolvingAspergillus Fumigatusand an Aetiological Review

Giordano¹,

Gianella

Bò³

et al. 2010

Journal of Feline Medicine and Surgery

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“…Proposed benefits of local therapy include increased drug concentration at the site of infection and decreased systemic side effects of the drug 19. Guidelines for intralesional AMB treatment are lacking 23. Injections in our patient were well tolerated and no adverse systemic side effects were noted.…”

Section: Discussionmentioning

confidence: 73%

Treatment of abdominal granuloma and hypercalcaemia caused byCladophialophora bantianawith combination antifungal chemotherapy and hyperbaric oxygen therapy in a dog

Lester

Walton

Grosso

et al. 2020

Vet Record Case Reports

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A 5-year-old intact male Boxer was evaluated for a 4-month history of ventral abdominal mass with fistulous tracts. Thoracic and abdominal CT revealed a large soft-tissue mass in the rectus abdominis muscle extending into the peritoneal cavity. Cytologic and histologic findings were consistent with an intra-abdominal fungal granuloma with pigmented fungal hyphae suggestive of phaeohyphomycosis. PCR of the isolated fungal organism confirmed Cladophialophora bantiana as the aetiologic agent. Initial therapy consisted of oral terbutaline and itraconazole and weekly to biweekly hyperbaric oxygen therapy. Intralesional amphotericin B was initiated following diagnosis. Therapy was associated with transient draining tract resolution though the mass remained overall static in size. Hypercalcaemia with associated increased serum calcitriol developed with progressive disease, which resolved in response to low-dose steroid therapy and a calcium-restricted and vitamin D-restricted diet. The dog was euthanised 13 months after initial presentation following the development of acute weakness, fever and dyspnoea.

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“…In human cases of phaeohyphomycosis due to dematiaceous fungi with chromoblastomycosis and extensive lesions or poor response to itraconazole, combined treatment with 5-fluorocytosine or terbinafine is usually prescribed. 22 Another possible therapeutic option for phaeohyphomycosis in cats would be the use of intralesional amphoterecin B, as reported in the literature for the treatment of other skin and subcutaneous mycoses, 23 such as sporotrichosis, 24 , 25 especially in refractory cases, in combination with azoles. 24 , 25 Strategies with other azoles, other than itraconazole or posaconazole, have also been used.…”

Section: Discussionmentioning

confidence: 99%

First report of phaeohyphomycosis caused by Phialophora americana in a domestic cat from Argentina

Borrás¹,

Messina

Abrantes

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old male neutered domestic shorthair cat from Quilmes (Province of Buenos Aires, Argentina) presented at the Infectious Diseases and Parasitology Unit with a hyperpigmented nodule of 5 cm diameter on the nasal plane with a small ulceration of more than 1 year’s evolution. A scaly and hyperpigmented alopecic lesion of 3 cm in diameter was found on the lower edge of the tail. The patient was under immunosuppressive therapy with corticosteroids for lymphoplasmacytic duodenitis. Samples of the lesion present on the nasal plane were taken under a surgical procedure. In the wet mount preparations, pigmented irregular hyphae were observed. They developed dark colonies when cultured on Sabouraud medium. On micromorphology, structures compatible with Phialophora species were identified. PCR and sequencing of ITS (ITS1-5.8S-ITS2) confirmed Phialophora americana as the etiologic agent. A therapeutic scheme that included a combination of itraconazole oral solution (1.5 mg/kg PO q12h) with terbinafine (30 mg/kg PO q24h) was indicated for a period of 10 months. The patient died of complications resulting from its underlying disease. Relevance and novel information As far as the authors are aware, this is the first study to report P americana as an etiologic agent of phaeohyphomycosis in cats. In this case study, the species was identified using molecular tests.

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Intra-lesional amphotericin B—Worth a try, maybe for lots of things, but we need more data!

Cited by 9 publications

References 12 publications

Invasive Mould Infections of the Naso-Orbital Region of Cats: A Case InvolvingAspergillus Fumigatusand an Aetiological Review

Invasive Mould Infections of the Naso-Orbital Region of Cats: A Case InvolvingAspergillus Fumigatusand an Aetiological Review

Treatment of abdominal granuloma and hypercalcaemia caused byCladophialophora bantianawith combination antifungal chemotherapy and hyperbaric oxygen therapy in a dog

First report of phaeohyphomycosis caused by Phialophora americana in a domestic cat from Argentina

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