Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Puppels, Gerwin J.; Barroso, Elisa M.; Aaboubout, Yassine; Soares, Maria R Nunes; Artyushenko, Viacheslav; Bocharnikov, Alexey; Usenov, Iskander; Schut, Tom C. Bakker; Jong, Robert J. Baatenburg de; Wolvius, Eppo B.; Hove, Ivo ten; Mast, Hetty; Hardillo, José A.; Sewnaik, Aniel; Meeuwis, Cees A.; Lanschot, F. Van; Monserez, Dominiek; Keereweer, Stijn; Wolf, Martin van der; Sokolova, Elena A.; Koljenović, Senada

doi:10.1117/12.2544394

Cited by 3 publications

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“…An example of such technology is Raman spectroscopy; an optical technique which has been shown to discriminate between OCSCC and surrounding healthy tissue with high sensitivity and specificity (soft and bone tissue) (41)(42)(43). A dedicated instrument employing a fiber optic needle probe for rapid assessment of resection margins on OCSCC specimen is currently under development (44).…”

Section: Discussionmentioning

confidence: 99%

Performance of Intraoperative Assessment of Resection Margins in Oral Cancer Surgery: A Review of Literature

et al. 2021

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IntroductionAchieving adequate resection margins during oral cancer surgery is important to improve patient prognosis. Surgeons have the delicate task of achieving an adequate resection and safeguarding satisfactory remaining function and acceptable physical appearance, while relying on visual inspection, palpation, and preoperative imaging. Intraoperative assessment of resection margins (IOARM) is a multidisciplinary effort, which can guide towards adequate resections. Different forms of IOARM are currently used, but it is unknown how accurate these methods are in predicting margin status. Therefore, this review aims to investigate: 1) the IOARM methods currently used during oral cancer surgery, 2) their performance, and 3) their clinical relevance.MethodsA literature search was performed in the following databases: Embase, Medline, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar (from inception to January 23, 2020). IOARM performance was assessed in terms of accuracy, sensitivity, and specificity in predicting margin status, and the reduction of inadequate margins. Clinical relevance (i.e., overall survival, local recurrence, regional recurrence, local recurrence-free survival, disease-specific survival, adjuvant therapy) was recorded if available.ResultsEighteen studies were included in the review, of which 10 for soft tissue and 8 for bone. For soft tissue, defect-driven IOARM-studies showed the average accuracy, sensitivity, and specificity of 90.9%, 47.6%, and 84.4%, and specimen-driven IOARM-studies showed, 91.5%, 68.4%, and 96.7%, respectively. For bone, specimen-driven IOARM-studies performed better than defect-driven, with an average accuracy, sensitivity, and specificity of 96.6%, 81.8%, and 98%, respectively. For both, soft tissue and bone, IOARM positively impacts patient outcome.ConclusionIOARM improves margin-status, especially the specimen-driven IOARM has higher performance compared to defect-driven IOARM. However, this conclusion is limited by the low number of studies reporting performance results for defect-driven IOARM. The current methods suffer from inherent disadvantages, namely their subjective character and the fact that only a small part of the resection surface can be assessed in a short time span, causing sampling errors. Therefore, a solution should be sought in the field of objective techniques that can rapidly assess the whole resection surface.

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Section: Discussionmentioning

confidence: 99%

Performance of Intraoperative Assessment of Resection Margins in Oral Cancer Surgery: A Review of Literature

et al. 2021

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“…These techniques are less influenced by inflammatory processes, and some of them can also be used to assess bony structures, adding to their versatility and utility [ 33 ]. These controversies have led to the investigation of optical and spectroscopic methods and their utilization as a surgical device for intraoperative use [ 46 , 47 , 48 ] ( Table 3 ). Spectroscopy, a form of narrow-field analysis, may play a significant role in the intraoperative assessment of resection margins in oral cancer.…”

Section: Spectroscopy For the Intraoperative Assessment Of The Resect...mentioning

confidence: 99%

Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy

Vlocskó,

Piffkó,

Janovszky

2023

Cancers

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In parallel with the increasing number of oncological cases, the need for faster and more efficient diagnostic tools has also appeared. Different diagnostic approaches are available, such as radiological imaging or histological staining methods, but these do not provide adequate information regarding the resection margin, intraoperatively, or are time consuming. The purpose of this review is to summarize the current knowledge on spectrometric diagnostic modalities suitable for intraoperative use, with an emphasis on their relevance in the management of oral cancer. The literature agrees on the sensitivity, specificity, and accuracy of spectrometric diagnostic modalities, but further long-term prospective, multicentric clinical studies are needed, which may standardize the intraoperative assessment of the resection margin and the use of real-time spectroscopic approaches.

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Light guidance up to 6.5 µm in borosilicate soft glass hollow-core microstructured optical waveguides

et al. 2020

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Limited operating bandwidth originated from strong absorption of glass materials in the infrared (IR) spectral region has hindered the potential applications of microstructured optical waveguide (MOW)-based sensors. Here, we demonstrate multimode waveguide regime up to 6.5 µm for the hollow-core (HC) MOWs drawn from borosilicate soft glass. Effective light guidance in central HC (diameter ∼240 µm) was observed from 0.4 to 6.5 µm despite high waveguide losses (0.4 and 1 dB/cm in near- and mid-IR, respectively). Additional optimization of the waveguide structure can potentially extend its operating range and decrease transmission losses, offering an attractive alternative to tellurite and chalcogenide-based fibers. Featuring the transparency in mid-IR, HC MOWs are promising candidates for the creation of MOW-based sensors for chemical and biomedical applications.

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Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Cited by 3 publications

References 0 publications

Performance of Intraoperative Assessment of Resection Margins in Oral Cancer Surgery: A Review of Literature

Performance of Intraoperative Assessment of Resection Margins in Oral Cancer Surgery: A Review of Literature

Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy

Light guidance up to 6.5 µm in borosilicate soft glass hollow-core microstructured optical waveguides

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