“…Other factors include medications that cause hyperkalemia (angiotensinconverting enzyme inhibitors, angiotensin II receptor blockers, aldosterone antagonists, potassium-sparing diuretics, potassium supplements, alpha-adrenergic agents, beta-blockers, nonsteroidal anti-inflammatory drugs, digoxin, trimethoprim, and heparin), red blood cell transfusion, liver surgery (transplant, lobectomy, prolonged ischemia, and reperfusion), major vascular surgery, organ/limb ischemia-reperfusion, extensive muscle dissection, tumor lysis syndrome, low cardiac output state, metabolic acidosis, hypothermia, hypocalcemia, hyperglycemia, low insulin levels, and so on. 1,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Mannitol as used for neurosurgery can cause severe hyperkalemia and cardiac arrest in otherwise healthy patients. Several cases have been reported in the literature usually presenting after 20-60 minutes of its administration and appear to be infusion rate related.…”