Intra-osseous neurilemoma. Case report and review of thirty-one cases from the literature

Wirth, W; Bray, CB

doi:10.2106/00004623-197759020-00021

Cited by 36 publications

(19 citation statements)

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“…This tumour is usually found in lower extremities and retroperitonium and is rare in head and neck area [4][5][6][7][8][9]. The intraosseous localization of MPNST is very rare in literature [10]: Dahlin and Krishanan [11] reported 10 cases, Wirth and Bray [12] 31 cases, Bullock et al [13] 18 cases, and De la Monte et al [14] presented 60 histologically documented cases. The diagnosis of MPNST has also been complicated by unclear criteria for determining the malignancy of a tumour originating in the nerve [15].…”

Section: Introductionmentioning

confidence: 99%

Malignant peripheral nerve cell tumour

Sham¹,

Ghorpade²,

Shetty³

et al. 2010

J. Maxillofac. Oral Surg.

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Malignant Peripheral Nerve Sheath Tumour (MPNST) also termed as spindle cell malignancy of the peripheral nerve schwann cell or neurogenic sarcoma represents 10% of all soft tissue sarcomas. The tumour is usually found in lower extremities and only 10% to 20% of all lesions occur in head and neck region thus making it a rare entity. Central involvement, particularly in the jaw bones is quite unusual. Neurofibroma is one of the common nerve sheath tumours occurring in the soft tissues and generally appears in neurofibromatosis I (NF-I or von recklinghausen's disease). MPNST are uncommon sarcomas that almost always arise in the soft tissues. Here we report a case of intraosseous peripheral nerve sheath tumour occurring in the mandible and discuss the surgical management with adjuvant and neoadjuvant treatment plan.

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Section: Introductionmentioning

confidence: 99%

Malignant peripheral nerve cell tumour

Sham¹,

Ghorpade²,

Shetty³

et al. 2010

J. Maxillofac. Oral Surg.

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“…S chwannomas are benign neoplasms arising from the myelinating Schwann cells of the nerves; they are the most common tumors of the peripheral nerves. [1][2][3][4] Intraosseous schwannoma is a rare entity. Approximately 200 cases are described in the world literature, mostly involving the mandible.…”

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confidence: 99%

Giant Intraosseous Schwannoma of the Ileopubic Ramus

Benazzo¹,

Marullo²,

Rossi³

et al. 2013

Orthopedics

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Schwannomas are the most common tumors of the peripheral nerves. Intraosseous schwannoma is a rare entity; approximately 200 cases are described in the world literature, with only 1 involving the ileopubic ramus. To the authors' knowledge, this article is the first to describe a giant intraosseous schwannoma of the ileopubic ramus, its clinical presentation and radiographic aspect, its histological findings, its biological behavior, and the differential diagnosis. It is also the first to describe surgical treatment of this entity. A 63-year-old woman presented with paroxysmal pain at the right groin. Radiographs showed a multilocular lytic lesion of the right ileopubic ramus, extending from the acetabulum to the pubic symphysis. Magnetic resonance imaging revealed extraosseous extension in the pelvis and in the anteromedial region of the right thigh. An incisional biopsy revealed fibroconnective tissue with sparse spindle cells in a myxoid stroma; diffuse expression of S100 protein was observed by immunohistochemistry. Intraosseous neurofibroma was the first histopathologic diagnosis. The 12×8×4-cm lesion was entirely removed via a Letournel ileoinguinal approach. Reconstruction of the ileopubic ramus was performed with an autologous bone graft taken from the omolateral iliac crest and fixed by a pelvic reconstruction plate. Histopathological examination revealed Antoni A and B patterns with Verocay bodies, no mitosis or cellular atypia, and diffuse expression of S100 protein by immunohistochemistry, all features indicative of a benign schwannoma. The patient returned to activities of daily living with no limitations. No recurrence had occurred 24 months postoperatively.

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“…The mandible, maxilla and sacrum are the most common sites of intraosseous schwannoma involvement (2,11). Of a total of 165 cases in five previous review studies, 81 cases (49%) affected the mandible, 12 (7%) the maxilla, 10 (6%) the sacrum, 40 (24%) the long bones, 6 (4%) the vertebra, 5 (3%) the rib, 4 (2%) the patella, 3 (2%) the pelvis, 2 (1%) the scapula and 2 (1%) affected other bones (3,4,(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 2 cases of intraosseous schwannoma of the humerus were reported to arise in the distal metaphysis. One case was in the medial epicondyle and one was in the lateral epicondyle (8,10). Although 8 cases of intraosseous schwannoma involving the ulna have been observed in a large series of reviews (4,6,7), their detailed locations in the ulnar bone were unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrence is rare, but may be associated with incomplete resection (10 Therefore, in the current case report a case of intraosseous schwannoma arising in the ulna is presented. A benign bone tumor was suspected from plain radiographs and MRI, and intraosseous schwannoma was diagnosed based on the pathological findings of the surgically resected tumor.…”

Section: Introductionmentioning

confidence: 92%

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Association between intraosseous schwannoma occurrence and the position of the intraosseous nutrient vessel: A case report

et al. 2016

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Abstract. Intraosseous schwannoma is a rare benign bone tumor that originates from Schwann cells of the nerve sheath. The majority of intraosseous schwannomas arise in the mandible and sacrum, but an intraosseous schwannoma involving the ulna is described in the present case report. Radiologically, the current case presented as a well-defined lytic lesion, with a pathological fracture and no intralesional calcification, in the proximal metaphysis of the left ulna. Using magnetic resonance imaging, an intraosseous mass spreading out from the cortical defect was observed. The lesion appeared isointense to skeletal muscle on T1-weighted images, and hyperintense or heterogeneous on T2-weighted images. The differential diagnosis comprised benign bone tumors, including bone cyst, aneurysmal bone cyst, giant cell tumor and fibrous dysplasia. Based on the results of a needle biopsy, a schwannoma involving the ulnar bone was diagnosed, and tumor marginal resection followed by artificial bone grafting and fixation was performed. A total of one year subsequent to surgery, the patient exhibits no symptoms, and there is no evidence of disease recurrence.

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Intra-osseous neurilemoma. Case report and review of thirty-one cases from the literature

Cited by 36 publications

References 0 publications

Malignant peripheral nerve cell tumour

Malignant peripheral nerve cell tumour

Giant Intraosseous Schwannoma of the Ileopubic Ramus

Association between intraosseous schwannoma occurrence and the position of the intraosseous nutrient vessel: A case report

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