Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice

Qiao, Songlin; Alasmi, Samer; Wyatt, Amanda; Wartenberg, Philipp; Wang, Hongmei; Candlish, Michael; Das, Debajyoti; Aoki, Mari; Grünewald, Ramona; Zhou, Zongqing; Tian, Qi; Yu, Qiang; Götz, Viktoria; Belkacemi, Anouar; Raza, Ahsan; Ectors, Fabien; Kattler, Kathrin; Gasparoni, Gilles; Walter, Jörn; Lipp, Peter; Mollard, Patrice; Bernard, Daniel J.; Karataylı, Ersin; Karataylı, Senem Ceren; Lammert, Frank; Boehm, Ulrich

doi:10.1038/s41467-023-36681-z

Cited by 12 publications

(4 citation statements)

References 62 publications

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“…The FSHβ protein can freely diffuse into prokaryotic cells after its expression. In the prediction of subcellular localization, our results indicated that FSHβ protein was also expressed in the nucleus (Liu et al 2020;Tian et al 2023). In addition, further prediction using TMHMM confirmed that there was no obvious transmembrane domain and signal peptide distribution in the FSHβ protein (Palmerini et al 2016;Niu et al 2019).…”

Section: Discussionmentioning

confidence: 63%

Analysis and Importance of FSH? Gene in Pig Reproductive Performance

2023

Int J Vet Sci

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FSHβ plays an important role in the reproductive performance of pigs, but there are no studies on its protein structure and function. In this study, bioinformatics tools were used to predict the physicochemical properties, secondary and tertiary structure, hydrophobicity/hydrophilicity, transmembrane domain, and sites of phosphorylation and glycosylation of signal peptide FSHβ protein of sows. The results showed that the number of amino acids of FSHβ was 185, that is, the theoretical isoelectric amino acid point was 53.8, the instability index was 46.23, and the average hydrophilicity coefficient was 0.732. FSHβ protein was found to be a hydrophobic protein without a transmembrane domain, with 33 phosphorylation sites. None of the signal peptides was found to be distributed in the inner complete sequence. The secondary structure was mainly composed of α-helix, extended strand, β-turn, and random coil, with values of 29.97, 27.53, 10.10 and 32.40%, respectively. In summary, this study suggests that the amino acid sequence (988~1146aa) of FSHβ can be used to express antigens. It provides a reliable basis for further study of FSHβ protein function, purification of FSHβ protein, preparation of FSHβ antibody, and drug screening to improve reproductive performance of pigs.

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Section: Discussionmentioning

confidence: 63%

Analysis and Importance of FSH? Gene in Pig Reproductive Performance

2023

Int J Vet Sci

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“…The explanation given here is similar to that of the pancreas: the structure and function of endocrine cells in the same gland affect the function of other endocrine cells. 40 In addition, the effects of FSH on hepatic lipid metabolism show gender dimorphism, and this study failed to detect FSHR in the pituitary gland of male mice, explaining why FSH does not regulate hepatic steatosis in male mice. In conclusion, FSH may affect lipid metabolism through paracrine effects outside the HPG axis, making it difficult to define the therapeutic value of FSH agonists or inhibitors for metabolic syndrome.…”

Section: Hpg Axis and Hepatic Lipid Homeostasismentioning

confidence: 67%

Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver Disease-A Concept Worth Revisiting

Li,

Zheng,

Limbara

et al. 2024

J Clin Transl Hepatol

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Hepatic lipid homeostasis is not only essential for maintaining normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver. The controversy over the nomenclature of non-alcoholic fatty liver disease (NAFLD) in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic metabolism. Pituitary-targeted gland axes (PTGA), an important hormone-regulating system, are indispensable in lipid homeostasis. This review focuses on the roles of thyroid hormones, adrenal hormones, sex hormones, and their receptors in hepatic lipid homeostasis, and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid metabolism. It also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease (EAFLD) and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.

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“…A recent study has revealed a third possible mechanism by which FSH affects liver lipid metabolism. This study revealed that the paracrine action of FSH on pituitary corticotropes can serve as a mechanism to inhibit the synthesis of corticosterone and protect against hepatic steatosis [ 38 ]. The fourth possible reason may be associated with inhibin A.…”

Section: Discussionmentioning

confidence: 99%

Follicle-stimulating hormone is negatively associated with nonalcoholic fatty liver disease in a Chinese elderly population: a retrospective observational study

Li,

Xin,

Guo

et al. 2023

BMC Endocr Disord

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Background Several studies have explored the connection between follicle-stimulating hormone (FSH) and nonalcoholic fatty liver disease (NAFLD). However, the impact of FSH elevation on NAFLD remains a topic of debate. Hence, this investigation aimed to evaluate the potential correlation between FSH levels and NAFLD in the aging population. Methods This was a retrospective observational cross-sectional study between July 2017 and August 2018 in our hospital. We used data obtained from 455 patients over 60 years old. Anthropometrics and laboratory tests were performed for each patient. NAFLD was diagnosed by sonographic features and the fatty liver index (LFI). Results Of the 455 patients, 200 (43.96%) had NAFLD on their ultrasound and 169 (37.14%) had NAFLD according to the LFI. An intraclass correlation coefficient of the two methods was 80.4% (P < 0.001). People with NAFLD on their ultrasound showed lower FSH levels (52.68 vs. 61.39 IU/L) and more unfavorable metabolic profiles. FSH was negatively correlated with age, alanine aminotransferase, estradiol, testosterone, systolic blood pressure, waist, body mass index, fasting blood glucose, postload plasma glucose and positive associated with total cholesterol, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol by Spearman correlation analysis (all P < 0.05). By controlling for all confounding factors, the odds ratios (OR) of FSH for NAFLD were determined in elderly individuals, both men and women, aged 60–70 years and over 70 years. These ORs were found to be 0.937, 0.982, 0.983, and 0.973, respectively, with corresponding 95% confidence intervals (CI) of 0.892–0.984 (P = 0.009), 0.971–0.993 (P = 0.002), 0.967–0.999 (P = 0.033), and 0.958–0.989 (P = 0.001). In addition, our findings demonstrated no significant correlation between FSH and advanced fibrosis when adjusting for potential covariates. The OR for advanced fibrosis was 0.979 (95% CI, 0.938–1.022, P = 0.339). Additionally, ROC curve analysis showed an optimal cut-off value of 66.91 for women and 15.25 for men for NAFLD diagnosis. Conclusions There was an inverse relationship observed between levels of FSH in the blood serum and NAFLD in the elderly population. These findings suggest that reduced FSH levels might serve as a potential risk factor or biomarker for NAFLD in the elderly.

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Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice

Cited by 12 publications

References 62 publications

Analysis and Importance of FSH? Gene in Pig Reproductive Performance

Analysis and Importance of FSH? Gene in Pig Reproductive Performance

Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver Disease-A Concept Worth Revisiting

Follicle-stimulating hormone is negatively associated with nonalcoholic fatty liver disease in a Chinese elderly population: a retrospective observational study

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