2023
DOI: 10.1038/s41594-023-01156-8
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Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism

Joseph W. Wragg,
Paige-Louise White,
Yavor Hadzhiev
et al.

Abstract: Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, little is known about the role of the core promoter in defining transcript identity and post-transcriptional fates, a potentially crucial layer of transcriptional regulation in cancer. In this study, we use CAGE-seq analysis to uncover widespread use of dual-initiation promoters in which non-canonical, first-base-cytosine (C) transcription initiation occurs alongside first-base-purine initiation… Show more

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