Climate change has a strong impact on inland water bodies such as lakes. This means that the increase in lake temperature recorded in recent decades-in Europe as well-can change the evaporation regime of the lakes. This, together with the variation of the water cycle, in particular precipitation, implies that the water mass balance of lakes may vary due to climate change. Water mass balance modeling is therefore of paramount importance to monitor lakes in the context of global warming. Although many studies have focused on such a modeling, there is no shared approach that can be used for any lake across the globe, irrespective of the size. This becomes even more problematic for shallow and small lakes, for which few studies exist. For this reason, in this paper the use of reanalysis data, in particular ERA5-Land provided by the European Centre for Medium-Range Weather Forecasts (ECMWF), is proposed for the mass balance modeling. In fact, ERA5-Land has a global coverage and it is the only data source comprising a specific model for lakes, the Fresh-water Lake model (FLake). The chosen case study is the Trasimeno lake, a small and shallow lake located in Central Italy. The use of the reanalysis was preceded by data validation by considering both ground-based and satellite observations. The results show that there is a good agreement between the observed monthly variation of the lake level, ΔH, and the corresponding values of the water storage, δ, computed by means of the ERA5-Land data (Pearson coefficient larger than 70%). Discrepancies between observations and the ERA5-Land data happen in periods characterized in Europe by an extreme climate anomaly. This promising result encourages the use of ERA5-Land for other lakes.