Intra tester reliability of sympathetic skin responses in subjects with primary palmar hyperhidrosis

Ghandali, Elham; Hosseini, Seyed Majid; Moghimi, Hamid; Kalantari, Khosro Khademi; Moghadam, Saeed Talebian; Baghban, Alireza Akbarzadeh; Mortazavi, Seyedeh Maryam

doi:10.1016/j.jbmt.2020.02.024

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Of the remaining 10 patients, 4 reported a slight reduction in sweating. The mean EDAcw intensity and the EDAcw per area in this group showed no statistically significant difference between the three observation times [χ2(2) 2.000; p = 0.37], as shown in Figure 5.…”

Section: Resultsmentioning

confidence: 85%

“…The intensity of EDAcw in the hands, as measured by area, is described in Table 1 and illustrated in Figure 2. A statistically significant difference was observed among the three observation times [χ2(2) 28.444; p < 0.001]. When comparing each time point, differences were found between the preoperative period and the 1st PO day (p < 0.001), between the preoperative period and the 30th PO day (p = 0.01), and between the 1st PO day and the 30th PO day (p = 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…The average intensity of EDAcw in the feet of the 18 patients who had surgery showed a statistically significant difference between two of the three observation times [χ2(2) 10.941; p < 0.01], which were between the preoperative period and the 1st PO day (p < 0.01) and between the preoperative period and the 30th PO day (p = 0.02). However, no significant difference was noted between the 1st PO and the 30th PO (p = 0.61).…”

Section: Resultsmentioning

confidence: 99%

“…Primary hyperhidrosis (HH) is characterized by excessive sweating unrelated to external triggers or body temperature regulation (1). It is often associated with dysfunction of the sympathetic nervous system (SNS) (2). This condition most commonly affects the palms of the hands, soles of the feet and axilla, but can also be present on the face, trunk, and other parts of the body.…”

Section: Introductionmentioning

confidence: 99%

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The Use of an Objective Method (Continuous Exosomatic Electrodermal Activity Without External Stimuli) to Evaluate Patients With Hyperhidrosis Undergoing Video-Assisted Sympathectomy

Silveira,

Sorbello,

Wolosker

et al. 2024

Preprint

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2.ABSTRACTObjectiveTo objectively assess continuous exosomatic electrodermal activity without external stimuli in primary hyperhidrosis patients, before and after sympathectomy and compare it with responses to clinical investigation questionnaires.MethodIn a prospective study, 28 participants were divided into two groups. The first group consisted of 18 patients with palmoplantar hyperhidrosis who underwent sympathectomy on the fourth and fifth costal arches, bilaterally and sequentially. The second group, serving as a control, consisted of 10 patients. The assessment involved 2 self-explanatory questionnaires; the control group completed the questionnaires once, while the sympathectomy group completed them before surgery, one day and 30 days later. Sweating was objectively evaluated by measuring electrodermal activity (EDA) using the MP36R biosensor from Biopac Systems Inc. USA. This was done by carrying out measurements before surgery, on the first postoperative and on the thirtieth postoperative using an exosomatic technique and a constant electrical flow. Measurements were taken sequentially from the hands and feet, for 5 uninterrupted minutes at each site, after 10 minutes of rest, in a comfortable sitting position, without external stimuli, and in an air-conditioned environment. The study also collected anthropometric, clinical, and surgical data, and no significant sociodemographic differences were observed between the groups.ResultsIn the group that underwent thoracic sympathectomy, there was a significant improvement in quality of life and a reduction in palmar and plantar sweating, as assessed by the questionnaires. Electrodermal activity showed significantly higher levels in the hands and feet of patients with hyperhidrosis compared to the control group during the preoperative assessment. After surgery, there was a reduction in electrodermal activity in the hands, and 100% of the sample analyzed showed a decrease in sweating. As for the evaluation of the feet, 67% of the patients reported a reduction in sweating, and 44% showed a statistically significant decline in EDA.ConclusionContinuous exosomatic electrodermal activity without external stimuli is a suitable method for assessing patients with palmoplantar hyperhidrosis, with appropriate clinical correlation compared to the questionnaire’s answers quantifying sweating and quality of life.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Use of an Objective Method (Continuous Exosomatic Electrodermal Activity Without External Stimuli) to Evaluate Patients With Hyperhidrosis Undergoing Video-Assisted Sympathectomy

Silveira,

Sorbello,

Wolosker

et al. 2024

Preprint

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“…Iontophoresis is a physical technique in which a physiologically acceptable electrical current is used to transport molecules across the skin [45]. The mechanisms of electrorepulsion (driving charged molecules across the skin) and electroosmosis (producing a bulk fluid stream in the membrane which carries charged and uncharged molecules) lead to the iontophoretic process being useful for both charged and uncharged molecules [46,47].…”

Section: Iontophoresismentioning

confidence: 99%

Skin permeability, a dismissed necessity for anti‐wrinkle peptide performance

Mortazavi

Moghimi

2022

Intern J of Cosmetic Sci

Self Cite

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Background:The skin offers various benefits and potential for peptide delivery if its barrier performance can be reduced temporarily and reversibly. As peptides possess high molecular weight, hydrophilic nature (in most cases), and ionizable groups in the structure, their skin delivery is highly challenging. Apart from this, they are susceptible to the proteolytic enzymes in the skin. Anti-wrinkle peptides, like other peptides, suffer from insufficient skin permeability, while most of them must penetrate deep in the skin to present their efficacy. Although the cellular studies indicate the effectiveness of such peptides, without the ability to permeate the skin sufficiently, this efficacy is useless. Poor skin permeability of anti-wrinkle peptides has led to ongoing research for finding feasible and noninvasive enhancement methods that would be desirable for consumers of cosmetic products. Method:In this paper, the possibility of skin permeation of anti-wrinkle peptides as well as the chemical, physical, and encapsulation approaches that have been employed to date to increase permeability of these difficult molecules are thoroughly reviewed.Results: Most anti-wrinkle peptides are not appropriate candidates for skin permeation and the use of enhancement methods is essential to increase their permeability. To do so, only some permeability enhancement approaches have been applied so far, including chemical modification with hydrophobic moieties or cell penetrating peptides, metal complexation, chemical permeation enhancers, iontophoresis, microneedles, and encapsulation in nanocarriers. The results of studies published on the skin permeability of anti-wrinkle peptides carnosine, GHK, PKEK, GEKG, GQPR, and KTTKS indicate that the skin permeability of these peptides can be successfully increased. Conclusion:Although the skin permeability of most anti-wrinkle peptides is not high enough and most anti-wrinkle peptides might not reach their targets in the skin at right concentrations, their permeability can be increased to therapeutic concentrations using various enhancement approaches. K E Y W O R D Santi-wrinkle peptides, cosmetic peptides, permeability enhancement approaches, skin delivery of peptides, skin permeability | 233 MORTAZAVI and MOGHIMI Résumé Contexte: La peau offre divers avantages et a la faculté de recevoir des peptides si l'on parvient à réduire temporairement et de manière réversible sa capacité à fonctionner comme une barrière. Comme les peptides ont un poids moléculaire élevé, une nature hydrophile (dans la plupart des cas) et possèdent des groupes ionisables dans leur structure, il est très difficile d'en faire bénéficier la peau. En outre, ils sont sensibles aux enzymes protéolytiques de la peau. Les peptides antirides, comme d'autres peptides, souffrent d'une capacité insuffisante de perméation de la peau ; or, la plupart d'entre eux doivent y pénétrer profondément pour avoir une efficacité.Bien que les études cellulaires indiquent l'efficacité de ces peptides, s'ils sont incapables de pénétrer s...

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Triboelectric Nanogenerators for Therapeutic Electrical Stimulation

et al. 2021

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Current solutions developed for the purpose of in and on body (IOB) electrical stimulation (ES) lack autonomous qualities necessary for comfortable, practical, and self‐dependent use. Consequently, recent focus has been placed on developing self‐powered IOB therapeutic devices capable of generating therapeutic ES for human use. With the recent invention of the triboelectric nanogenerator (TENG), harnessing passive human biomechanical energy to develop self‐powered systems has allowed for the introduction of novel therapeutic ES solutions. TENGs are especially effective at providing ES for IOB therapeutic systems given their bioconformability, low cost, simple manufacturability, and self‐powering capabilities. Due to the key role of naturally induced electrical signals in many physiological functions, TENG‐induced ES holds promise to provide a novel paradigm in therapeutic interventions. The aim here is to detail research on IOB TENG devices applied for ES‐based therapy in the fields of regenerative medicine, neurology, rehabilitation, and pharmaceutical engineering. Furthermore, considering TENG‐produced ES can be measured for sensing applications, this technology is paving the way to provide a fully autonomous personalized healthcare system, capable of IOB energy generation, sensing, and therapeutic intervention. Considering these grounds, it seems highly relevant to review TENG‐ES research and applications, as they could constitute the foundation and future of personalized healthcare.

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Intra tester reliability of sympathetic skin responses in subjects with primary palmar hyperhidrosis

Cited by 5 publications

References 28 publications

The Use of an Objective Method (Continuous Exosomatic Electrodermal Activity Without External Stimuli) to Evaluate Patients With Hyperhidrosis Undergoing Video-Assisted Sympathectomy

The Use of an Objective Method (Continuous Exosomatic Electrodermal Activity Without External Stimuli) to Evaluate Patients With Hyperhidrosis Undergoing Video-Assisted Sympathectomy

Skin permeability, a dismissed necessity for anti‐wrinkle peptide performance

Triboelectric Nanogenerators for Therapeutic Electrical Stimulation

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