Intra-uterine insemination versus timed intercourse for cervical hostility in subfertile couples

Helmerhorst, FM; Gornas, ADH; Finken, MJJ; Da, Grimes

doi:10.1002/14651858.cd002809

Cited by 8 publications

(12 citation statements)

References 9 publications

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“…The largest study analyzed 156 cycles, but in 80% of the IUI cycles, as well as in the cycles in which intercourse was advised, ovarian hyperstimulation was given (10). Pooling of the data from these trials could provide a better estimate, but this is not possible because of the quality of the trials and heterogeneity in the participant characteristics and interventions (13). In view of these issues, we assessed the effectiveness of IUI compared with expectant management in couples with isolated cervical-factor subfertility.…”

mentioning

confidence: 99%

Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial

Steures

Steeg

Hompes

et al. 2007

Fertility and Sterility

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mentioning

confidence: 99%

Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial

Steures

Steeg

Hompes

et al. 2007

Fertility and Sterility

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“…Er werden vier studies, waarvan één Cochrane review en drie RCT's geïncludeerd voor het beantwoorden van deze uitgangsvraag. Helmerhorst (2005) beschrijft in een Cochrane review de effectiviteit van intrauteriene inseminatie (met semen van de partner) met en zonder ovariële stimulatie bij paren met een cervixfactor. Er werden zes studies geïncludeerd met in totaal 713 paren van wie er bij 384 sprake was van een cervixfactor.…”

Section: Intra-uteriene Inseminatie Bij Paren Met Een Afwijkende Postunclassified

Leerboek seksuologie

Hartog¹

2018

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Namens patiëntvereniging Freya Drs. S. Schols 1.6 Methodologische begeleiding van de werkgroep Drs. E.M.E. den Breejen adviseur Kennisinstituut van Medisch Specialisten te Utrecht (voorzitter) Dr. I. Mostovaya, adviseur Kennisinstituut van Medisch Specialisten te Utrecht Voor het ontwikkelen van de richtlijn is in 2013 een multidisciplinaire werkgroep ingesteld, bestaande uit vertegenwoordigers van de NVOG en patëntvereniging Freya. De werkgroepleden zijn door hun beroepsvereniging gemandateerd voor deelname. De werkgroep werkte gedurende twee jaar aan de totstandkoming van de richtlijn. De werkgroep is verantwoordelijk voor de integrale tekst van deze richtlijn. Werkgroep-lid Functie Nevenfuncties Persoonlijke financiële belangen Persoonlijke relaties Reputatiemanagement Extern gefinancierd onderzoek

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“…unexplained, and male and cervical factor subfertility, have been performed. [6][7][8][9]17 By means of these reviews we will identify studies for our IPD-MA. We will update the performed search strategies to include studies published up to date and we will check references and ask authors whether they are aware of unpublished studies in progress.…”

Section: Literature Search and Data Sharing Requestmentioning

confidence: 99%

“…4,5 The results of trials comparing IUI alone, IUI with COS, or EM with each other have been pooled in several metaanalyses. [6][7][8][9] A review on IUI for couples with unexplained subfertility showed a significant increase in pregnancy rates for treatment with both IUI and COS, separately. Data on multiple pregnancies and other adverse events after treatment with COS were insufficient to allow conclusions to be drawn.…”

Section: Introductionmentioning

confidence: 99%

The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation: a study protocol for the meta‐analysis of individual patient data

Boogaard¹,

Hompes²,

Barnhart³

et al. 2012

BJOG

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Please cite this paper as: Boogaard N van den, Hompes P, Barnhart K, Bhattacharya S, Custers I, Coutifaris C, Goverde A, Guzick D, Litvak P, Steures P, Veen F van der, Bossuyt P, Mol B. The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation: a study protocol for the meta‐analysis of individual patient data. BJOG 2012;119:953–957. Objective The current evidence concerning the best treatment option for couples with unexplained and male subfertility is inconclusive. Most studies that have evaluated the effectiveness of treatment options, such as expectant management (EM), intrauterine insemination (IUI), with or without controlled ovarian stimulation (COS), and in vitro fertilisation (IVF), have not taken the couples’ prognosis into account. It is very likely that the individual prognosis of the couple influences the effect of treatment. Individual patient data analyses allow us to take these prognostic factors into account, and to evaluate their effect on treatment outcome. This study aims to use anonymised data from relevant published trials to perform an individual patient data meta‐analysis, evaluating the effect of couples’ prognosis on the effectiveness of EM, IUI, with or without COS, and IVF. Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker‐by‐treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832). Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.

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Intra-uterine insemination versus timed intercourse for cervical hostility in subfertile couples

Cited by 8 publications

References 9 publications

Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial

Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial

Leerboek seksuologie

The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation: a study protocol for the meta‐analysis of individual patient data

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