Intra-vaginal gemcitabine-hybrid nanoparticles for effective cervical cancer treatment

Elhabak, Mona; Ibrahim, Samar; Ibrahim, Reem R.

doi:10.1016/j.onano.2022.100090

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…According to Wang et al [72], conjugate liposomes containing ER-over articulating breast cancer cells directly bound and took up doxorubicin. [71]. This led to innovative anticancer action with little macrophage and phagocytosis.…”

Section: Targeted Liposomes In Cancer Therapy-ligand-based Targetingmentioning

confidence: 99%

Section: Stomach Cancermentioning

confidence: 99%

“…In terms of prevalence and incidence, stomach cancer ranks fifth among all cancers and is the fourth greatest cause of death for both men and women [71]. While the incidence and death rates of stomach cancer in both men and women are substantially lower in India than in Eastern Asia and Eastern Europe [71], they are extremely high in the north-eastern regions of India, particularly in Mizoram ( [33]). Stomach cancer is the most prevalent cancer in Aizawl, Mizoram, according to the National Cancer Registry Programme's data, with 44.2 cases per 100,000 males and 21.7 cases per 100,000 women ( [33]).…”

Section: Stomach Cancermentioning

confidence: 99%

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Recent Therapy to Treat Various Types of Cancer: An Overview

Kumar,

Pal Singh

et al. 2024

JBPR

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Cancer is a fatal condition brought on by unchecked cellular growth. One of the gravest dangers to people worldwide is this. Both the incidence and mortality of cancer are rising. With their great benefits, particularly in the treatment of cancer, nanoparticles have revolutionized the globe. Conventional chemotherapy used to be the main treatment option for patients. Chemotherapeutics, however, also have several pharmacological drawbacks, including drug resistance, drug-drug interactions, water solubility, and stability. Reciprocally, dose-limiting toxicity is important, with non-specific toxicity to healthy cells, appetite loss, hair loss, peripheral neuropathy, vomiting, fatigued muscles, and diarrheal being the usual side effects. Drug delivery systems employ nanocarriers such as gold nanoparticles, high-density lipoprotein nanostructures, polymer nanoparticles, dendrimers, quantum dots, and nanodiamonds. Keywords: Nanotechnology, Cancer, Drug delivery

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Section: Targeted Liposomes In Cancer Therapy-ligand-based Targetingmentioning

confidence: 99%

Section: Stomach Cancermentioning

confidence: 99%

Section: Stomach Cancermentioning

confidence: 99%

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Recent Therapy to Treat Various Types of Cancer: An Overview

Kumar,

Pal Singh

et al. 2024

JBPR

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“…Sialic acid-conjugated chitosan NPs were proposed as a targeted medium for GEM delivery to non-small cell lung cancer [ 68 ]. On the other hand, intra-vaginal hybrid nanoparticles dedicated to cervical cancer were composed of a lecithin lipid core, mucoadhesive CS shell, and a penetration modifier [ 69 ]. In contrast to GEM, cytarabine is mainly used in hematological malignancies.…”

Section: Cs Np Platforms For a Specific Drug Deliverymentioning

confidence: 99%

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Kurczewska

2023

Pharmaceutics

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Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery systems of different active agents. Recently, much attention has been paid to nanodelivery systems as carriers to enable better bioavailability, and thus higher efficiency of the loaded drug. The present review is focused on the progress in chitosan-based nanoparticles for the targeted delivery of antitumor drugs. The paper discusses literature reports from the last three years in which chitosan nanoparticles were applied as carriers for active substances used in antitumor therapy and potential new drugs with anticancer properties. Special attention was paid to the different treatments applied to increase the therapeutic effectiveness and minimize the side effects of a specific active substance.

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Advance in Nanomedicine for Improving Mucosal Penetration and Effective Therapy of Cervical Cancer

Yang

Feng

et al. 2023

Small

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Insufficient intratumor drug distribution and serious adverse effects are often associated with systemic chemotherapy for cervical cancer. Considering the location of cervical cancer, access to the cervix through the vagina may provide an alternative administration route for high drug amounts at the tumor site, minimal systemic exposure as well as convenience of non‐invasive self‐medication. Enormous progress has been made in nanomedicine to improve mucosal penetration and enhance the effectiveness of therapy for cervical cancer. This review article first introduce the physiological state of cervicovaginal cavity and the characteristics of intravaginal environment in cervical cancers. Based on introduction to the physiological state of cervicovaginal cavity and the characteristics of intravaginal environment in cervical cancers, both “first mucus‐adhering then mucosal penetration” and “first mucus‐penetrating then mucosal penetration” strategies are discussed with respect to mechanism, application condition, and examples. Finally, existing challenges and future directions are envisioned in the rational design, facile synthesis, and comprehensive utilization of nanomedicine for local therapy of cervical cancer. This review is expected to provide useful reference information for future research on nanomedicine for intravaginally administered formulations for topical treatment of cervical cancer.

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Intra-vaginal gemcitabine-hybrid nanoparticles for effective cervical cancer treatment

Cited by 7 publications

References 55 publications

Recent Therapy to Treat Various Types of Cancer: An Overview

Recent Therapy to Treat Various Types of Cancer: An Overview

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Advance in Nanomedicine for Improving Mucosal Penetration and Effective Therapy of Cervical Cancer

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