Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold

Tateshima, Satoshi; Murayama, Yuichi; Villablanca, J. Pablo; Morino, Taku; Takahashi, Hiroto; Yamauchi, Terry; Tanishita, Kazuo; Viñuela, Fernando

doi:10.3171/jns.2001.95.6.1020

Cited by 86 publications

(73 citation statements)

References 37 publications

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“…In a recent study focusing on bleb formation in an effort to gain insight into the mechanisms underlying aneurysm rupture, the highest shear stress values were at or adjacent to the bleb formation. 38 Tsukahara et al 41 reported a global rupture rate of 3.42% per year and a rupture rate of 28.3% per year in aneurysms that contained bleb formation at the beginning of the observation period and observed that the likelihood of unruptured aneurysms to rupture was not exceedingly low, even when the aneurysms were smaller than 10 mm in diameter. Any change in the main sac structure introduces the possibility of significant influences of the perianeurysmal environment or other unknown factors.…”

Section: Projection Of Aneurysm and Bleb Formationmentioning

confidence: 99%

“…Second, alcohol consumption and smoking history were not quantitatively evaluated. Third, although intraaneurysm hemodynamics characteristics are also believed to be an important factor for aneurysm growth and rupture, 5,35,38 direct flow dynamics were not investigated. Fourth, the observed differences may reflect racial differences in the patient population because recent genetic analyses indicated that Japanese and/or Finnish patients are at a higher risk of rupture.…”

Section: Limitationsmentioning

confidence: 99%

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Morphological and clinical risk factors for posterior communicating artery aneurysm rupture

Matsukawa¹,

Fujii²,

Akaike

et al. 2014

JNS

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Object Recent studies have shown that posterior circulation aneurysms, specifically posterior communicating artery (PCoA) aneurysms, are more likely to rupture than other aneurysms. To date, few studies have investigated the factors contributing to PCoA aneurysm rupture. The authors aimed to identify morphological and clinical characteristics predisposing to PCoA aneurysm rupture. Methods The authors retrospectively reviewed 134 consecutive patients with PCoA aneurysms managed at their facility between July 2003 and December 2012. The authors divided patients into groups of those with aneurysmal rupture (n = 39) and without aneurysmal rupture (n = 95) and compared morphological and clinical characteristics. Morphological characteristics were mainly evaluated by 3D CT angiography and included diameter of arteries (anterior cerebral artery, middle cerebral artery, and internal carotid artery), size of the aneurysm, dome-to-neck ratio, neck direction of the aneurysmal dome around the PCoA (medial, lateral, superior, inferior, and posterior), aneurysm bleb formation, whether the PCoA was fetal type, and the existence of other intracranial unruptured aneurysm(s). Results Patients with ruptured PCoA aneurysms were significantly younger (a higher proportion were < 60 years of age) and a significantly higher proportion of patients with ruptured PCoA aneurysms showed a lateral direction of the aneurysmal dome around the PCoA, had bleb formation, and the aneurysm was > 7 mm in diameter and/or the dome-to-neck ratio was > 2.0. Multivariate logistic regression analysis showed age < 60 years (OR 4.3, p = 0.011), history of hypertension (OR 5.1, p = 0.008), lateral direction of the aneurysmal dome around the PCoA (OR 6.7, p = 0.0001), and bleb formation (OR 11, p < 0.0001) to be significantly associated with PCoA aneurysm rupture. Conclusions The present results demonstrated that lateral projection of a PCoA aneurysm may be related to rupture.

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Section: Projection Of Aneurysm and Bleb Formationmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Morphological and clinical risk factors for posterior communicating artery aneurysm rupture

Matsukawa¹,

Fujii²,

Akaike

et al. 2014

JNS

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“…8 Intra-aneurysmal hemodynamic characteristics are also believed to be an important factor for aneurysm growth and rupture. [9][10][11][12][13][14][15][16] With the help of advancements in medical imaging, realistic aneurysm geometry and vascular structure can be incorporated into simulations to perform patient-specific hemodynamic analysis. This type of image-based hemodynamic research has shown that ruptured aneurysms tend to have a more complicated flow pattern.…”

mentioning

confidence: 99%

Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations

Chien¹,

Castro²,

Tateshima³

et al. 2009

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Studies have shown that the occurrence of brain aneurysms and risk of rupture vary between locations. However, the reason that aneurysms at different branches of the cerebral arteries have different clinical presentations is not clear. Because research has indicated that aneurysm hemodynamics may be one of the important factors related to aneurysm growth and rupture, our aim was to analyze and compare the flow parameters in aneurysms at different locations.

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“…They recommended the use of high signalto-noise ratios, low echo times, and thick slices to minimize these velocity errors. Tateshima et al (17,18) were able to depict complex 3D intraaneurysmal velocity structures within a scaled up realistic basilar artery tip model with a basilar artery diameter of 10 mm with steady and pulsatile flow in a 1.5T scanner. They emphasized, however, that the equivalent detailed velocity information will be obtainable in vivo only with improvements in spatial resolution.…”

mentioning

confidence: 99%

Laser Doppler velocimetry (LDV) and 3D phase‐contrast magnetic resonance angiography (PC‐MRA) velocity measurements: Validation in an anatomically accurate cerebral artery aneurysm model with steady flow

Hollnagel

Summers

Kollias

et al. 2007

Magnetic Resonance Imaging

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Purpose:To verify the accuracy of velocity mapping with three-dimensional (3D) phase-contrast magnetic resonance angiography (PC-MRA) for steady flow in a realistic model of a cerebral artery aneurysm at a 3T scanner. Materials and Methods:Steady flow through an original geometry model of a cerebral aneurysm was mapped at characteristic positions by state-of-the-art laser Doppler velocimetry (LDV) as well as 3D PC-MRA at 3T. The spatial distributions and local values of two velocity components obtained with these two measurement methods were compared. Results:The 3D PC-MRA velocity field distribution and mean velocity values exhibited only minor differences to compare to the LDV measurements in straight artery regions for both main and secondary velocities. The differences increased in regions with disturbed flow and in cases where the measurement plane was not perpendicular to the main flow direction.Conclusion: 3D PC-MRA can provide reliable measurements of velocity components of steady flow in small arteries. The accuracy of such measurements depends on the artery size and the measurement plane positioning.

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Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold

Cited by 86 publications

References 37 publications

Morphological and clinical risk factors for posterior communicating artery aneurysm rupture

Morphological and clinical risk factors for posterior communicating artery aneurysm rupture

Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations

Laser Doppler velocimetry (LDV) and 3D phase‐contrast magnetic resonance angiography (PC‐MRA) velocity measurements: Validation in an anatomically accurate cerebral artery aneurysm model with steady flow

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