Intraaortic balloon pump support during coronary angioplasty. Initial experience

Osterne, Evandro César Vidal; Alexim, Gustavo A.; Motta, Vicente Paulo da; Lins, Rosaly M.M.; Carvalho, Eustáquio F.; Carneiro, Marcos; Morais, Elio Ribeiro de; Brick, Alexandre Visconti

doi:10.1590/s0066-782x1999000800007

Cited by 4 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After introduction to clinical practice in 1968, the intraaortic balloon pump was applied to patients undergoing elective high‐risk PCI [33, 34]. Using an 8 French (F) or 9F arterial sheath, vascular complications were seen in roughly 10% of patients, including limb ischemia, hematoma, overt bleeding, and blood transfusion [34, 35]. At the other extreme, large bore venous and arterial catheters utilized in percutaneous cardiopulmonary support (typically 18F) have been associated with far greater vascular complications, being experienced by as many as 40% of patients [36].…”

Section: Goals Of Percutaneous Cardiac Supportmentioning

confidence: 99%

Activation of target signal transducers utilizing chimeric receptors with signaling‐molecule binding motifs

Saka¹,

Kawahara²,

Ueda³

et al. 2012

Biotech & Bioengineering

View full text Add to dashboard Cite

Cellular fates such as proliferation, differentiation, and death are controlled by a variety of cytokine receptors, which are crucial in initiating downstream signaling cascades. To initiate signaling, the cytokine receptor cytoplasmic domain recruits specific signaling molecules with a range of tyrosine-containing motifs. Thus, we postulate that it is possible to regulate signal transduction artificially by locating the tyrosine motif of interest into the intracellular domain of specific receptors. Construction of such artificial receptors was based on an anti-fluorescein ScFv/c-Mpl chimera (S-Mpl). We selected several known tyrosine motifs from native cytokine receptors that strongly bind to their target molecule, and located them downstream of the Janus kinase (JAK) binding domain of S-Mpl, which would be necessary for phosphorylation of the receptor. Next, we used retroviral transduction to express chimeric receptors in a murine IL-3-dependent pro-B cell line, Ba/F3, which was stimulated with BSA-fluorescein. The results indicated that each chimeric receptor preferentially activated the corresponding signaling molecule. We also examined whether the position of the tyrosine motif in the receptor could influence the activation levels of the signal transducer, and found that the chimeric receptors could activate the corresponding signaling molecule even when the tyrosine motif was distant from the JAK binding domain.

show abstract

Section: Goals Of Percutaneous Cardiac Supportmentioning

confidence: 99%

Activation of target signal transducers utilizing chimeric receptors with signaling‐molecule binding motifs

Saka¹,

Kawahara²,

Ueda³

et al. 2012

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

The science behind percutaneous hemodynamic support: A review and comparison of support strategies

Burkhoff

Naidu

2012

Cathet Cardio Intervent

View full text Add to dashboard Cite

Patients in a variety of cardiovascular disease states may benefit from temporary percutaneous cardiac support, including those in acute decompensated heart failure, fulminant myocarditis, acute myocardial infarction with or without cardiogenic shock and those undergoing high-risk percutaneous coronary intervention. The ideal percutaneous cardiac support device is safe, easy to use and versatile enough to meet the needs of various clinical situations and patient cohorts. In addition, it should provide maximal hemodynamic support and protection against myocardial ischemia. With these goals in mind, the scientific principles that govern hemodynamic effectiveness and myocardial protection as they pertain to acute support devices are reviewed.

show abstract

Support Devices for High-Risk Percutaneous Coronary Interventions

Naidu¹,

Herrmann²

2012

Textbook of Interventional Cardiology

View full text Add to dashboard Cite

Intraaortic balloon pump support during coronary angioplasty. Initial experience

Abstract: Objective -To evaluate the use of the intraaortic balloon (IAoB) in association with coronary angioplasty in high-risk patients. Methods -

Cited by 4 publications

References 25 publications

Activation of target signal transducers utilizing chimeric receptors with signaling‐molecule binding motifs

Activation of target signal transducers utilizing chimeric receptors with signaling‐molecule binding motifs

The science behind percutaneous hemodynamic support: A review and comparison of support strategies

Support Devices for High-Risk Percutaneous Coronary Interventions

Contact Info

Product

Resources

About