Intraarterial abciximab for treatment of thromboembolism during coil embolization of intracranial aneurysms: outcome and fatal hemorrhagic complications

Park, Jae Hyo; Kim, Jeong Eun; Sheen, Seung Hun; Jung, Cheolkyu; Kwon, Bum Sun; Kwon, O-Ki; Oh, Chang Wan; Han, Moon Hee; Han, Dae Hee

doi:10.3171/jns/2008/108/3/0450

Cited by 50 publications

(61 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its plasma half-life is 2 hours, and following discontinuation of an infusion of tirofiban, 0.10 g/kg/min, ex vivo platelet aggregation returns to near baseline in 4 -8 hours in approximately 90% of patients. 14,19 Experience with tirofiban in the neuroendovascular setting has been limited. Chalouhi et al 20 assessed the safety and efficacy of tirofiban in stent-assisted coiling as a prophylactic treatment and as a rescue therapy for thromboembolic events.…”

Section: -12mentioning

confidence: 99%

“…However, several studies reported that abciximab and eptifibatide may induce fatal intracerebral hemorrhage. 7,[14][15][16] Moreover, abciximab binds irreversibly to the glycoprotein IIb/IIIa receptor causing platelet-function suppression for almost 48 hours after interruption of the infusion. 17 Tirofiban acts as a reversible antagonist of fibrinogen by binding to the glycoprotein IIb/IIIa receptor on platelets.…”

Section: -12mentioning

confidence: 99%

See 1 more Smart Citation

Safety and Efficacy of Intravenous Tirofiban as Antiplatelet Premedication for Stent-Assisted Coiling in Acutely Ruptured Intracranial Aneurysms

Kim¹,

Choi²,

Kang³

et al. 2015

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Stent-assisted coiling of intracranial aneurysms requires antiplatelet therapy, typically aspirin and clopidogrel to prevent thromboembolic complications. There is a substantial concern that tirofiban may increase the risk of hemorrhage when used as an antiplatelet premedication in ruptured intracranial aneurysms. Our aim was to evaluate the safety and efficacy of intravenous tirofiban administration, instead of oral dual antiplatelet agents, as an antiplatelet premedication for stent-assisted coiling in patients with acutely ruptured intracranial aneurysms.

show abstract

Section: -12mentioning

confidence: 99%

Section: -12mentioning

confidence: 99%

Safety and Efficacy of Intravenous Tirofiban as Antiplatelet Premedication for Stent-Assisted Coiling in Acutely Ruptured Intracranial Aneurysms

Kim¹,

Choi²,

Kang³

et al. 2015

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…However other researchers have identified that intra-arterial abciximab could induce fatal hemorrhage (11,16). In addition, operations such as decompressive craniectomy or external ventricular drainage are sometimes necessary after coil embolization, especially in cases of ruptured cerebral aneurysms.…”

Section: Resultsmentioning

confidence: 99%

Intra-arterial infusion of tirofiban and urokinase for thromboembolic complications during coil embolization of ruptured intracranial aneurysms

Feng¹,

Chen²,

Lv³

et al. 2014

Turkish Neurosurgery

View full text Add to dashboard Cite

AIm: To investigate the effectiveness and safety of intra-arterial tirofiban and urokinase for thromboembolic complications during detachable coil treatment of ruptured intracranial aneurysms. mATERIAl and mEThods: Fourteen patients who had a thromboembolic complication during detachable coil treatment of ruptured cerebral aneurysms from May 2011 to October 2013 were enrolled in this study. Within one hour of thrombus formation, patients underwent intra-arterial infusion of tirofiban plus urokinase with digital subtraction angiography monitoring. Blood flow was checked every 5 min with angiography until complete or partial recanalization of the occluded artery occurred. REsulTs:Of the 14 patients, 10 exhibited complete recanalization immediately after the thrombolytic treatment, and had no neurological dysfunction except one patient with mild hemiplegia. Two patients with partial recanalization exhibited mild neurological dysfunction and one died of cardiac infarction during the recovery period. Two patients had intracranial hemorrhage. In one of these, this was caused by rupture of the aneurysm and the patient died during the thrombolytic treatment. In the remaining patient, intracranial hemorrhage was caused by a puncture of the left posterior internal frontal artery caused by mechanical thrombolysis.CoNClusIoN: Intra-arterial administration of tirofiban plus urokinase is an effective and safe treatment for thromboembolism during detachable coil treatment of ruptured intracranial aneurysms.

show abstract

“…23 Three patients had small residual filling of the aneurysm neck (near-complete) at the end of the embolization procedure (patients 1, 3, and 4). Patient 1 required additional coil embolization of the residual aneurysm neck 2 days later.…”

Section: Immediate Angiographic Resultsmentioning

confidence: 99%

Short- and Intermediate-Term Angiographic and Clinical Outcomes of Patients with Various Grades of Coil Protrusions Following Embolization of Intracranial Aneurysms

Abdihalim¹,

Kim²,

Maud³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:An infrequent occurrence during endovascular treatment is protusion of detachable coils into the parent lumen with a subsequent thrombosis within in the parent vessel or embolic events. We report the short-and intermediate-term angiographic and clinical outcomes of patients who experience coil or loop protrusions and are managed with medical or additional endovascular treatments.

show abstract

Intraarterial abciximab for treatment of thromboembolism during coil embolization of intracranial aneurysms: outcome and fatal hemorrhagic complications

Cited by 50 publications

References 22 publications

Safety and Efficacy of Intravenous Tirofiban as Antiplatelet Premedication for Stent-Assisted Coiling in Acutely Ruptured Intracranial Aneurysms

Safety and Efficacy of Intravenous Tirofiban as Antiplatelet Premedication for Stent-Assisted Coiling in Acutely Ruptured Intracranial Aneurysms

Intra-arterial infusion of tirofiban and urokinase for thromboembolic complications during coil embolization of ruptured intracranial aneurysms

Short- and Intermediate-Term Angiographic and Clinical Outcomes of Patients with Various Grades of Coil Protrusions Following Embolization of Intracranial Aneurysms

Contact Info

Product

Resources

About