Intraarterial Association of CIS-Platinum and Bleomycin in Head and Neck Cancer

Galmarini, Felipe C.; Yoel, J; Nakasone, Juan; Molina, Carlos Maria Coni

doi:10.1016/s0385-8146(85)80065-1

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Patients with advanced head and neck cancer are most appropriate targets because their blood supply is readily accessible by current surgical techniques and tumor response is easily assessed (14). Briefly, by surgical procedure, a catheter is inserted and placed through the superficial temporal artery along the external carotid artery up to the tumor-supplying vessel (17). We emphasize the importance of the distance to which the catheter must be introduced in order to place its tip in front of the desired collateral vessel.…”

Section: Clinical Modelmentioning

confidence: 99%

Heterogeneous Distribution of Tumor Blood Supply Affects the Response to Chemotherapy in Patients with Head and Neck Cancer

Galmarini¹,

Galmarini²,

Sarchi³

et al. 2000

Microcirculation

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Heterogeneity in the distribution of tumor blood supply affects the response to chemotherapy by influencing the intratumoral delivery of therapeutic agents. After the administration of effective doses of anticancer drugs to a tumor, cells in profusely perfused areas receive enough to destroy them while cells in the poorly perfused areas are exposed to lower drug concentrations and, therefore, survive. This phenomenon could explain in part the difficulty in the treatment of human solid tumors.

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Section: Clinical Modelmentioning

confidence: 99%

Heterogeneous Distribution of Tumor Blood Supply Affects the Response to Chemotherapy in Patients with Head and Neck Cancer

Galmarini¹,

Galmarini²,

Sarchi³

et al. 2000

Microcirculation

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“…On the other hand, anemia and leukopenia were in some cases prolonged, requiring several transfusions and, in a few cases, postponing of surgical operation. The median time from start of intraarterial treatment and operation was 32 days (range [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Resultsmentioning

confidence: 99%

“…Consistent data also exist for the use of cisplatin and bleomycin as single intra-arterially administered and their combination has also been reported recently. 34 Based on these considerations, we started a prospective induction intra-arterial chemotherapy program employing the combination of these 2 drugs in previously untreated locally advanced head and neck squamous cell carcinomas, which forms the basis of this article.…”

mentioning

confidence: 99%

Induction intra‐arterial cisplatin and bleomycin in head and neck cancer

et al. 1991

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Fifty-two consecutive patients, affected by large T2 (greater than 3 cm), T3, T4, N0, or N1 previously untreated squamous cell carcinoma of the head and neck, entered this phase I-II study. Treatment consisted of a continuous 8-day infusion on the following daily schedule: cisplatin 25 mg and bleomycin 15 mg administered for 4 and 20 hours, respectively. Technical-related toxicities were 1 case each of coagulation and displacement of the catheter and 1 case of reversible monoparesis of the contralateral arm. Drug-related relevant toxicities accounted for 4 cass of grade 3 or 4 leukopenia and 2 cases of peripheral palsy of the 7th and 12th cranial nerve, respectively. Forty-five of 50 evaluable patients obtained an objective response. In particular, 13 patients obtained a complete response, 22 a partial response greater than or equal to 75%, and 10 a partial response greater than or equal to 50%. Furthermore, 5 of 31 patients showed a complete pathologic disappearance of the tumor, whereas in 12 of 31 only a microscopic residue was found.

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“…In fact, IA chemotherapy delivery has been used at academic institutions as early as 1985. 11 Robbins et al 12 presented results from a phase I study in which the maximum tolerated cisplatin dose was determined to be 150 mg/m 2 per week for 4 weeks. Robbins built on this and other studies to begin the RADPLAT treatment protocol.…”

Section: Discussionmentioning

confidence: 99%

“…Intra‐arterial chemotherapy is not a new concept. In fact, IA chemotherapy delivery has been used at academic institutions as early as 1985 11 . Robbins et al 12 presented results from a phase I study in which the maximum tolerated cisplatin dose was determined to be 150 mg/m 2 per week for 4 weeks.…”

Section: Discussionmentioning

confidence: 99%