Intraarterial Chemotherapy

Hepatic Artery Occlusion with Perfusion in the Treatment of Carcinoid Syndrome

“…Hematopoietic suppression did not occur in either patient, but the dosage of intra arterial 5-FU may require reduction in patients with advanced liver disease [20], Hepatic encephalopathy associated with therapy was not seen in either case. Intra-arterial perfusion may result in technical com plications such as catheter dislodgement, migration and vessel perforation [5,12,20], Balloon arterial occlusion should minimize these complications by stabilization of the catheter tip. The present tech nique requires bed rest when systemic heparinization is maintained but greater patient mobility may be achieved by using the brachial artery approach [5,12,15].…”

“…No indication of bacterial endocarditis occurred in the second case and it is reasonable to attribute the valvular heart disease to the carcinoid syndrome [1]. Hematopoietic suppression did not occur in either patient, but the dosage of intra arterial 5-FU may require reduction in patients with advanced liver disease [20], Hepatic encephalopathy associated with therapy was not seen in either case. Intra-arterial perfusion may result in technical com plications such as catheter dislodgement, migration and vessel perforation [5,12,20], Balloon arterial occlusion should minimize these complications by stabilization of the catheter tip.…”

“…Reports of accidental or inten tional artery ligation at surgery have confirmed this approach and temporary ligation has been proposed Intra-arterial chemotherapy perfusion of hepatic tumors without arterial occlusion has been used in a variety of tumors including the carcinoid syndrome [5,[12][13][14][15], Simultaneous arterial occlusion and regional perfusion of tumors was first reported by Creech et al [16,17] two decades ago and most experience was achieved with pelvic and extremity tumors [18,19], The technique, often requiring major surgery and general anesthesia, was cumbersome and frequently resulted in hematopoietic suppression. Surgical mor bidity and local toxicity lessened enthusiasm for this technique in the treatment of intrathoracic and ab dominal tumors [20], Our first case represented an elderly patient with inoperable disease in whom the carcinoid syndrome could not be controlled by medical means in com bination with systemic chemotherapy. It is interesting to note that following initiation of systemic chemo therapy and adjuvant agents the 5-HIAA fell to normal levels yet he remained debilitated by his illness.…”

Regional chemotherapy through a saphenous vein graft for the treatment of head and neck cancers

“…It is recommended that the position of the catheter tip be checked as frequently as twice a week. 27 The catheter has to be chemotherapy. t Largest dimension in centimeters.…”

Diesel cars in the United States

“…In South Dakota, for example, the Cenex Co-op has many diesel fuel stations to serve farmers, which accounts for the high proportion of diesel fuel In 1976 and, the average price at truck stops was roughly 0.5¢ to 2¢/gal, less than at service stations. The average price at independent stations was roughly 2¢ to 4¢/gal less than at major oil company stations (Lundberg letter, 12 August, 1977, plus Lundberg Surveys, July-December 1977. Naturally, variations among stations are considerably greater than these variations in the average diesel fuel price among the categories of stations--as much as 25¢/gal difference between the lowest and highest prices in July 1977.…”