Intraarterial protein delivery via intimally-adherent bilayer hydrogels

An, Yanjun; Hubbell, Jeffrey A.

doi:10.1016/s0168-3659(99)00143-1

Cited by 86 publications

(47 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hydrogels are a class of water-insoluble polymers with good swelling properties in the presence of aqueous solutions or physiological fluids, thus able to retain large fractions of water within their structure. 1,2 This class of materials appears particularly appealing for many biological and biomedical applications, [2][3][4][5][6][7] because their high water content and biocompatibility make them similar to naturally soft tissue more than any other types of biomaterials. In the last few years, the possibility to vary the chemical composition and the molecular structure of polymers allowed us to extend the use of hydrogels to tissue engineering, controlled drug delivery and bio-nanotechnology.…”

Section: Introductionmentioning

confidence: 99%

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

et al. 2015

View full text Add to dashboard Cite

The molecular mechanism responsible for the thermosensitive behaviour exhibited by pH-responsive cyclodextrin-based hydrogels is explored here with the twofold aim of clarifying some basic aspects of H-bond interactions in hydrogel phases and contributing to a future engineering of cyclodextrin hydrogels for targeted delivery and release of bioactive agents. The degree of H-bond association of water molecules entrapped in the gel network and the extent of intermolecular interactions involving the hydrophobic/ hydrophilic moieties of the polymer matrix are probed by UV Raman and IR experiments, in order to address the question of how these different and complementary aspects combine to determine the pH-dependent thermal activation exhibited by these hydrogels. Complementary vibrational spectroscopies are conveniently employed in this study with the aim of safely disentangling the spectral response arising from the two main components of the hydrogel systems, i.e. the polymer matrix and water solvent. The experimental evidence suggests that the dominant effects in the mechanism of solvation of cyclodextrin-based hydrogels are due to the changes occurring, upon increasing of temperature, in the hydrophobicity character of specific chemical moieties of the polymer, as triggered by pH variations. The achievements of this work corroborate the potentiality of the UV Raman scattering technique, in combination with more conventional IR experiments, to provide a ''molecular view'' of complex macroscopic phenomena exhibited in hydrogel phases.

show abstract

Section: Introductionmentioning

confidence: 99%

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Due to their elastic strength, 22 swelling ability, 14 and bio-compatibility 23 poly(ethylene-glycol) hydrogel systems are promising for cartilage, 9 tissue replacements, 24 arterial coating, 11 and bio-sensors. 25 Four different poly(ethylene-glycol)dimethacrylate (PEGDMA) systems were prepared with the following combination of absorption (μ a ) and scattering (μ s ) coefficients: (1) low μ a and low μ s , (2) high μ a and low μ s , (3) low μ a and high μ s , and (4) high μ a and high μ s .…”

Section: Hydrogel Materials and Illuminationmentioning

confidence: 99%

“…Originally used in the field of coatings, printing, paints, adhesives, optical fibers, etch resist, or printed circuits, [3][4][5][6] it quickly found its way into the biomedical sector where photopolymerizable materials are used for dental implants, 7 cell encapsulation, 8 tissue-replacements, 9,10 drug delivery, 11 implant coatings, bio-glues, 12 and microfluidics. 13 However, when materials are introduced and cross-linked in the body by means of photopolymerization, illumination becomes challenging, since surgical procedures tend to be minimally invasive: 14 large-polymer volumes have to be illuminated with small light-emitting surfaces, for example through the tip of an optical fiber.…”

Section: Introductionmentioning

confidence: 99%

Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimentalin vitrovalidation

et al. 2014

View full text Add to dashboard Cite

Abstract. Photopolymerization is commonly used in a broad range of bioapplications, such as drug delivery, tissue engineering, and surgical implants, where liquid materials are injected and then hardened by means of illumination to create a solid polymer network. However, photopolymerization using a probe, e.g., needle guiding both the liquid and the curing illumination, has not been thoroughly investigated. We present a Monte Carlo model that takes into account the dynamic absorption and scattering parameters as well as solid-liquid boundaries of the photopolymer to yield the shape and volume of minimally invasively injected, photopolymerized hydrogels. In the first part of the article, our model is validated using a set of well-known poly(ethylene glycol) dimethacrylate hydrogels showing an excellent agreement between simulated and experimental volume-growthrates. In the second part, in situ experimental results and simulations for photopolymerization in tissue cavities are presented. It was found that a cavity with a volume of 152 mm 3 can be photopolymerized from the output of a 0.28-mm 2 fiber by adding scattering lipid particles while only a volume of 38 mm 3 (25%) was achieved without particles. The proposed model provides a simple and robust method to solve complex photopolymerization problems, where the dimension of the light source is much smaller than the volume of the photopolymerizable hydrogel. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

“…Initially, photopolymerization was used for coatings, printing, paints, adhesives, optical fibers, etch resist, or printed circuits. [3][4][5][6] It has found its way into the biomedical sector, where photopolymerizable materials are used for dental implants, 7 cell encapsulation, 8,9 tissue-replacements, 10,11 drug delivery, 12 implant coatings, bio-glues, 13 and microfluidics.…”

Section: Introductionmentioning

confidence: 99%

Miniature probe for the delivery and monitoring of a photopolymerizable material

et al. 2015

View full text Add to dashboard Cite

Abstract. Photopolymerization is a common method to cure materials initially in a liquid state, such as dental implants or bone or tissue fillers. Recent advances in the development of biocompatible gel-and cement-systems open up an avenue for in situ photopolymerization. For minimally invasive surgery, such procedures require miniaturized surgical endoscopic probes to activate and control photopolymerization in situ. We present a miniaturized light probe in which a photoactive material can be (1) mixed, pressurized, and injected, (2) photopolymerized/photoactivated, and (3) monitored during the chemical reaction. The device is used to implant and cure poly(ethylene glycol) dimethacrylate-hydrogel-precursor in situ with ultraviolet A (UVA) light (365 nm) while the polymerization reaction is monitored in real time by collecting the fluorescence and Raman signals generated by the 532-nm excitation light source. Hydrogels could be delivered, photopolymerized, and monitored by the probe up to a curing depth of 4 cm. The size of the photopolymerized samples could be correlated to the fluorescent signal collected by the probe, and the reproducibility of the procedure could be demonstrated. The position of the probe tip inside a bovine caudal intervertebral disc could be estimated in vitro based on the collected fluorescence and Raman signal. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Intraarterial protein delivery via intimally-adherent bilayer hydrogels

Cited by 86 publications

References 25 publications

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimentalin vitrovalidation

Miniature probe for the delivery and monitoring of a photopolymerizable material

Contact Info

Product

Resources

About