Intraarticular morphine after arthroscopic ACL reconstruction: A double-blind placebo-controlled study of 40 patients

Brandsson, Sveinbjörn; Karlsson, Jón; Morberg, Per; Rydgren, B.; Eriksson, Bengt I.; Hedner, Thomas

doi:10.1080/000164700317411889

Cited by 47 publications

(47 citation statements)

References 28 publications

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“…1 Such imbalance may be of importance in several RCTs. 35,36,38,39,44,45,[48][49][50][51][52][53][54][55][56][57][58][59][60][61] All these trials, placebo controlled or not, had a group size below 20, which gives an OPVS item number 2 score of 0/3.…”

Section: Most Positive Trials Are Of Low Research Quality And/or Havementioning

confidence: 99%

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Rosseland

2005

Regional Anesthesia and Pain Medicine

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There are few well-controlled RCTs on IA morphine, and the negative trials of higher quality counter the evidence from the numerous positive ones of lower quality. The quality of most published trials is poor, and performing meta-analysis on these data is not meaningful. Properly controlled trials, in which early postoperative pain intensity is documented, suggest that there is no added analgesic effect of IA morphine compared with saline alone.

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Section: Most Positive Trials Are Of Low Research Quality And/or Havementioning

confidence: 99%

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Rosseland

2005

Regional Anesthesia and Pain Medicine

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“…Further studies have demonstrated anti-inflammatory effects Lindegaard et al, 2010b) and a lack of local tissue toxicity (Todhunter et al, 1996;Tulamo et al, 1996;Jaureguito et al, 2002). After intra-articular injec-PERIPHERAL PAIN INHIBITION tion, morphine was detectable in synovial fluid for up to 24 h but did not reach clinically significant concentrations in the systemic circulation (Lawrence et al, 1992;Tulamo et al, 1996;Richardson et al, 1997;Brandsson et al, 2000;Lindegaard et al, 2010a).…”

Section: A Treatment Of Pain and Inflammationmentioning

confidence: 99%

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

2011

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“…However, opioids are characterized by significant side effects, such as respiratory depression, constipation, and tolerance, that often prohibit their long-term use (5-7). Alternatively, intrathecal or intraarticular injections have been shown to be effective routes of opioid administration for the management of joint pain (8,9).…”

mentioning

confidence: 99%

Amelioration of pain and histopathologic joint abnormalities in the Col1‐IL‐1β^XAT mouse model of arthritis by intraarticular induction of μ‐opioid receptor into the temporomandibular joint

Kyrkanides¹,

Fiorentino²,

Miller³

et al. 2007

Arthritis & Rheumatism

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Objective. To evaluate opioid receptor function as a basis for novel antinociceptive therapy in arthritis.Methods. We induced human -opioid receptor (HuMOR) expression in arthritic joints of mice, using the feline immunodeficiency virus (FIV) vector, which is capable of stably transducing dividing, growth-arrested, and terminally differentiated cells . Male and female Col1-IL-1␤ XAT -transgenic mice developed on a C57BL/6J background and wild-type littermates were studied.Results Conclusion. Our results indicate that prophylactic therapy with MOR overexpression in joints can successfully prevent the development of pain, dysfunction, and histopathologic abnormalities in the joints in arthritis. These findings may provide a basis for the future development of spatiotemporally controlled antinociceptive and antiinflammatory therapy for arthritis.Tissue injury caused by trauma, infection, and/or arthritis can produce inflammation, spontaneous pain, and hyperalgesia (1,2). In fact, according to US Public Health Service (PHS) estimates, Ͼ50 million Americans experience pain every year, with 45% seeking medical care at some point in their lives and 40% of pain patients never receiving adequate relief. Lipton et al (3) reported that 22% of the US population had experienced Ն1 episode of orofacial pain in the previous 6 months.

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Intraarticular morphine after arthroscopic ACL reconstruction: A double-blind placebo-controlled study of 40 patients

Cited by 47 publications

References 28 publications

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Amelioration of pain and histopathologic joint abnormalities in the Col1‐IL‐1β^XAT mouse model of arthritis by intraarticular induction of μ‐opioid receptor into the temporomandibular joint

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Intraarticular morphine after arthroscopic ACL reconstruction: A double-blind placebo-controlled study of 40 patients

Cited by 47 publications

References 28 publications

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Amelioration of pain and histopathologic joint abnormalities in the Col1‐IL‐1βXAT mouse model of arthritis by intraarticular induction of μ‐opioid receptor into the temporomandibular joint

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Amelioration of pain and histopathologic joint abnormalities in the Col1‐IL‐1β^XAT mouse model of arthritis by intraarticular induction of μ‐opioid receptor into the temporomandibular joint