Intraarticular soluble interleukin‐17 receptor levels are increased in patients with rheumatoid arthritis and correlate with local mediators of inflammation: Comment on the article by Pickens et al

Moret, Frederique M; Badot, Valérie; Lauwerys, Bernard; Roon, Joël A G van

doi:10.1002/art.33373

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…We did not find a correlation between intraarticular TSLP levels and local concentrations of several proinflammatory cytokines (including TNFα, IL‐6, and IL‐8). The TSLP concentrations, however, did correlate with intraarticular concentrations of soluble IL‐7Rα, an antagonist of IL‐7, which was recently shown to be increased in RA patients and to correlate with fibroblast activation, which is regulated by multiple inflammatory cytokines ().…”

Section: Discussionmentioning

confidence: 93%

Thymic Stromal Lymphopoietin, a Novel Proinflammatory Mediator in Rheumatoid Arthritis That Potently Activates CD1c+ Myeloid Dendritic Cells to Attract and Stimulate T Cells

Moret

Hack

Wurff-Jacobs

et al. 2014

Arthritis & Rheumatology

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Objective. To determine the levels of thymic stromal lymphopoietin (TSLP) and the numbers of TSLP receptor (TSLPR)-expressing CD1c؉ (blood dendritic cell antigen 1-positive) myeloid dendritic cells (MDCs) in the joints as compared with the peripheral blood (PB) of patients with rheumatoid arthritis (RA), as well as to determine the capacity of TSLP to induce MDCdependent T cell activation.Methods. TSLP levels were measured in synovial fluid (SF) samples from patients with RA and those with osteoarthritis (OA). MDC numbers in PB and SF samples from RA patients and TSLPR expression on these cells were assessed by fluorescence-activated cell sorter analysis. PB and SF MDCs from RA patients were stimulated with TSLP, and cytokine production was measured by multiplex immunoassay. TSLP-primed MDCs were cocultured with autologous CD4؉ T cells in the absence of additional stimuli, and subsequently, cell proliferation and cytokine production were measured.Results. TSLP levels were significantly increased in SF samples from RA versus OA patients. The numbers of TSLPR-expressing MDCs in the SF of RA patients were significantly increased as compared to those in the PB, and SF MDCs displayed increased levels of TSLPR. TSLP selectively stimulated the production of thymus and activation-regulated chemokine and macrophage inflammatory protein 1␣ by CD1c؉ MDCs. TSLP-primed MDCs from PB and SF potently stimulated the proliferation of autologous CD4؉ T cells as compared to unstimulated MDCs. Enhanced proliferation was associated with increased production of interferon-␥, interleukin-17 (IL-17), and IL-4.Conclusion. These data support an inflammatory mechanism by which increased intraarticular TSLP in RA potently activates TSLPR-expressing CD1c؉ MDCs in the joints to secrete chemokines, causing chemotaxis and subsequent activation of CD4؉ T cells. In addition to the demonstrated inflammatory potential of TSLP in experimental arthritis, this suggests that TSLP and TSLPR-expressing MDCs could both play a pivotal role in the immunopathology of RA.

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Section: Discussionmentioning

confidence: 93%

Thymic Stromal Lymphopoietin, a Novel Proinflammatory Mediator in Rheumatoid Arthritis That Potently Activates CD1c+ Myeloid Dendritic Cells to Attract and Stimulate T Cells

Moret

Hack

Wurff-Jacobs

et al. 2014

Arthritis & Rheumatology

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“…Signi cantly, lupus nephritis and interstitial lung disease are common comorbidities in patients with SLE, and the higher the cumulative disease activity, the higher the risk of comorbidities [32][33][34] . In our study, we found that the serum TSLP level of the SLE-ILD group was signi cantly higher than that of the SLE group without comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Thymic Stromal Lymphopoietin Is Associated With Disease Activity in Systemic Lupus Erythematosus

Lai

Yang

Ding

et al. 2021

Preprint

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Objective To investigate the association between Thymic stromal lymphopoietin (TSLP) and disease activity in patients with Systemic Lupus Erythematosus (SLE).Methods In this study, concentrations of serum TSLP in 65 SLE patients, 50 sex and age-matched control subjects were determined by enzyme-linked immunosorbent assay (ELISA).Results Serum TSLP concentrations in SLE patients were dramatically higher than healthy controls. The levels of serum TSLP displayed a significant increase as compared with healthy controls. More importantly, TSLP levels were significantly correlated with SLE disease activity features such as ESR, CRP, Anti-dsDNA Ab, and SLEDAI-2K,. The predictive value of TSLP on high disease activity was superior to those of CRP, ESR, and Anti-dsDNA Ab. A note worthy correlation in our study was observed between the serum TSLP levels and laboratory parameters, particularly serum lipids. Furthermore, serum TSLP levels could be significantly down-regulated after effective integrative treatment.Conclusion TSLP may serve as a novel sensitive biomarker to assist disease activity assessment and monitor therapeutic effects in active SLE patients.

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“…Nonetheless, strongly increased levels of T cell–activating cytokines such as IL‐7 and IL‐15 were detected in the SF of patients with RA . With respect to IL‐7, strongly increased levels of soluble IL‐7 receptor α (IL‐7Rα), which was recently shown to potentiate IL‐7, were also detected in the SF of RA patients . Although the levels of soluble IL‐15Rα in the SF remain to be determined, it was shown that soluble IL‐15Rα largely improves the biologic activity of IL‐15 .…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Abatacept in Reducing Synovial T Cell Activation by CD1c Myeloid Dendritic Cells Is Overruled by the Stimulatory Effects of T Cell–Activating Cytokines

Moret

Bijlsma

Lafeber

et al. 2015

Arthritis & Rheumatology

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Intraarticular soluble interleukin‐17 receptor levels are increased in patients with rheumatoid arthritis and correlate with local mediators of inflammation: Comment on the article by Pickens et al

Cited by 6 publications

References 9 publications

Thymic Stromal Lymphopoietin, a Novel Proinflammatory Mediator in Rheumatoid Arthritis That Potently Activates CD1c+ Myeloid Dendritic Cells to Attract and Stimulate T Cells

Thymic Stromal Lymphopoietin, a Novel Proinflammatory Mediator in Rheumatoid Arthritis That Potently Activates CD1c+ Myeloid Dendritic Cells to Attract and Stimulate T Cells

Thymic Stromal Lymphopoietin Is Associated With Disease Activity in Systemic Lupus Erythematosus

The Efficacy of Abatacept in Reducing Synovial T Cell Activation by CD1c Myeloid Dendritic Cells Is Overruled by the Stimulatory Effects of T Cell–Activating Cytokines

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