“…In a systematic review of intra-articular injections during arthroscopic knee surgery, intra-articular injections resulted in a weighted mean difference in visual analog scale (VAS) pain scores of 11 mm (95% CI, 7 to 17 mm; p < 0.05) as well as a 10% to 40% reduction in supplemental analgesic requests 5 . There is also evidence that, when administered alone, single-shot intra-articular local anesthetic injections are significantly more effective for managing procedure-related pain than saline solution injections or no injections during anterior cruciate ligament (ACL) reconstruction 28 , total knee arthroplasty 8 , and arthroscopic knee [9][10][11][12][13][14][15][16] , hip 17 , wrist 18 , and ankle 19 surgery. Our subjects who received intra-articular bupivacaine required a significantly lower opioid dose postoperatively (from arrival in the post-anesthesia care unit to discharge) than did patients in the control group.…”