2021
DOI: 10.1186/s13104-021-05704-7
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Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

Abstract: Objective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previous… Show more

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