Intracameral moxifloxacin after cataract surgery: a prospective study

Abstract

The results suggest moxifloxacin is a safe option for intracameral use after cataract surgery.

The impact of antibiotic prophylaxis with intracameral cefuroxime on postoperative infectious endophthalmitis rates in a high-volume cataract surgery center

“…We did not consider the intracameral use of moxifloxacin or vancomycin due to potential toxicity and local regulations. The available formulations of moxifloxacin in Brazil contain preservatives and adjuvants that are toxic to ocular structures 20 ; even the most used eye drops in our country (Vigamox®, Alcon), market as not having preservatives, has a warning that the solution should not be injected under the conjunctiva, nor introduced directly into the anterior chamber of the eye 20 , 21 . Other studies performed in other locations have, however, shown good results on its use, safety, and efficacy 16 , 22 .…”

An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection

“…Moxifloxacin hydrochloride (MOX) is often the drug of choice, as it has been shown to have higher intraocular bioavailability compared to other fluoroquinolones 3,20 . However, overall limitations in drug absorption with eye drops mean that prophylactic antibiotic drops still must be used three times or more per day 21,22 …”

“… 3 , 20 However, overall limitations in drug absorption with eye drops mean that prophylactic antibiotic drops still must be used three times or more per day. 21 , 22…”

“…3,20 However, overall limitations in drug absorption with eye drops mean that prophylactic antibiotic drops still must be used three times or more per day. 21,22 Various strategies have been employed for increasing intraocular drug penetration with topical dosing. 23 One common approach is the addition of viscosity enhancing materials or the use of creams and ointments, which have issues with messiness and blurring vision.…”

Why do scientific advances take so long to be incorporated into clinical practice? The case of intracameral injection of antibiotics to prevent acute endophthalmitis after cataract surgery

“…In 2007, a major clinical study by the European Society of Cataract and Refractive Surgeons (ESCRS) (3) demonstrated the benefits of intracameral cefuroxime. Recently, three Brazilian studies have demonstrated the safety and efficacy of intracameral moxifloxacin (4)(5)(6) . Nevertheless, the adoption of such scientifically-proven strategies in clinical practice is hindered by other factors.…”